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| 1 | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies显示文摘Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages:(i) triggering,(ii) maturation,(iii) targeting, and(iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies(including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. | Qiang Guo Yuxiang Wang Dan Xu Johannes Nossent Nathan J.Pavlos Jiake Xu | 2018 | Bone Research2018，6，2： | 71 |
| 2 | Nitrogen removal characteristics of heterotrophic nitrification-aerobic denitrification by Alcaligenes faecalis C16显示文摘Alcaligenes faecalis C16 was found to have the ability to heterotrophically nitrify and aerobically denitrify. In order to further understand its nitrogen removal ability and mechanism, the growth and ammonium removal response were investigated at different C/N ratios and ammonium concentrations in the medium with citrate and acetate as carbon source separately. Furthermore, experiments of nitrogen sources, production of nitrogen gas and enzyme assay were conducted. Results show that the bacterium converts NH+4-N and produces NH2 OH during the growing phase and nitrite accumulation is its distinct metabolic feature. A. faecalis C16 is able to tolerate not only high ammonium concentration but also high C/N ratio, and the ammonium tolerance is associated with carbon source and C/N ratio. The nitrogen balance under different conditions shows that approximately28%–45% of the initial ammonium is assimilated into the cells, 44%–60% is denitrified and several percent is converted to nitrification products. A. faecalis C16 cannot utilize hydroxylamine, nitrite or nitrate as the sole nitrogen source for growth. However, nitrate can be used when ammonium is simultaneously present in the medium. A possible pathway for nitrogen removal by C16 is suggested. The preliminary enzyme assay provides more evidence for this nitrogen removal pathway. | Yuxiang Liu Yao Wang Yi Li Hua An Yongkang Lv | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 27 |
| 3 | The strengthening East Asia summer monsoon since the early 1990s显示文摘Previous studies have documented a weakening tendency of the East Asian summer monsoon (EASM) since the end of the 1970s. In this study, we report that the EASM has been recovering since the early 1990s, although its strength is still less than in previous decades (averaged over the period 1965-1980). Following the recovery of the EASM, there has been a tendency in the last decade toward northward-moving rainbands and excessive rainfall in the Huaihe River valley (110°-120°E, 30°-35°N). There is evidence suggesting that the strengthening EASM since the early 1990s is linked to interdecadal change of land-sea thermal contrast. | LIU HaiWen ZHOU TianJun ZHU YuXiang LIN YiHua | 2012 | Chinese Science Bulletin2012，57，13： | 23 |
| 4 | Active corrosion protection of super-hydrophobic corrosion inhibitor intercalated Mg-Al layered double hydroxide coating on AZ31 magnesium alloy显示文摘Magnesium alloys,the advanced lightweight structural materials,have been successfully applied in the manufacturing field.Unfortunately,their poor corrosion resistance restrains the potential wide applications.In this work,anti-corrosion coatings were fabricated via the insitu growth of the corrosion inhibitors intercalated magnesium-aluminum layered double hydroxide(Mg-Al LDH)on AZ31 magnesium alloy and then post-sealing it by a super-hydrophobic coating.SEM,XRD,EDS,FTIR,XPS and contact angle test were conducted to analyze physical/chemical features of these coatings.Potentiodynamic polarization curves and electrochemical impedance spectroscopy were recorded to assess the anti-corrosion performance of prepared coatings.Surprisingly,Mg-Al LDH with molybdate intercalation and lauric acid modification achieves the excellent corrosion inhibition performance(99.99%)due to the multicomponent synergistic effect such as the physical protection of Mg-Al LDH,the corrosion inhibition of molybdate and super-hydrophobic properties of lauric acid.This work presents a scientific perspective and novel design philosophy to fabricate the efficient anti-corrosion coating to protect magnesium alloys and then expand their potential applications in other field. | Xin Wang Chuan Jing Yuxiang Chen Xiushuang Wang Gang Zhao Xing Zhang Liang Wu Xiaoying Liu Biqin Dong Yuxin Zhang | 2020 | Journal of Magnesium and Alloys2020，8，1： | 20 |
