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| 1 | The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage显示文摘在应力之上,肿瘤 suppressor p53 的水平显著地被提高,是众所周知的。然而尽管有广泛的研究,包含的内在的机制重要为导致压力的 p53 规定内部播放器仍然不充分被理解。我们人的 lincRNA-RoR (RoR ) 是 p53 的一个强壮的否定管理者的现在的证据。不同于通过 ubiquitin-proteasome 小径引起 p53 降级的 MDM2, RoR 通过和异构的原子 ribonucleoprotein 的直接相互作用压制 p53 翻译我(hnRNP 我) 。重要地,带 hnRNP 的一个 28 底 RoR 序列我有约束力的主题为 p53 压抑必要、足够。我们进一步证明 RoR 禁止调停 p53 的房间周期拘捕和 apoptosis。最后,我们表明 p53 transcriptionally 导致 RoR 表示的一个 RoR-p53 自动调整的反馈环。一起,这些结果建议 RoR-hnRNP I-p53 轴可以组成一个另外的监视网络让房间更好对各种各样的压力作出回应。 | Ali Zhang Nanjiang Zhou Jianguo Huang Qian Liu Koji Fukuda Ding Ma Zhaohui Lu Cunxue Bai Kounosuke Watabe Yin-Yuan Mo | 2013 | Cell Research2013，23，3： | 47 |
| 2 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 3 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 4 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 5 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 6 | Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG显示文摘Two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible NGN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical NGG PAM sites tested, whereas it showed limited activity at non-canonical NGH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at NGG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-NG variants, Cas9-NGv1 and Cas9-NG, for targeting NGN PAMs. Both Cas9-NG variants showed higher editing efficiency at most non-canonical NG PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-NG variants showed significant reduced activity at the canonical NGG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-NG had much higher editing efficiency than Cas9-NGv1 and xCas9 at NG PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-NG nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical NGG PAMs and Cas9-NG as a preferred variant for targeting relaxed PAMs for plant genome editing. | Zhaohui Zhong Simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang | 2019 | Molecular Plant2019，12，7： | 13 |
| 7 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 8 | Preparation and characterization of capric-palmitic-stearic acid ternary eutectic mixture/expanded vermiculite composites as form-stabilized thermal energy storage materials显示文摘In this study, a composite of form-stable phase change materials(FSPCMs) were prepared by the incorporation of a eutectic mixture of capric–palmitic–stearic acid(CA–PA–SA) into expanded vermiculite(EV)via vacuum impregnation. In the composites, CA–PA–SA was utilized as a thermal energy storage material,and EV served as the supporting material. X-ray diffraction and Fourier transform infrared spectroscopy results demonstrated that CA–PA–SA and EV in the composites only undergo physical combination, not a chemical reaction. Scanning electron microscopy images indicated that CA–PA–SA is sufficiently absorbed in the expanded vermiculite porous network. According to differential scanning calorimetry results, the70 wt% CA–PA–SA/EV sample melts at 19.3℃ with a latent heat of 117.6 J/g and solidifies at 17.1℃ with a latent heat of 118.3 J/g. Thermal cycling measurements indicated that FSPCMs exhibit adequate stability even after being subjected to 200 melting–freezing cycles. Furthermore, the thermal conductivity of the composites increased by approximately 49.58% with the addition of 5 wt% of Cu powder. Hence,CA–PA–SA/EV FSPCMs are effective latent heat thermal energy storage building materials. | Weiyi Zhang Xiaoguang Zhang Zhaohui Huang Zhaoyu Yin Ruilong Wen Yaoting Huang Xiaowen Wu Xin Min | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 9 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 10 | Analysis of Corneal Spherical Aberration in Patients before and after Phacoemulsification显示文摘Purpose:To investigate the distribution and changes in corneal four-order spherical aberration Z40 in patients with age-related cataract before and after phacoemulsification,and to direct the application of aspherical intraocular lens (IOL)in PHACO combined with IOL implantation.Methods:A total of 155 eyes in 93 patients with age-related cataract were included.All patients received a comprehensive ophthalmologic examination.Corneal Z40 at a pupil diameter of 6 mm was measured by using a Scheimpflug photography system (Pentacam) preoperatively and 3 months postoperatively.Results:The mean corneal Z40 before and after the PHACO at a diameter of 6 mm was(0.294 ±0.138)μm and(0.271 ± 0.130)μm,respectively,with statistical significance(P<0.05, t =4.384).There was no significant difference between male (n=45, 76 eyes) and female patients (n=48,79 eyes) regard- ing corneal Z40 (t=-0.418,P=0.676).The corneal Z40 for patients (35 eyes) aged from 50 to 59 years was (0.238±0.104) μm preoperatively;(0.308 ±0.104)μm for 60 to 69 years; (0.332±0.151)μm for 70 to 79 years; and (0.307±0.164) μm for 80 to 89 years.A significant difference in Z40 was observed among different age groups.A linear positive correlation was noted between corneal Z40 and ages (r=0.203,P<0.003). Conclusion:The corneal Z40 varied significantly among cataract patients. Patients' corneal Z40 , which should be considered when choosing aspherical IOL, increases slightly with age.Thus,customized aspheric IOLs are needed. | Liexi Jia Yifei Huang Zhaohui Li | 2012 | Eye Science2012，27，4： | 6 |
