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| 1 | Type 1 CD8^+ T Cells are Superior to Type 2 CD8^+ T Cells in Tumor Immunotherapy due to Their Efficient Cytotoxicity,Prolonged Survival and Type 1 Immune Modulation显示文摘CD8+ cytotoxic T(Tc) cells play a crucial role in host immune responses to cancer,and in this context,adoptive CD8+ Tc cell therapy has been studied in numerous animal tumor models. Its antitumor efficacy is,to a large extent,determined by the ability of Tc cells to survive and infiltrate tumors. In clinical trials,such in vitro-activated T cells often die within hours to days,and this greatly limits their therapeutic efficacy. CD8+ Tc cells fall into two subpopulations based upon their differential cytokine secretion. In this study,we in vitro generated that ovalbumin(OVA) -pulsed dendritic cell(DCOVA) -activated CD8+ type 1 Tc(Tc1) cells secreting IFN-γ,and CD8+ type 2 Tc(Tc2) cells secreting IL-4,IL-5 and IL-10,which were derived from OVA-specific T cell receptor(TCR) transgenic OT I mice. We then systemically investigated the in vitro and in vivo effector function and survival of Tc1 and Tc2 cells,and then assessed their survival kinetics after adoptively transferred into C57BL/6 mice,respectively. We demonstrated that,when compared to CD8+ Tc2,Tc1 cells were significantly more effective in perforin-mediated cytotoxicity to tumor cells,had a significantly higher capacity for in vivo survival after the adoptive T cell transfer,and had a significantly stronger therapeutic effect on eradication of well-established tumors expressing OVA in animal models. In addition,CD8+ Tc1 and Tc2 cells skewed the phenotype of CD4+ T cells toward Th1 and Th2 type,respectively. Therefore,the information regarding the differential effector function,survival and immune modulation of CD8+ Tc1 and Tc2 cells may provide useful information when preparing in vitro DC-activated CD8+ T cells for adoptive T cell therapy of cancer. | Zhenmin Ye Chaoke Tang Shulin Xu Bei Zhang Xueshu Zhang Terence Moyana Jicheng Yang Jim Xiang | 2007 | Cellular & Molecular Immunology2007，4，4： | 8 |
| 2 | Identification,bioinformatic analysis and expression profiling of candidate mRNA-like non-coding RNAs in Sus scrofa显示文摘Messenger RNA-like non-coding RNAs(mlncRNAs) are a newly identified group of non-coding RNAs(ncRNAs) that may be in-volved in a number of critical cellular events.In this study,93 candidate porcine mlncRNAs were obtained by computational prediction and screening,among which 72 were mapped to the porcine genome.Further analysis of 8 representative candidates revealed that these mlncRNA candidates are not highly conserved among species.Remarkably,one of the candidates,sTF35495,was found to be precursor of a putative porcine microRNA.By RACE PCR,we determined that the full length of sTF35495 was 3 kb.The protein-coding potential of this RNA was tested in silico with no significant finding.Semi-quantitative RT-PCR analysis of the subgroup of 8 candidates revealed two distinct expression profiles and two molecules were further validated by real-time PCR.The predicted pre-microRNA sequence in this study provides a potentially interesting insight into the in vivo function of porcine mlncRNAs and our findings suggest that they play key biological roles in Sus scrofa. | Bang Xiao Xingju Zhang Yong Li Zhonglin Tang Shulin Yang Yulian Mu Wentao Cui Hong Ao Kui Li | 2009 | Journal of Genetics and Genomics2009，36，12： | 7 |
| 3 | Aptamer-wrapped gold nanoparticles for the colorimetric detection of omethoate显示文摘Organophosphorous pesticide(OP) contamination has serious adverse effects on human health and the environment. Due to the toxicity of OPs and the threat presented by their accidental or intentional release in populated areas, the determination and monitoring of these OPs in food products and environment is of great importance. OPs are present in very small quantities and therefore, methods for their detection need to be highly sensitive and selective. Here, we aimed to develop a simple and selective aptamer-based colorimetric assay for the detection of omethoate, which is one of the commonly used OPs. The principle of the assay is that single-stranded DNA(ss DNA)-wrapped gold nanoparticles(Au NPs) are resistant to salt-induced aggregation. By employing an 'artificial antibody' organophosphorous pesticide-binding aptamer(OBA) as the recognition element, aptamer-wrapped Au NPs(Au-apta) show high selectivity towards omethoate, resulting in the disconnection of aptamers from Au NPs and the aggregation of Au NPs. As there is a significant color change from the interparticle plasmon coupling during the aggregation of Au NPs, the established assay showed good linearity between 0.1 and 10 μmol/L, with a low detection limit of 0.1 μmol/L. Other OPs such as profenofos, phorate, and isocarbophos would not interfere with the detection of omethoate despite having similar structures. Thus, the colorimetric method shows potential for use in the detection of omethoate in real soil samples. | Pengjuan Wang Ying Wan Aldalbahi Ali Shengyuan Deng Yan Su Chunhai Fan Shulin Yang | 2016 | Science China Chemistry2016，59，2： | 6 |