| 5 | HPR1000: Advanced Pressurized Water Reactor with Active and Passive Safety显示文摘HPR1000 is an advanced nuclear power plant(NPP)with the significant feature of an active and passive safety design philosophy,developed by the China National Nuclear Corporation.On one hand,it is an evolutionary design based on proven technology of the existing pressurized water reactor NPP;on the other hand,it incorporates advanced design features including a 177-fuel-assembly core loaded with CF3 fuel assemblies,active and passive safety systems,comprehensive severe accident prevention and mitigation measures,enhanced protection against external events,and improved emergency response capability.Extensive verification experiments and tests have been performed for critical innovative improvements on passive systems,the reactor core,and the main equipment.The design of HPR1000fulfills the international utility requirements for advanced light water reactors and the latest nuclear safety requirements,and addresses the safety issues relevant to the Fukushima accident.Along with its outstanding safety and economy,HPR1000 provides an excellent and practicable solution for both domestic and international nuclear power markets. | Ji xing Daiyong Song Yuxiang Wu | 2016 | Engineering2016，2，1： | 19 |
| 6 | Providing personalized converged services based on flexible network reconfiguration显示文摘Recent developments show a progressing convergence of networks, services, and applications, which results in the necessity for new approaches to provide a ubiquitous experience on converged networks for specialized high data-rate services. A fundamental diversifying attribute for the future physical network convergence paradigm is pressing. In this paper, we make researches on converged resource reconfiguration model of substrate physical network based on hardware virtualization and provide a service oriented network architecture as a network convergence primitive. Based on the idea of hardware virtualization which is performed by platform deformation and component processing with reconfiguration (here, they are realized as reconfigurable routers (RR)), the substrate converged network, which inter-connects various access networks by reconfigurable routers, could be mapped into multiplex service oriented logical networks, supports dynamic reconfiguration due to diversified quality of services under heterogeneous environment, and therefore provides more flexible and high- speed multiple services. In addition, to demonstrate the generality of our model, we provide a prototype of reconfigurable router. The design, implementation and task scheduling as well as both hardware and software reconfiguration process of reconfigurable router are discussed in detail. Our evaluation shows that reconfigurable router is transparent for upper service-providing networks and results in little performance impact on the service delivery when both hardware and software reconfiguration are used. | HU YuXiang LAN JuLong WU JiangXing | 2011 | Science China(Information Sciences)2011，54，2： | 15 |
| 7 | SOME FEATURES OF CARBON CYCLES IN KARST SYSTEM AND THE IMPLICATION FOR EPIKARSTIFICATION —An Example of Yaji Karst Experimental Site in Guilin,China显示文摘The carbon pools of biomass,littering,and SOC wre studied with regards to carbon cycles in epikarst zone,taking an example of Yaji Karst Experiemnt Site in Guilin.This study was focused on SOC and its lability,SOC decomposition rate,CO 2 regime in the soils. 13 ctracing was used to persua the relation of bicarbonate in karst water to soil carbon.The results indicated sufficient carbon pool in SOC for the driveing CO 2 in the karst system.It was revealed that about 60percent of carbon in epi-karst springs resulted from SOC during spring and summer.Thus,the CO 2,driving the karstification,was not simply due to adsorption of atmospheric CO 2 but due to carbon transfer through the pathway of air-plant-soil-water.The driving force should not be overlooked for the epi-karst formation by soil as an interface of carbon environmental geochemistry. | Pan Genxing Tao Yuxiang Shun Yuhua Teng Yongzhong Han Fushun College of Resource & Environment Science,Nanjing Agricultural Univ.,Nanjing, 210095 People’s Republic of China | 1997 | Journal of Geographical Sciences1997，7，3： | 15 |
