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| 1 | Effects of methotrexate on the developments of heart and vessel in zebrafish显示文摘Methotrexate (MTX ) , folic 酸的一个对手,能禁止在 tetrahydrofolic 酸和胚胎的开发的合成很重要的 dihydrofolate reductase (DHFR ) 。在这研究,我们在暴露于 1.5 以后发现了那 ? 在 610 个小时的公里 MTX 授精以后, zebrafish 胚胎没能形成正常心血管的系统。在对待 MTX 的胚胎,室和中庭的词法发展被破坏,心脏的扭曲是反常的,心率和室的弄短部分被减少,并且脉管的发展被破坏。我们也与钙盐五水合物(CF ) 能在对待 MTX 的胚胎在心和容器引起改进开发的 folinic 酸与 dhfrgfp mRNA 或处理发现那任何一个 microinjection,它证明那 MTX 由禁止 DHFR 导致了畸形性。象 hand2, mef2a, mef2c,和 flk-1 那样的基因的抄本层次在对待 MTX 的胚胎被减少。与对待 MTX 的组相比, hand2, mef2a, mef2c,和 flk-1 的抄本层次在 MTX + dhfrgfp 被增加注射 mRNA 的组并且在 MTX + CF 组。我们的结果显示在对待 MTX 的胚胎的心和容器的破坏发展与 hand2, mef2a, mef2c,和 flk-1 的减少的抄本层次有关。 | Shuna Sun Yonghao Gui Yuexiang Wang Linxi Qian Xuefei Liu Qiu Jiang Houyan Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 10 |
| 2 | Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish显示文摘Folic 酸为抑制能在脊椎动物引起先天的心缺点的胚胎的开发和 folic 酸是很重要的。Dihydrofolate reductase (DHFR ) 是在叶酸调停新陈代谢的关键酶。DHFR 的机能障碍破坏酸参予 folic 的关键生物过程。DHFR 基因在脊椎动物进化期间被保存。在心脏的开发调查 DHFR 的角色是重要的。在这研究,我们显示出那 DHFR 击倒在早阶段导致了 zebrafish 胚胎的反常开发。在心和流出道的明显的畸形性(经常) 也在 DHFR 击倒的胚胎被观察。DHFR overexpression 在 DHFR 击倒的组救了反常显型。DHFR NKX2.5 的表达式上的击倒的有的否定影响(NK2 抄写因素相关 5 ) , MEF2C (myocyte 特定的 enhancer 因素 2C ) , TBX20 (T 盒子 20 ) ,并且 TBX1 (T 盒子 1 ) 它在心脏的开发过程期间是重要 transcriptional 因素,当 DHFR overexpression 有积极效果时。DHFR 为刺猬小径被要求。DHFR 击倒的引起的减少的房间增长和增加的 apoptosis,当它的 overexpression 支持了房间增长并且禁止了 apoptosis 时。一起拿,我们的学习建议 DHFR 由调整基因抄写并且影响房间增长和 apoptosis 在 zebrafish 在心并且经常的发展起关键作用。 | Shuna Sun Yonghao Gui Qiu Jiang Houyan Song | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 5 |
| 3 | Study of the Reaction Between the Nucleic Acid and Y-BPMPHD-CTMAB Complex and Its Analytical Application显示文摘 | Xia Wu Shuna Sun Jinghe Yang Yuebo Wang Yuxiang Li Benyu Su | 2004 | Journal of Fluorescence2004，，1： | 1 |
| 4 | Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos显示文摘Fetal alcohol syndrome(FASD)describes a range of birth defects.Mechanisms of FASD-associated defects are not well understood.It has great significance to investigate whether nutrient sup-plements like folic acid(FA)can effectively rescue etha nol-induced defects.Moreover,it is very important to determine the optimal time for FA supplementation when it can most effectively antagonize the teratogenic effects of ethanol during embryonic development.Our results indicated that ethanol exposure interrupted the development of zebrafish embryos and induced multiple defects in cardiac function,pharyngeal arch arteries,vessel,craniofacial cartilage,pharyngeal arches,brain,somite and hemoglobin formation.The expressions of critical genes that play important roles in above organs such as tbx1,flk-1,|hand2,ngn1,huc,titin,gata-1 and c-myb were reduced,and the apoptosis was increased in ethanol-treated group.FA supplementation could reverse ethanol-induced defects,improve the decreased expressions of above genes and reduce the apoptosis.We also found that giving FA at 6-12 h post-fertilization(hpf),which is at the gastrula period(5.25--10 hpf),can obviously prevent the teratogenicity of ethanol.This research provides clues for elucidating the mechanism of fetal abnormalties caused by alcohol intake and for preventing FASD. | Qiu Jiang Ding Lu Feng Wang Yawen Zhang Li Cao Yonghao Gui Shuna Sun | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 1 |
| 5 | Interfacial synergistic effect in SnO_(2)/PtNi nanocrystals enclosed by high-index facets for high-efficiency ethylene glycol electrooxidation显示文摘Strengthening the oxide-metal interfacial synergistic interaction in nanocatalysts is identified as potential strategy to boost intrinsic activities and the availability of active sites by regulating the surface/interface environment of catalysts.Herein,the SnO_(2)/PtNi concave nanocubes(CNCs)enclosed by high-index facets(HIFs)with tunable SnO_(2)composition are successfully fabricated through combining the hydrothermal and self-assembly method.The interfacial interaction between ultrafine SnO_(2)nanoparticles and PtNi with HIFs surface structure is characterized by analytical techniques.The as-prepared 0.20%SnO_(2)/PtNi catalyst exhibits extraordinarily high catalytic performance for ethylene glycol electrooxidation(EGOR)in acidic conditions with specific activity of 3.06 mA/cm^(2),which represents 6.2-fold enhancement compared with the state-of-the-art Pt/C catalyst.Additionally,the kinetic study demonstrates that the strong interfacial interaction between SnO_(2)and PtNi not only degrades the activation energy barrier during the process of EGOR but also enhances the CO-resistance ability and long-term stability.This study provides a novel perspective to construct highly efficient and stable electrocatalysts for energy conversions. | Shuna Li Haixiao Sun Jiaai Zhang Longjiao Zheng Yunrui Li Xu Fang Yujie Liu Qi Song Zhen Wang Yufeng Gao Xin Zhang Xiaoping Dai Yandi Cai Fei Gao | 2022 | Nano Research2022，15，9： | 0 |
