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| 1 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 2 | Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles显示文摘磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究,我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比, HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时, T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次, chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。 | Ruijun Xing Ashwinkumar A. Bhirde Shouju Wang Xiaolian Sun Gang Liu Yanglong Hou Xiaoyuan Chen | 2013 | Nano Research2013，6，1： | 11 |
| 3 | Study on Closed-set Speaker Identification Based on Biomimetic Pattern Recognition显示文摘 | WU Lili WANG Shoujue | 2009 | Chinese Journal of Electronics2009，18，2： | 4 |
| 4 | Blind Image Restoration Based on the Theory of High-Dimensional Space Geometry显示文摘 | WANG Shoujue CAO Yu HUANG Yi | 2007 | Chinese Journal of Electronics2007，16，2： | 2 |
| 5 | A Neural Network Constructing Method Based on Many Kinds of Neurons Model显示文摘 | WANG Xianbao CAO Wenming FENG Hao WANG Shoujue | 2005 | 通讯和计算机(中英文版)2005，2，1： | 2 |
| 6 | Mathematical Symbols and Computing Methods in High Dimensional Biomimetic Informatics and Their Applications显示文摘 | WANG Shoujue LIU Xingxing | 2008 | Chinese Journal of Electronics2008，17，1： | 1 |
| 7 | A New Filtering Algorithm Based on Extremum and Median Value显示文摘 | Xing Cangiu Wang Shoujue Deng Haojiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 8 | A Cancer Recognition Method Based on DNA Microarray显示文摘 | SU Qian AN Dong ZHAI Yafeng WANG KU WANG Shoujue | 2009 | Chinese Journal of Electronics2009，18，3： | 1 |
| 9 | A new development on ANN in China -biomimetic pattern recognition and multi weight vector neurons显示文摘 | WANG Shoujue | 2003 | RSFDGrC2003，，： | 1 |
| 10 | Application of geometrical learning for similarity index about clustering DNA microarray data显示文摘 | CAO Wenming WANG Shoujue | 2005 | LECTURE NOTES IN ARTIFICIAL INTELLIGENCE2005，，3642： | 1 |
| 11 | A New Filtering Algorithm Based on Extremum and Median Value显示文摘 | Xing Cangju Wang Shoujue Dang Haojiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 12 | A Point-to-Point Tracking Algorithm Based on the Theory of Floating Pixels显示文摘Based on the theory of floating pixels, a point-to-point tracking algorithm based on local features is presented. A novel texture-based feature set is proposed in a form of high dimensional vector which describes each single point. Point-to-point matching is applied in a way of vector operation at multiple scales. Each match is verified by variance analysis, and unreliable matches are corrected with candidates available. Experimental results demonstrate that this algorithm maintains strong robustness when target-appearance is varying and environment is complex. | WANG Shoujue JIANG Yuwen TAN Leyi | 2016 | Chinese Journal of Electronics2016，25，1： | 1 |
| 13 | Facile Synthesis of Yolk–Shell Structured Inorganic–Organic Hybrid Spheres with Ordered Radial Mesochannels显示文摘 | Zhaogang Teng Shouju Wang Xiaodan Su Guotao Chen Ying Liu Zhimin Luo Wei Luo Yuxia Tang Huangxian Ju Dongyuan Zhao Guangming Lu | 2014 | Adv Mater2014，，22： | 1 |
| 14 | Geometrioal learning,descriptive geometry,and biomimetic pattern recognition显示文摘 | Wang Shoujue Lai Jiangliang | 2005 | Nenrocomputing2005，67，14： | 1 |
| 15 | A new filtering algorithm based on extremum and median value显示文摘 | Xing Zangju Wang Shoujue Deng Hanjiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 16 | A study on artificial neurons with multi-threshold transfer functions显示文摘 | Wang Shoujue | 1995 | Chinese journal of Electruics1995，4，2： | 1 |
| 17 | An adaptive confroller for a class of nonlinear system using direction basis fanction显示文摘 | Cao Wenning Fenghao Wang Shoujue | 2002 | ChineseJournal of Electronics2002，11，3： | 1 |
| 18 | Modeling and optimization of semiconductor manufacturing process with neural networks显示文摘 | Wang Shoujue | 2000 | Chinese Journal of Electronics2000，9，1： | 1 |
| 19 | Multidimensional spacegeometric analysis and its theory of neural network显示文摘 | WANG Bonan | 2002 | Journal of Electronic2002，30，5： | 1 |
| 20 | A general purpose neuro processor with digital-analog processing显示文摘 | Wang Shoujue Wang Liyan Wei Yun Lu Huaxiang | 1994 | Chinese Journal of Electronics1994，3，4： | 1 |
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