| 8 | A multicenter,retrospective.epidemiologic survey of the clinical features and management of bone metastatic disease in China显示文摘Background:Bone metastases are common in patients with advanced cancer.Bisphosphonates(BPs) could prevent or delay the development of skeleton-related events(SREs).The present study aimed to identify the clinical features of and treatment strategies for Chinese patients with bone metastases.Methods:Consecutive cancer patients who had bone metastases and received BP treatment were enrolled.A questionnaire was developed to collect the patients' clinical data,as well as information on the diagnosis and management of bone metastases.Physicians' awareness of the guidelines and knowledge of the application of BP were also assessed.Results:A total of 3223 patients with lung cancer(36.5%),breast cancer(30.9%),prostate cancer(8.5%),and gastrointestinal cancer(5.7%) were included in this study.The sites of bone metastases were the thoracic spine(56.0%),lumbar spine(47.1%),ribs(32.6%),and pelvis(23.2%).The SRE frequency was the highest in patients with multiple myeloma(36.6%),followed by those with lung cancer(25.9%),breast cancer(20.2%),prostate cancer(18.2%),and gastrointestinal cancer(17.3%).Irradiation to the bone was the most frequent SRE(58%in lung cancer patients,45%in breast cancer patients,and 48%in prostate cancer patients).Our survey also showed that 45.5%of patients received BP within 3 months after their diagnosis of bone metastases,whereas the remaining 54.5%of patients did not receive BP treatment until at least 3 months after their diagnosis of bone metastases.The SRE frequency in the former group was significantly lower than that in the latter group(4.0%vs.42.3%,P < 0.05).In patients with more than 6 months of continuous BP treatment,the mean time to the first SRE was significantly longer than that in patients with less than 6 months of continuous BP treatment(7.2 vs.3.4 months,P < 0.05).In addition,12.2%of the physicians were not aware of the efficacy of BP in preventing and delaying SRE.Only half(52.3%) of the physicians agreed that the BP treatment should persist for at least 6 months unless it was intolerable.Conclusions:Our study suggested that prompt and persistent BP treatment was associated with a reduced risk of SREs.However,our survey also revealed that the proper application of BP was not as common as expected in China. | Yunpeng Yang Yuxiang Ma Jin Sheng Yan Huang Yuanyuan Zhao Wenfeng Fang Shaodong Hong Ying Tian Cong Xue Li Zhang | 2016 | Chinese Journal of Cancer2016，35，5： | 13 |
| 9 | Possible solutions for sludge dewatering in China显示文摘In China,over 1.43×10^(7)tons of dewatered sewage sludge,with 80%water content,were generated from wastewater treatment plants in 2007.About 60%of the COD removed during the wastewater treatment process becomes concentrated as sludge.Traditional disposal methods used by municipal solid waste treatment facilities,such as landfills,composting,or incineration,are unsuitable for sludge disposal because of its high water content.Disposal of sludge has therefore become a major focus of current environmental protection policies.The present status of sludge treatment and disposal methodology is introduced in this paper.Decreasing the energy consumption of sludge dewatering from 80%to 50%has been a key issue for safe and economic sludge disposal.In an analysis of sludge water distribution,thermal drying and hydrothermal conditioning processes are compared.Although thermal drying could result in an almost dry sludge,the energy consumption needed for this process is extremely high.In comparison,hydrothermal technology could achieve dewatered sewage sludge with a 50%–60%water content,which is suitable for composting,incineration,or landfill.The energy consumption of hydrothermal technology is lower than that required for thermal drying. | Wei WANG Yuxiang LUO Wei QIAO | 2010 | Frontiers of Environmental Science & Engineering2010，4，1： | 13 |