| 4 | Optical meta-waveguides for integrated photonics and beyond显示文摘The growing maturity of nanofabrication has ushered massive sophisticated optical structures available on a photonic chip.The integration of subwavelength-structured metasurfaces and metamaterials on the canonical building block of optical waveguides is gradually reshaping the landscape of photonic integrated circuits,giving rise to numerous metawaveguides with unprecedented strength in controlling guided electromagnetic waves.Here,we review recent advances in meta-structured waveguides that synergize various functional subwavelength photonic architectures with diverse waveguide platforms,such as dielectric or plasmonic waveguides and optical fibers.Foundational results and representative applications are comprehensively summarized.Brief physical models with explicit design tutorials,either physical intuition-based design methods or computer algorithms-based inverse designs,are cataloged as well.We highlight how meta-optics can infuse new degrees of freedom to waveguide-based devices and systems,by enhancing light-matter interaction strength to drastically boost device performance,or offering a versatile designer media for manipulating light in nanoscale to enable novel functionalities.We further discuss current challenges and outline emerging opportunities of this vibrant field for various applications in photonic integrated circuits,biomedical sensing,artificial intelligence and beyond. | Yuan Meng Yizhen Chen Longhui Lu Yimin Ding Andrea Cusano Jonathan A.Fan Qiaomu Hu Kaiyuan Wang Zhenwei Xie Zhoutian Liu Yuanmu Yang Qiang Liu Mali Gong Qirong Xiao Shulin Sun Minming Zhang Xiaocong Yuan Xingjie Ni | 2021 | Light(Science & Applications)2021，10，12： | 6 |
| 5 | Space-confined growth of monolayer ReSe2 under a graphene layer on Au foils显示文摘Vertical heterostructures based on two-dimensional(2D)materials have attracted widespread interest for their numerous applications in electronic and optoelectronic devices.Herein,we report the direct construct!on of an abnormal graphene/ReSe2 stack on Au foils by a two-step chemical vapor deposition(CVD)strategy.During the second growth stage,mono layer ReSe2 is found to prefere ntially evolve at the irUerface between the first-grown graphene layer and the Au substrate.The unusual stacking behavior is unraveled by in-situ'cutting open'the upper graphene from the defects to expose the lower ReSe2 using scanning tunneling microscopy(STM).From combination of these results with density functional theory calculations,the domain boundaries and edge sites of graphene are proposed to be adsorption sites for Re and Se precursors,further facilitating the growth of ReSe2 at the van der Waals gap of graphene/Au.This work hereby offers an intriguing strategy for obtaining vertical 2D heterostructures featured with an ultra-clean interface and a designed stacking geometry. | Chunyu Xie Shaolong Jiang Xiaolong Zou Yuanwei Sun Liyun Zhao Min Hong Shulin Chen Yahuan Huan Jianping Shi Xiebo Zhou Zhepeng Zhang Pengfei Yang Yuping Shi Porun Liu Qing Zhang Peng Gao Yanfeng Zhang | 2019 | Nano Research2019，12，1： | 4 |
| 6 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 7 | Effects of cerium substitution on phase components, microstructures and magnetic properties of Nd-Fe-Ti-B alloy显示文摘(Nd(1-x)Cex)(12)Fe(77)Ti5B6(x=0,0.2,0.3,0.4,0.6,0.8)alloys were prepared by melt-spinning and annealing techniques.The phase constitutions,microstructures and magnetic properties were investigated by powder X-ray diffraction(XRD),a differential scanning calorimeter(DSC),a vibrating sample magnetometer(VSM)and a transmission electron microscope(TEM).It is found that with the increase of Ce content,the coercivity of the(Nd(1-x)Cex)(12)Fe(77)Ti5B6 alloys reaches maximum first and then decreases.The maximum