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| 1 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 2 | Development of High Sensitivity Eight-Element Multiplexed Fiber Laser Acoustic Pressure Hydrophone Array and Interrogation System显示文摘纤维激光水中听音器由于唯一的优点和宽广申请前景得到了普遍担心。在这篇论文,研究八元素的多路的纤维激光结果声学的压力数组和讯问系统被介绍,包含的低噪音的分布式的反馈纤维激光(DFB-FL ) 制造,包装的敏感改进,和 interferometric 表明解调。系统的频率反应范围是 10Hz-10kHz,声学的压力敏感到达的激光频率 115 dB re Hz/Pa,和声学的压力是的相等的噪音不到 60Pa/Hz 1/2 。系统的动态范围比 120 dB 大。 | Ming LI Zhihui SUN Xiaolei ZHANG Shujuan LI Zhiqiang SONG Meng WANG Jian GUO Jiasheng NI Chang WANG Gangding PENG Xiangang XU | 2017 | Photonic Sensors2017，7，3： | 4 |
| 3 | Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling显示文摘Activation of vitamin D receptor(VDR)in cancer-associated fibroblasts(CAFs)has been implicated in hesitating tumor progression and chemoresistance of several human malignancies.Yet,the role of VDR in CAF-induced chemotherapy resistance of gastric cancer(GC)cells remains elusive.In this study we first conducted immunohistochemistry analysis on tissue microarrays including 88 pairs of GC and normal mucosa samples,and provided clinical evidence that VDR was mainly expressed in gastric mucous cells but almost invisible in CAFs,and VDR expression was negatively correlated with malignant clinical phenotype and advanced stages,low VDR expression confers to poor overall survival rate of patients with GC.In a co-culture system of primary CAFs and cancer cells,we showed that treatment of HGC-27 and AGS GC cells with VDR ligand calcipotriol(Cal,500 nM)significantly inhibited CAF-induced oxaliplatin resistance.By using RNA-sequencing and Human Cytokine Antibody Array,we demonstrated that IL-8 secretion from CAFs induced oxaliplatin resistance via activating the PI3K/AKT pathway in GC,whereas Cal treatment greatly attenuated the tumor-supportive effect of CAF-derived IL-8 on GC cells.Taken together,this study verifies the specific localization of VDR in GC tissues and demonstrates that activation of VDR abrogates CAF-derived IL-8-mediated oxaliplatin resistance in GC via blocking PI3K/Akt signaling,suggesting vitamin D supplementation as a potential strategy of enhancing the anti-tumor effect of chemotherapy in GC. | Zhen-xiong Zhao Yan-qiu Zhang Hui Sun Zi-qi Chen Jin-jia Chang Xin Wang Xu Wang Cong Tan Shujuan Ni Wei-wei Weng Meng Zhang Lei Wang Dan Huang Yun Feng Wei-qi Shen Mi-die Xu | 2023 | Acta Pharmacologica Sinica2023，44，1： | 2 |
| 4 | Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 HTTPS://DOI.ORG/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction. | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu Qifeng Wang Shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong Hua Zhaohui Huang | 2021 | Protein & Cell2021，12，8： | 1 |
| 5 | The Future of Hydrogen Infrastructure for Fuel cell Vehicles in China and a case of Application in Beijing 显示文摘 | Wen Feng Shujuan Wang Weiduo Ni | 2003 | International Journal of Hydrogen Energy2003，，： | 1 |
| 6 | Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer 显示文摘 | Zhaohui Huang Dan Huang Shujuan Ni | 2010 | International Journal of Cancer2010，127，1： | 1 |
| 7 | Phytoestrogens induce differential estrogen receptor β-mediated responses in transfected MG-63 cells显示文摘 | Xiaolu Tang Xiaoyan Zhu Shujuan Liu Richard C. Nicholson Xin Ni | 2008 | Endocrine (-)2008，，1： | 1 |
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