| 10 | BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis显示文摘BRASSINAZOLE-RESISTANT 1 family proteins(BZRs)are central transcription factors that govern brassinosteroid(BR)-regulated gene expression and plant growth.However,it is unclear whether there exists a BZR-independent pathway that mediates BR signaling.In this study,we found that disruption of all BZRs in Arabidopsis generated a hextuple mutant(bzr-h)displaying vegetative growth phenotypes that were almost identical to those of the null mutant of three BR receptors,bri1brl1brl3(bri-t).By RNA sequencing,we found that global gene expression in bzr-h was unaffected by 2 h of BR treatment.The anthers of bzr-h plants were loculeless,but a similar phenotype was not observed in bri-t,suggesting that BZRs have a BR signaling-independent regulatory role in anther development.By real-time PCR and in situ hybridization,we found that the expression of SPOROCYTELESS(SPL),which encodes a transcription factor essential for anther locule development,was barely detectable in bzr-h,suggesting that BZRs regulate locule development by affecting SPL expression.Our findings reveal that BZRs are indispensable transcription factors required for both BR signaling and anther locule development,providing new insight into the molecular mechanisms underlying the microsporogenesis in Arabidopsis. | Lian-Ge Chen Zhihua Gao Zhiying Zhao Xinye Liu Yongpeng Li Yuxiang Zhang Xigang Liu Yu Sun Wenqiang Tang | 2019 | Molecular Plant2019，12，10： | 11 |
| 11 | β-Catenin is important for cancer stem cell generation and tumorigenic activity in nasopharyngeal carcinoma显示文摘鼻咽的癌(NPC ) 在华南是有差的预后和复发的最普通的恶意的肿瘤之一。在诊所的 NPC 的难根除是主要由于癌症干细胞(CSC ) 。增加的证据表明 Wnt/-catenin 的异常激活断然与 CSC 的 produce 被相关。为了推进,在 NPC 在 CSC 和 tumorigenesis 上调查 -catenin 的效果,一根 CNE2 房间线(pLKO.1 嘘 -- catenin-CNE2 ) 在这研究与 -catenin 的稳定地压制的表示被使用。在包括象 E-cadherin 和 vimentin 一样的 c-myc, Nanog, Oct3/4, Sox2, EpCAM 以及粘附相关的蛋白质的 CSC 的 biomarkers 的表情被西方的污点分析并且 immunofluorescent 染色分析。增长和迁居能力被 MTT 试金和 Transwell 试金分别地调查。房间周期被流动 cytometry 分析。最后,异种皮移植被执行在 vivo 在 oncogenesis 上决定 -catenin 的效果。结果证明 c-myc, Nanog, Oct3/4, Sox2,和 EpCAM 的表情都被减少在 pLKO.1 嘘 -- catenin-CNE2 房间。vimentin 是 downregulated,这也被发现,当 E-cadherin 是 upregulated 时。MTT 和 Transwell 试金的结果建议增长和移植能力被 -catenin, 的 silencing 损害,更多的房间在 G1 阶段被逮捕什么时候与控制相比。在 vivo,学习显示肿瘤生长显著地在试验性的组被压制。把调查结果基于电流,当为移植的维护和 NPC 房间的增长能力的必要蛋白质,和由 c-myc, Nanog, Oct3/4, Sox2, EpCAM, E-cadherin, vimentin,和 -catenin 组成的一个复杂网络可以涉及固有的规定机制, -catenin 可以工作。 | Rui Jiang Xiaoshuang Niu Yuxiang Huang XiaoshengWang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 10 |
| 12 | Extremal functions for the Moser-Trudinger inequalities on compact Riemannian manifolds显示文摘Let (M, g) be a compact Riemannian manifold without boundary, and (N, g) a compact Riemannian manifold with boundary. We will prove in this paper that the ∫MudVg=o,sup∫M|(△↓)u|ndVg=1∫Meαn|u|n/n-1dVg,∫M(|(△↓)|n+|u|n)dVg=1∫Meαn|u|n/n-1dVg,and u|(e)N=0,∫Msup|(△↓)u|dVgN=1∫Neαn|u|n/n-1dVgn can be attained. Our proof uses the blow-up analysis. | LI Yuxiang Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China | 2005 | Science China Mathematics2005，48，5： | 10 |
| 13 | Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma:New opportunities towards molecularly targeted therapy显示文摘Esophageal cancer is one of the most lethal cancers worldwide because of its rapid progression and poor prognosis.Esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC)are two major subtypes of esophageal cancer.ESCC predominantly affects African and Asian populations,which is closely related to chronic smoking and alcohol consumption.EAC typically arises in Barrett’s esophagus with a predilection for Western countries.While surgical operation and chemoradiotherapy have been applied to combat this deadly cancer,molecularly targeted therapy is still at the early stages.With the development of large-scale next-generation sequencing,various genomic alterations in ESCC and EAC have been revealed and their potential roles in the initiation and progression of esophageal cancer have been studied.Potential therapeutic targets have been identified and novel approaches have been developed to combat esophageal cancer.In this review,we comprehensively analyze the genomic alterations in EAC and ESCC and summarize the potential role of the genetic alterations in the development of esophageal cancer.Progresses in the therapeutics based on the different tissue types and molecular signatures have also been reviewed and discussed. | Xu Zhang Yuxiang Wang Linghua Meng | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 9 |