coercivity reaches 18.5 kOe obtained in the sample of 20%Ce substituted which is 34%higher than the Ce-free sample.TEM results reveal that the micro structure refinement effect is responsible for the coercivity improvement.This phenomenon implies that in some cases,Ce and Ti co-doping is more beneficial to improving of the coercivity than Ti single doping in Nd-Fe-B alloys.With further Ce addition,magnetic properties deteriorate due to the formation of CeFe2 and TbCu7-type phases. | Haijun Peng Yang Luo Yakun Dou Xinyuan Bai Wenlong Yan Dunbo Yu Yuanfei Yang Shulin Diao | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 8 | CXCL16 deficiency attenuates acetaminopheninduced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice显示文摘Chemokine C-X-C ligand 16 (CXCL16 ) ,一种单个通行证的类型我属于 CXC chemokine 家庭的膜蛋白质,与在肝损害的煽动性的反应有关。在现在的学习,我们调查了 CXCL16 的 pathophysiological 角色,唯一的膜界限 chemokine,在导致的 acetaminophen (APAP ) 在老鼠的 hepatotoxicity。老鼠与 APAP 被注射,并且血和织物样品在不同时间点被收获。浆液高活动性的组盒子 1 并且 CXCL16 层次被三明治免疫分析确定。肝织物节与 hematoxylin 曙红或与染色的 dihydroethidium 被染色。CXCL16 和另外的 cytokines 的表情被即时聚合酶链反应检验。Ly6-B, p-jun N 终端 kinase (p-JNK ) ,和 JNK 表情被西方的污点分析测量。细胞内部的谷胱甘肽,反应的氧种类,和 malondialdehyde 层次也被测量。APAP 服药过量增加了肝的 CXCL16 mRNA 和浆液 CXCL16 蛋白质层次。CXCL16 缺乏的老鼠显著地展出了更少的肝损害和肝的坏死,以及更低的死亡比野类型(WT ) 响应 APAP 服药过量处理的老鼠。提高的 APAP 在 WT 老鼠的呼吸的链激活,它是强烈在 CXCL16 大美人老鼠颠倒了的氧化应力和减少的 mitochondrial 的生产。另外, CXCL16 缺乏禁止了嗜中性的渗入和 APAP 服药过量处理触发的 proinflammatory cytokines 的生产。我们的学习表明 CXCL16 是对导致 APAP 的 hepatotoxicity 的肝免疫者反应的一个批评管理者,因此由指向 CXCL16 为导致药的尖锐的肝失败的处理提供潜在的策略。 | Hong Wang Yihui Shao Saisai Zhang Anqi Xie Yanna Ye Lihua Shi Leigang Jin Xuebo Pan Zhuofeng Lin Xiaokun Li Shulin Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 4 |
| 9 | Effect of Phosphorus on Mechanical Properties and Thermal Stability of Fine-grained GH761 Alloy显示文摘The effect of phosphorus on mechanical properties and thermal stability of fine-grained GH761 alloy has been investigated.The results show that,when the content of phosphorus is in the range of 0.0007-0.040,there are no significant effects on the tensile properties.Phosphorus strongly affects the stress rupture life.The content of 0.023 P results in the longest life in this experiment.Compared with that of the alloy with 0.0007 P,the life is increased more than 2 times in the alloy with 0.023 P.After ageing at 700℃ for 1000 h,the life reduced to some extent.However,phosphorus exhibits the similar effect on the life as before ageing.The tensile properties of the alloy are not influenced by long term ageing obviously.The present results suggested that the optimum content of phosphorus is 0.023.The phosphorus with this content can optimize the precipitates at the grain boundaries and prevent the excessive growth of the precipitates.The combining mechanical properties of GH761 alloy can be largely improved by phosphorus addition combined with grain refinement. | Shulin Yang Wenru Sun Jianxi Wang Zhimei Ge Shouren Guo Zhuangqi Hu | 2011 | Journal of Materials Science & Technology2011，27，6： | 3 |
| 10 | Experimental Investigation on Convective Heat Transfer Characteristics in Ribbed Channel显示文摘The heat transfer and pressure loss characteristics on a square channel with two opposite surfaces roughened by high blockage ratio ribs are measured by systematic experiments.Reynolds numbers studied in the channel range from 1 400 to 8 000.The ratios of rib height to hydraulic diameter (e/D) are 0.2and 0.33,respectively.The ratio of rib spacing to height (P/e) ranges from 5to 15.The rib orientations in the opposite surfaces are symmetrical and staggered arrangements.The results show that the heat transfer coefficients are increased with the increase of rib height and Reynolds number,though at the cost of higher pressure losses.When the rib spacing to height ratio is 10,it keeps the highest heat transfer coefficient in three kinds of rib spacing to height ratios 5,10 and 15.The heat transfer coefficient of symmetrical arrangement ribs is higher than that of the staggered arrangement ribs,but the pressure loss of the symmetrical arrangement ribs is larger than that of the staggered arrangement ribs. | Xie Changtan Xue Shulin Yang Weihua | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，6： | 2 |