| 11 | Flow Instability of a Centrifugal Pump Determined Using the Energy Gradient Method显示文摘The stability of the centrifugal pump has not been well revealed because of the complexity of internal flow. To analyze the flow characteristics of a centrifugal pump operating at low capacity, methods of numerical simulation and experimental research were adopted in this paper. Characteristics of the inner flow were obtained. Standard k–ε turbulence models were used to calculate the inner flow of the pump under off-design conditions. The distribution of the energy gradient function K was obtained by three-dimensional numerical simulation at different flow rates. The relative velocity component was acquired from the absolute velocity obtained in particle image velocimetry. By comparing with experimental results, it was found that flow instability occurs at the position of maximum K. The flow stability reduces with an increasing flow rate. The research results provide a theoretical basis for the optimization design of a centrifugal pump. | Li Yi Dong Wenlong He Zhaohui Huang Yuanmin Jiang Xiaojun | 2015 | Journal of Thermal Science2015，24，1： | 5 |
| 12 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 13 | Combined amendment reduces soil Cd availability and rice Cd accumulation in three consecutive rice planting seasons显示文摘The scientific application of stabilized materials has been considered an effective method for the in situ remediation of Cd-contaminated soil.This study aimed to investigate the persistence of the effect of a combined amendment of limestone and sepiolite(LS)on soil Cd availability and accumulation in rice grown in a mildly Cd-contaminated paddy field(0.45 mg/kg of Cd)over three consecutive rice seasons.1125–4500 kg/ha of LS was applied to the soil before the first rice planting season and 562.5–2250 kg/ha of LS was supplemented before the third rice planting season.The application of LS(1125–4500 kg/ha)increased the soil p H by 0.44–1.09,0.18–0.53,and 0.42–0.68 in the first,second,and third season,respectively,and decreased the soil acid-extractable Cd content by 18.2–36.4%,17.7–33.5%,and9.6–17.6%.LS application significantly decreased the Cd contents in the rice tissues.The application of 4500 kg/ha of LS decreased the Cd content in brown rice to below the National Food Limit Standard of 0.2 mg/kg(GB 2762-2017)in the three consecutive rice seasons.However,the effect of LS on the soil-rice system was significantly weakened in the third season.The supplementary application of 562.5–2250 kg/ha of LS further decreased the Cd content in brown rice by 26.1–56.5%and decreased the health risk index by 23.7–43.8%.Therefore,it was recommended to apply 4500 kg/ha of LS in the first season and to supplement2250 kg/ha of LS in the third season to effectively guarantee the clean production of rice in three consecutive rice seasons. | Wenjun Yang Shilong Wang Hang Zhou Min Zeng Jingyi Zhang Fang Huang Shiping Shan Zhaohui Guo Hongwei Yi Zhiguang Sun Jiaofeng Gu Bohan Liao | 2022 | Journal of Environmental Sciences2022，34，1： | 4 |
| 14 | Morphology-controllable solvothermal synthesis of nanoscale LiFePO_4 in a binary solvent显示文摘LiFePO4(LFP) nanobars,microplates and nanorods have been selectively synthesized via a solvothermal method in a water-ethylene glycol(EG) binary solvent with H3PO4,LiOH·H2O,and FeSO4·7H2O as starting materials.The morphology and size of the as-obtained LFP products can be deliberately controlled by varying the volume ratio of EG to water.The formation mechanism and electrochemical properties of different LFP morphologies have been investigated.With carbon coating,the Li-ion diffusion coefficients of LFP nanorods,nanobars and micro-plates are 2.58×10-9,2.91×10-10,and 7.22×10-10 cm2 s-1,respectively.For the carbon-coated nanorods,excellent rate capability and cyclability were attained.At 5 C,the capacity was 141 mAh g-1 for the first cycle and maintained 120 mAh g-1 after 100 cycles;at 10 C,the capacity was still as high as 132 mAh g-1. | WU Miao WANG ZhaoHui YUAN LiXia ZHANG WuXing HU XianLuo HUANG YunHui | 2012 | Chinese Science Bulletin2012，57，32： | 4 |
| 15 | Porous Si/C composite as anode materials for high-performance rechargeable lithium-ion battery显示文摘A novel porous silicon was synthesized through a magnesiothermic reduction method of molecular sieve for the first time, Si/C composite was synthesized by using pitch as carbon source. The porous Si/C composite shows a high initial specific capacity of 2018.5 mAh/g with current density of 0.1 A/g. When the current density increases to 2 A/g, it still exhibits high average specific capacity of 640.3 mAh/g. The porous structure can remit the Si particle pulverization during the lithiation/delithiation process. This article can provide a reference for the research of the porous Si anode for the high performance rechargeable lithium-ion battery. | Bingbing Deng Lian Shen Yangai Liu Tao Yang Manshu Zhang Renjie Liu Zhaohui Huang Minghao Fang Xiaowen Wu | 2017 | Chinese Chemical Letters2017，28，12： | 4 |