| 14 | The progress and prospects of nebkhas in arid areas显示文摘Nebkhas 广泛地经常在干旱、半干旱的区域被散布,并且在这些区域在生态的环境的稳定起一个重要作用。这份报纸考察下列方面,包括形成和继任,空间分发,形状和表面气流特征,在侵蚀和免职之间的平衡,植被的生态、生理的特征,对降水和地下水的反应,土壤性质以及保护测量。我们发现没有继任时期的区别, nebkhas 被学习,并且塑造在时期不是的不同继任的动力学充分理解的特征,表面气流,土壤性质以及植被,它使向继任解释 nebkhas 和它的影响因素的动力学困难。当它在降级的生态系统的生态的功能被忽视时, nebkhas 的以前的研究作为陆地降级的指示物是为它的角色的 over-emphasized,它为在干旱、半干旱的区域的生态的恢复是相反的。未来研究应该在在不同影响因素之间的 nebkhas 和它的相互作用的继任对植被,土壤以及水文学过程的变化给予更多的注意。另外,在在干旱、半干旱的区域的降级的生态系统的 nebkhas 的积极角色应该充分被讨论。根据从上面得到的数据, nebkhas 的有效保护措施应该被探索。 | DU Jianhui YAN Ping DONG Yuxiang | 2010 | Journal of Geographical Sciences2010，20，5： | 9 |
| 15 | Field Measurements of Influence of Sand Transport Rate on Structure of Wind-sand Flow over Coastal Transverse Ridge显示文摘The structure of wind-sand flow under different total sand transport rates was measured with field vertical anemometer and sand trap on the crest of typical coastal transverse ridge in Changli Gold Coast of Hebei Province, which is one of the most typical coastal aeolian distribution regions in China and famous for the tall and typical coastal transverse ridges. The measurement results show that, on the conditions of approximate wind velocities and same surface materials and environments, some changes happen to the structure of wind-sand flow with the increase of total sand transport rate on the crest of coastal transverse ridge. First, the sand transport rates of layers at different heights in the wind-sand flow increase, with the maximum increase at the height layer of 4-8cm. Second, the ratios of sand trans-port rates of layers at different heights to total sand transport rate decrease at the low height layer (0-4cm), but increase at the high height layer (4-60cm). Third, the distribution of the sand transport rate in the wind-sand flow can be expressed by an exponential function at the height layer of 0-40cm, but it changes from power function model to ex-ponential function model in the whole height layer (0-60cm) and changes into polynomial function model at the height layer of 40-60cm with the increase of total sand transport rate. Those changes have a close relationship with the limit of sand grain size of wind flow transporting and composition of sand grain size in the wind-sand flow. | DONG Yuxiang S L NAMIKAS P A HESP MA Jun | 2008 | Chinese Geographical Science2008，18，3： | 9 |
| 16 | Observation and study on the whole process of cloud-to-ground lightning using narrowband radio interferometer显示文摘A narrowband radio interferometer has been developed and used to locate the entire sources of VHF radiations from a negative cloud-to-ground (CG) lightning discharge which contains 19 strokes. This system uses five antennas to form an array consisting of short- and long-baselines along two or- thogonal directions. The system error which comes from frequency conversion is reduced by phase detection through direct high frequency amplifying. An interactive graphic analysis procedure is used to remove the fringe ambiguities which exist inherently in interferometry and to determine the direction of lightning radiation sources in two dimensions (azimuth and elevation) as a function of time at a time resolution of microsecond orders. With the developed system, the whole progression process in time and space of a lightning flash can be reconstructed. In this paper, combining the synchronous data of electric filed change and VHF radiation, the whole processes of an example negative CG flash have been studied in detail. It is found that the preliminary breakdown event of the CG flash started from