| 6 | Synthesis and mechanical and elevated temperature tribological properties of a novel high-entropy(TiVNbMoW)C_(4.375) with carbon stoichiometry deviation显示文摘High-entropy carbides are a nascent group of ceramics that are promising for high-temperature applications due to the combination of good stability,high hardness(H),high strength,and superior creep resistance that they display.Due to high melting points and low lattice diffusion coefficients,however,the high-entropy carbides are usually difficult to consolidate to a nearly full density.To cope with this challenge,herein,binary carbides including TiC,V_(8)C_(7),NbC,Mo_(2)C,and WC with different carbon stoichiometry were used to prepare dense high-entropy(TiVNbMoW)C_(4.375),and the influence of carbon vacancy on formation ability and mechanical properties of carbon-deficient high-entropy(TiVNbMoW)C_(4.375) were investigated.Intriguingly,although the starting binary carbides have different crystal structures and carbon stoichiometry,the as-prepared high-entropy material showed a rock-salt structure with a relatively high density(98.1%)and good mechanical properties with hardness of 19.4±0.4 GPa and fracture toughness(KIC)of 4.02 MPa·m^(1/2).More importantly,the high-entropy(TiVNbMoW)C_(4.375) exhibited low coefficient of friction(COF)at room temperature(RT)and 800℃.Wear rate(W)gradually increased with the temperature rising,which were attributed to the formation of low-hardness oxidation films at high temperatures to aggravate wear.At 800℃,lubricating films formed from sufficient oxidation products of V_(2)O_(5) and MoO_(3) effectively improved tribological behavior of the high-entropy(TiVNbMoW)C_(4.375).Wear mechanisms were mainly abrasive wear resulting from grain pullout and brittle fracture as well as oxidation wear generated from high-temperature reactions.These results are useful as valuable guidance and reference to the synthesis of high-entropy ceramics(HECs)for sliding parts under high-temperature serving conditions. | Jicheng LI Yanchun ZHOU Yunfeng SU Shuna CHEN Qiuan SUN Hengzhong FAN Junjie SONG Litian HU Yongsheng ZHANG | 2023 | Journal of Advanced Ceramics2023，12，2： | 0 |
| 7 | PtNiCu nanowires with advantageous lattice-plane boundary for enhanced ethanol electrooxidation显示文摘It is generally accepted that the interface effect and surface electronic structure of catalysts have vital impact on catalytic properties.Understanding and tailoring the atomic arrangement of interface structure are of great importance for electrocatalysis.Herein,we proposed a simple method to synthesize etching-PtNiCu nanowires(e-PtNiCu NWs)enclosed by both(110)and(100)facets evolving from PtNiCu nanowires(PtNiCu NWs)mainly with(111)facets by selectively etching process.After acetic acid etching treatment,the e-PtNiCu NWs possess high total proportions(88.3%)of(110)and(100)facets,whereas the(111)facet is dominant in PtNiCu NWs(64%)by qualitatively and quantitatively evaluation.Combining the structure characterizations and performance tests of ethanol electrooxidation reaction(EOR),we find that the e-PtNiCu NWs display remarkably performance for EOR,which is nearly 4.5 times and 1.5 times enhancement compared with the state-of-the-art Pt/C catalyst,as well as 2.2 and 1.4 times of PtNiCu NWs,in specific activity and mass activity,respectively.The improved performance of e-PtNiCu NWs is attributed to synergistic catalytic effect between(110)and(100)facets that not only significantly decreases the onset potentials of adsorbed CO(CO_(ads))but also favors the oxidation of CO_(ads)on the surface of catalyst.Furthermore,thermodynamics and kinetic studies indicate that the synergistic effect of both(110)and(100)facets in e-PtNiCu NWs can decrease the activation energy barrier and facilitate the charge transfer during the reaction.This work provides a promising approach to construct catalysts with tunable surface electronic structure towards efficient electrocatalysis. | Shuna Li Yao Wang Yunrui Li Xu Fang Yujie Liu Mingxuan Li Zhen Wang Yufeng Gao Haixiao Sun Fei Gao Xin Zhang Xiaoping Dai | 2022 | Nano Research2022，15，4： | 0 |
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