| 16 | On-chip chalcogenide microresonators with low-threshold parametric oscillation显示文摘Chalcogenide glass (ChG) is an attractive material for highly efficient nonlinear photonics,which can cover an ultrabroadband wavelength window from the near-visible to the footprint infrared region. However,it remains a challenge to implement highly-efficient and low-threshold optical parametric processes in chip-scale ChG devices due to thermal and light-induced instabilities as well as a high-loss factor in ChG films. Here,we develop a systematic fabrication process for high-performance photonic-chip-integrated ChG devices,by which planarintegrated ChG microresonators with an intrinsic quality (Q) factor above 1 million are demonstrated. In particular,an in situ light-induced annealing method is introduced to overcome the longstanding instability underlying ChG film. In high-Q ChG microresonators,optical parametric oscillations with threshold power as low as 5.4 mW are demonstrated for the first time,to our best knowledge. Our results would contribute to efforts of making efficient and low-threshold optical microcombs not only in the near-infrared as presented but more promisingly in the midinfrared range. | BIN ZHANG PINGYANG ZENG ZELIN YANG DI XIA JIAXIN ZHAO YAODONG SUN YUFEI HUANG JINGCUI SONG JINGSHUN PAN HUANJIE CHENG DUKYONG CHOI ZHAOHUI LI | 2021 | Photonics Research2021，9，7： | 4 |
| 17 | PRESENT STATUS OF EXPERIMENTAL STUDY ON HEAVY METAL POLLUTANT ADSORPTION-DESORPTION BY SEDIMENT IN CHINA显示文摘PRESENTSTATUSOFEXPERIMENTALSTUDYONHEAVYMETALPOLLUTANTADSORPTION-DESORPTIONBYSEDIMENTINCHINAHUANGSuiliangandWANZhaohui(Postdoc... | HUANG Suiliang and WAN Zhaohui( Sediment Research Laboratory,Department of Hydraulic Engineering,Tsinghua University,Beijing, 100084, China)( China Institute of Water Conservancy and Hydroelectric Power Research,Beijing, P.O. Box 366, 100044, China) | 1995 | International Journal of Sediment Research1995，10，3： | 3 |
| 18 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 19 | Vibration power flow in infinite stiffened-plate with force excitation applied on plate显示文摘The formula of the vibration response and power flow in beam-stiffened plate with force excitation applied on.the plate, have been obtained by using the Steepest Descent Integral method. The characteristics of the power flow have been studied through computer simulation.It is shown that the stiffener acts as an extra lineal excitation applied on the plate and changes the characteristics of the power flow of the infinite plate greatly The greater the stiffness and the smaller the distance between the exciting point and the stiffener is, the greater the induence is. Lastly, experiments have been carried out by using the dualaccelerometer measurement technique that based on cross spectrum, and the test data agree well with the theoretical | WANG Minqing (Xi’an Jiaotong University Xi’an 710049) SHENG Meiping SUN Jincai SUN Zhaohui (Institute of Acoustical Engineering, Northwestern Polytechnical University Xi’an 710072) HUANG Xieqing (Xi,an Jiaotong University Xi’an 710049) | 1998 | Chinese Journal of Acoustics1998，17，2： | 3 |
| 20 | LncRNA HOTAIR promotes endometrial fibrosis by activating TGF-β1/Smad pathway显示文摘Homeobox transcript antisense RNA(HOTAIR)is a long non-coding RNA associated with a number of fibrosis-related diseases.The aim of this study was to investigate the specific role of HOTAIR in the development of endometrial fibrosis and to identify the molecular mechanisms underlying this process.Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)was used to determine the expression levels of HOTAIR in samples of intrauterine adhesion(lUA)tissue and in endometrial stromal cells(ESCs)that had been treated with transforming growth factor beta 1(TGF-β1).Additionally,we transfected ESCs with either overexpression plasmid(pcDNA-HOTAIR)or silencing construct(si-HOTAIR)and then treated these cells with TGF-β1.We then performed RTqPCR and western blot analysis,along with cell proliferation and apoptosis assays,to investigate the effects of HOTAIR on the transdifferentiation of ESCs into myofibroblasts.The results showed that the expression levels of HOTAIR were significantly elevated in IUA tissue and in ESCs that had been treated with TGF-β1.The overexpression of HOTAIR had a pro-fibrotic effect on ESCs,while the silencing of HOTAIR exerted an anti-fibrotic effect.Most importantiy,the protein expression levels of p-Smad2 and p-Smad3 were significantly upregulated in TGF-β1.treated ESCs transfected with pcDNA-HOTAIR and were downregulated after transfection with si-HOTAIR constructs.These data indicate that HOTAIR promotes endometrial fibrosis by activating the TGF-β1/Smad signaling pathway,suggesting that the inhibition of HOTAIR may represent a promising therapeutic option for suppressing endometrial fibrosis. | Jianhong Wu Lingge Jin Yudi Zhang Aihong Duan Juhong Liu Ziwen Jiang Liang Huang Jing Chen Zhaohui Liu Dan Lu Yinmei Dai | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 3 |
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