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| 1 | Aptamer-wrapped gold nanoparticles for the colorimetric detection of omethoate显示文摘Organophosphorous pesticide(OP) contamination has serious adverse effects on human health and the environment. Due to the toxicity of OPs and the threat presented by their accidental or intentional release in populated areas, the determination and monitoring of these OPs in food products and environment is of great importance. OPs are present in very small quantities and therefore, methods for their detection need to be highly sensitive and selective. Here, we aimed to develop a simple and selective aptamer-based colorimetric assay for the detection of omethoate, which is one of the commonly used OPs. The principle of the assay is that single-stranded DNA(ss DNA)-wrapped gold nanoparticles(Au NPs) are resistant to salt-induced aggregation. By employing an 'artificial antibody' organophosphorous pesticide-binding aptamer(OBA) as the recognition element, aptamer-wrapped Au NPs(Au-apta) show high selectivity towards omethoate, resulting in the disconnection of aptamers from Au NPs and the aggregation of Au NPs. As there is a significant color change from the interparticle plasmon coupling during the aggregation of Au NPs, the established assay showed good linearity between 0.1 and 10 μmol/L, with a low detection limit of 0.1 μmol/L. Other OPs such as profenofos, phorate, and isocarbophos would not interfere with the detection of omethoate despite having similar structures. Thus, the colorimetric method shows potential for use in the detection of omethoate in real soil samples. | Pengjuan Wang Ying Wan Aldalbahi Ali Shengyuan Deng Yan Su Chunhai Fan Shulin Yang | 2016 | Science China Chemistry2016，59，2： | 6 |
| 2 | SeDeM Expert System: A review and new perspectives显示文摘The SeDeM Expert System was first known as a galenic pre-formulation system, which was based on the experimental research and quantitative determination of powdered substances. And the mathematical formula provided by the SeDeM Expert System has plays an important role in the study of powder properties. The system can be used not only to evaluate the powder direct compression (DC) of excipients and active pharmaceutical ingredients (API’s), but also to predict the possible formulations, so it can reduce unnecessary research and trials, and shorten the time of development. In this paper, the research development and application of SeDeM Expert System in DC was summarized, and the results showed that with a few exceptions, the system was skilled in predicting acceptable tablet formulations. Finally, the new application prospect of the system is presented, including the application of the Internet traffic and content management (iTCM) database and the new co-processed excipients. | Mingxian Gu Tianbing Guan Shulin Wan Han Zhang Xuelian Li Songtao Kong Jianbing Ren Huimin Sun Chuanyun Dai | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，1： | 1 |
| 3 | Direct condensation of sulfonamide and formamide: NaI-catalyzed synthesis of N-sulfonyl formamidine using TBHP as oxidant显示文摘 | CHEN Shulin XU Yuan WAN Xiaobing | 2011 | Organic Letters2011，13，： | 1 |
| 4 | Microstructure and mechanical properties of rheo-diecast hypereutectic Al–Si alloy with 2%Fe assisted with ultrasonic vibration process显示文摘 | Chong Lin Shusen Wu Shulin Lü Ping An Li Wan | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 5 | Effects of ultrasonic vibration and manganese on microstructure and mechanical properties of hypereutectic Al–Si alloys with 2%Fe显示文摘 | Chong Lin Shusen Wu Shulin Lü Ping An Li Wan | 2013 | Intermetallics2013，，： | 1 |
| 6 | Ultrasensitive Electrochemical Aptasensor Based on Surface-Initiated Enzymatic Polymerization显示文摘结合了快、量的反应的能力,电气化学的 aptasensors (EA ) 在癌症 biomarker 的早诊断的申请有大潜力。以便在 complicate 决定稀罕 biomarkers 临床的样品,科学家们向改进 EA 的敏感和选择正在作不停的努力。此处,“三明治”结构电气化学的 aptasensor (海) 为癌症 biomarker 的分析被开发 carcino 胚胎的抗原(CEA ) 。二 DNA aptamers 被采用其一是在 3 ′-terminal 的 thiolated 并且作为一根俘获探针使不能调动到金电极上,当另一个是被服务时,表明探查。二 aptamers 能“夹”目标,信号探查然后受到催化的终端 deoxynucleotidyl transferase (TdT ) biotin 的加入把 dNTPs 标记进它的 3 ′-terminal。因此,同样产生的长 DNA oligo 尾巴允许众多的卵白素的特定的绑定修改山葵 peroxidase (Av-HRP ) ,导致提高的 peroxidase 催化电气化学的信号。当表面开始了酶的聚合(SIEP ) ,这信号扩大策略被称为。这 SIEP 放大了海有显示突出的扩大效率的 10 pg·mL −1, 的察觉限制。 | Pengjuan Wang Ying Wan Yan Su Shengyuan Deng Shulin Yang | 2016 | Chinese Journal of Chemistry2016，34，3： | 0 |
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