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| 1 | Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles显示文摘磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究,我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比, HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时, T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次, chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。 | Ruijun Xing Ashwinkumar A. Bhirde Shouju Wang Xiaolian Sun Gang Liu Yanglong Hou Xiaoyuan Chen | 2013 | Nano Research2013，6，1： | 11 |
| 2 | Identification of Odor Volatile Compounds and Deodorization ofPaphia undulata Enzymatic Hydrolysate显示文摘Unfavorable fishy odour is an inevitable problem in aquatic products. In the present study, headspace solid-phase microextraction gas chromatography mass spectrometry(HS-SPME-GC-MS) analysis of volatiles from untreated samples and three deodorized samples(under the optimal conditions) of Paphia undulata enzymatic hydrolysate revealed that the compounds contributing to the distinctive odor were 1-octen-3-ol, n-hexanal, n-heptanal, 2,4-heptadienal, and 2,4-decadienal, whereas n-pentanal, n-octanal, n-octanol, benzaldehyde, 2-ethylfuran and 2-pentylfuran were the main contributors to the aromatic flavor. The deodorizing effects of activated carbon(AC) adsorption, yeast extract(YE) masking and tea polyphenol(TP) treatment on a P. undulata enzymatic hydrolysate were investigated using orthogonal experiments with sensory evaluation as the index. The following optimized deodorization conditions were obtained: AC adsorption(35 mg mL^(-1), 80℃, 40 min), YE masking(7 mg mL^(-1), 45℃, 30 min) and TP treatment(0.4 mg mL^(-1), 40℃, 50 min). AC adsorption effectively removed off-flavor volatile aldehydes and ketones. YE masking modified the odor profile by increasing the relative contents of aromatic compounds and decreasing the relative contents of aldehydes and ketones. The TP treatment was not effective in reducing the odor score, but it significantly reduced the relative content of aldehydes while increasing that of alkanes. It is also notable that TP effectively suppressed trimethylamine(TMA) formation in a P. undulate hydrolysate solution for a period of 72 h. | CHEN Deke CHEN Xin CHEN Hua CAI Bingna WAN Peng ZHU Xiaolian SUN Han SUN Huili PAN Jianyu | 2016 | Journal of Ocean University of China2016，15，6： | 10 |
| 3 | Color-tunable Gd-Zn-Cu-ln-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging显示文摘 | Weisheng Guo Weitao Yang Yu Wang Xiaolian Sun Zhongyun Liu Bingbo Zhang Jin Chang Xiaoyuan Chen | 2014 | Nano Research2014，7，11： | 8 |
| 4 | A DFT study of Ti_(3)C_(2)O_(2)MXenes quantum dots supported on single layer graphene:Electronic structure an hydrogen evolution performance显示文摘Heterojunction structure has been extensively employed for the design of novel catalysts.In the present study,density functional theory was utilized to investigate the electronic structure and hydrogen evolution performance of Ti_(3)C_(2)O_(2)MXene quantum dots/graphene(QDs/G)heterostructure.Results show that a slight distortion can be observed in graphene after hybriding with QDs,due to which the electronic structure of QDs have been changed.Associated with such QDs-graphene interaction,the catalytic activity of Ti_(3)C_(2)O_(2)QDs has been optimized,leading to excellent HER catalytic performance. | Qingquan Kong Xuguang An Lin Huang Xiaolian Wang Wei Feng Siyao Qiu Qingyuan Wang Chenghua Sun | 2021 | Frontiers of physics2021，16，5： | 2 |
| 5 | Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin B1显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian Jun Zhou F.S. Chu | 2004 | International Journal of Food Microbiology2004，，2： | 2 |