| 11 | Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China显示文摘The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution. | Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-Feng Chen Zenghua Qi Zongwei Cai | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 12 | Amelioration of weld-crack resistance of the M951 superalloy by engineering grain boundaries显示文摘Fusion weld is a portable and economical joining and repairing method of metals.However,weld cracks often occur during the fusion weld of Ni-base superalloys,which hinder the applications of fusion weld on this kind of materials.In this work,the effects of microstructures of grain boundaries(GBs)of the prototype M951 superalloy on its weldability were investigated.The precipitated phases,the elemental segregations on GBs,and the morphologies of GBs can be largely altered by regulating the cooling rates of pre-weld heat treatments.With decreasing the cooling rate,chain-like M_(23)X_(6)phase precipitates along the GBs,accompanying segregations of B,and GBs becomes more serrated in morphology.During fusion weld,the engineered GBs in the M951 superalloy with a low cooling rate favor the formation of the continuous liquid films on GBs,which together with the serrated GB morphology significantly prevents the formation of weld cracks.Our findings imply that the weld-crack resistance of the superalloys can be ameliorated by engineering GBs. | Mingyue Wen Yuan Sun Jinjiang Yu Shulin Yang Xingyu Hou Yanhong Yang Xiaofeng Sun Yi Zhou Zhou | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 13 | A novel superconducting quantum interference device for biomagnetic measurements显示文摘Superconducting Quantum Interference Device (SQUID) can provide an ultrahigh magnetic sensitivity for the biomagnetic measurements. In this paper, a SQUID bootstrap circuit (SBC) gradiometer was designed and fabricated. Using the SBC gradiometer, magnetocardiography (MCG), fetal MCG and magnetoencephalography (MEG) signals were detected in a magnetically shielded room. | ZHANG ShuLin ZHANG GuoFeng WANG YongLiang ZENG Jia QIU Yang LIU Ming KONG XiangYan XIE XiaoMing | 2013 | Chinese Science Bulletin2013，58，24： | 2 |
| 14 | Toughening of poly (butylene terephthalate) with epoxy-functionalized acrylonitrile butadiene-styrene 显示文摘 | Sun Shulin Xu Xinyu Yang Haidong | 2005 | Polymer2005，46，18： | 1 |
| 15 | Developing laminar morphology in higher-viscosity-ratio polyblends by controlling flow fields in a single-screw extruder显示文摘 | Huang Hanxiao Huang Youfa Yang Shulin | 2005 | Polym Int2005，54，1： | 1 |
| 16 | In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides显示文摘The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7]. | Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 17 | Toughening of poly ( butylene terephthalate ) with epoxy-functionalized acrylonitrile-butadiene-styrene 显示文摘 | SUN Shulin XU Xinyu YANG Haidong | 2005 | Polymer2005，46，18： | 1 |
| 18 | Comparative Study of Outcome in Treating Upper Ureteral Impacted Stones Using Minimally Invasive Percutaneous Nephrolithotomy With Aid of Patented System or Transurethral Ureteroscopy显示文摘 | Zhongsheng Yang Leming Song Donghua Xie Min Hu Zuofeng Peng Tairong Liu Chuance Du Jiuqing Zhong Wen Qing Shulin Guo Lunfeng Zhu Lei Yao Jianrong Huang Difu Fan Zhangqun Ye | 2012 | Urology2012，，6： | 1 |
| 19 | Application of Heuristic Graph Search to Test Points Selection for Analog Fault Dictionary Techniques 显示文摘 | Yang Chenglin Tian Shulin Long Bing | 2009 | IEEE Transac- tions on Instrumentation and Measurement2009，58，7： | 1 |
| 20 | THE LARGEST EIGENVALUE DISTRIBUTION OF THE LAGUERRE UNITARY ENSEMBLE显示文摘We study the probability that all eigenvalues of the Laguerre unitary ensemble of n by n matrices are in(0, t), that is, the largest eigenvalue distribution. Associated with this probability, in the ladder operator approach for orthogonal polynomials, there are recurrence coefficients, namely, α_n(t) and β_n(t), as well as three auxiliary quantities, denoted by r_n(t), R_n(t), and σ_n(t). We establish the second order differential equations for both β_n(t) and r_n(t). By investigating the soft edge scaling limit when α = O(n) as n →∞ or α is finite, we derive a P_Ⅱ, the σ-form, and the asymptotic solution of the probability. In addition, we develop differential equations for orthogonal polynomials P_n(z) corresponding to the largest eigenvalue distribution of LUE and GUE with n finite or large. For large n,asymptotic formulas are given near the singular points of the ODE. Moreover, we are able to deduce a particular case of Chazy's equation for ρ(t) = Ξ′(t) with Ξ(t) satisfying the σ-form of P_Ⅳ or P_Ⅴ. | Shulin LYU Yang CHEN | 2017 | Acta Mathematica Scientia2017，37，2： | 1 |
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