| 6 | Evaluation of spatial epitope computational tools based on experimentally-confirmed dataset for protein antigens显示文摘Antibody molecules interact with antigen proteins through the epitope area,where the epitope residues are found to be discontinuous or spatial or conformational rather than linear on the protein surface.There are various computational algorithms to predict the spatial epitopes,and each of them have an outstanding performance based on their individual testing dataset.In this work,an independent dataset was created through collection of the epitope residual sites which have been confirmed by experiments. Based on this dataset,6 popular web-servers developed for B-cell structural epitope prediction,including SEPPA,CEP,DiscoTope,ElliPro,PEPOP and BEpro,were evaluated and compared according to sensitivity,the positive predictive value,the successful pick-up rate and the area under the curve of the receiver operator characteristic(AUC).The results showed that the general performance of spatial epitope prediction tools did obtain substantial advancement,and SEPPA gave the best performance among the 6 tools.However,the current prediction accuracy was still far from satisfaction.Moreover,our comparison elucidated that the performance of the web-servers was significantly affected by their training datasets and the algorithms adopted.In this sense,the results of our research may improve the design of B-cell epitope prediction tools and provide additional clues when the users utilize these tools in their related research. | XU XiaoLian SUN Jing LIU Qi WANG XiaoJing XU TianLei ZHU RuiXin WU Di CAO ZhiWei | 2010 | Chinese Science Bulletin2010，55，20： | 2 |
| 7 | Development of an immunochromatographic assay for detection of aflatoxin B1 in foods显示文摘 | SUN Xiulan ZHAO Xiaolian TANG Jian | 2006 | Food Control2006，17，： | 1 |
| 8 | Preparation ofgold-labeled antibody probe and its use in immunochromatographyassay for detection of aflatoxin Bj显示文摘 | SUN Xiulian ZHAO Xiaolian TANG Jian | 2005 | International Journal of FoodMicrobiology2005，99，2： | 1 |
| 9 | Development of an immunochromatographic assay for detection of aflatoxin B1 in foods显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian | 2006 | Food Control2006，，17： | 1 |
| 10 | Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin BI 显示文摘 | SUN Xiulan ZHAO Xiaolian TANG Jian | 2005 | Int J Food Micro2005，99，2： | 1 |
| 11 | Electrochemiluminescence of CdSe quantum dots for immunosensing of human prealbumin 显示文摘 | JIE Guifen HUANG Haiping SUN Xiaolian | 2008 | Biosens Bioelectron2008，23，12： | 1 |
| 12 | Development of an immunochromatographic assay for detection of aflatoxin B1 in foods显示文摘 | Zhao Xiaolian Tang Jian | 2006 | Food Control2006，17，： | 1 |
| 13 | Development of an immunochromatographic assay for detection of aflatoxin B in foods显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian | 2006 | Food Control2006，17，4： | 1 |
| 14 | Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin B1显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian | 2005 | International Journal of Food Microbidogy2005，99，： | 1 |
| 15 | Development of an immuno- chromatographic assay for detection of aflatoxin B1 in foods显示文摘 | Sun Xiulan Zhao Xiaolian | 2006 | Food Control2006，17，4： | 1 |
| 16 | Development of an immunochromatographic assay for detection of aflatoxin BI in foods显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian | 2006 | Food Control2006，，17： | 1 |
| 17 | Porous hollow palladium nanoplafform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy显示文摘 | Menglin Song Nian Liu Le He Gang Liu Daishun Ling Xinhui Su Xiaolian Sun | 2018 | Nano Research2018，11，5： | 1 |
| 18 | Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin BI显示文摘 | Sun Xiulan Zhao Xiaolian Tang Jian | 2005 | International Journal of Food Microbiology2005，99，2： | 1 |
| 19 | Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor显示文摘Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications.Weprepared 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I labeling.The 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in vivo.Due to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h post-injection.Meanwhile,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 h.These radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for tumor.Together with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in clinic.Whafs more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application. | Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie Xiaolian Sun | 2019 | Nano Research2019，12，12： | 1 |
| 20 | Development of an immunochromatographic assay for detection of aflatoxin B1 in foods显示文摘 | Sun Xiulan Zhao Xiaolian | 2006 | Food Control2006，17，： | 1 |
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