negative charge region and exhibited firstly a downward pregression and then an upward propagation. There were very intense and continuous radiations during stepped leaders which became much stronger when the first return stroke began. In contrast, there were less and only discrete radiations during dart leaders. Stepped leader and dart leader may transform to each other depending on the state of the ionization of the path. The progression speed of initial stepped leaders was about 105 ms?1, while that was about 4.1×106 and 6.0×106 ms?1 for dart leaders and dart-stepped leaders, respectively. M events produced hook-shaped field changes accompanied by active burst of radiations at their begin- nings. Followed these active radiation processes, M events appeared to contact finally into conducting main discharge channels. The mean progression speed of M events was about 7×107 ms?1, greater than that of the dart leaders and dart-step leaders. K events and attempted leaders were essentially the same as dart leaders except that they could not reach the ground and initiate return strokes. | ZHANG GuangShu ZHAO YuXiang QIE XiuShu ZHANG Tong WANG YanHui CHEN ChengPin | 2008 | Science China Earth Sciences2008，51，5： | 9 |
| 17 | Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress显示文摘Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chinese folk medicine for the human well-being.However,the actions of cordycepin against renal ischemia/reperfusion injury(/R)are still unknown.In the present study,rats were subject to VR and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal/R injury.The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury.Mechanistic studies showed that cordycepin significantly regulated inflammation,apoptosis,and oxidative stress.These data provide new insights for investigating the natural product with the nephroprotective effect against I/R,which should be developed as a new therapeutic agent for the treatment of I/R in the future. | Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 9 |
| 18 | OsCIPK7 point-mutation leads to conformation and kinase-activity change for sensing cold response显示文摘Calcineurin B-like interacting protein kinases(CIPKs) play important roles via environmental stress.However, less is known how to sense the stress in molecular structure conformation level. Here, an Os CIPK7 mutant via TILLING procedure with a point mutation in the kinase domain showed increased chilling tolerance, which could be potentially used in the molecular breeding. We found that this point mutation of Os CIPK7 led to a conformationalchange in the activation loop of the kinase domain,subsequently with an increase of protein kinase activity,thus conferred an increased tolerance to chilling stress. | Dajian Zhang Xiaoyu Guo Yunyuan Xu Hao Li Liang Ma Xuefeng Yao Yuxiang Weng Yan Guo Chun-Ming Liu Kang Chong | 2019 | Journal of Integrative Plant Biology2019，61，12： | 8 |
| 19 | Does conflict matter in the success of mass collaboration? Investigating antecedents and consequence of conflict in Wikipedia显示文摘Purpose: Web2.0 has facilitated the emergence of mass collaboration. Being a new model of virtual collaboration, mass collaboration has distinct characteristics such as self-organized voluntary participation and many-to-many communications mechanism. Behind the sparking achievements, mass collaboration systems are suffering from high coordination cost, reflecting intense conflict among the participants. This study explains how conflict interacts with its antecedents(participation and task complexity) and decedent(group performance) related to the mass collaboration process.Design/methodology/approach: Theoretical model is built upon literatures. Twenty-six measurable items, including social network indices used to reflect conflicts(e.g., density and degree), are extracted from Wikipedia database. The structural equation modeling is used to validate the proposed model.Findings: Participation increases task complexity, conflict and performance; task complexity and conflict increase group performance, but task complexity decreases conflict.Research limitations: This study is limited to one mass collaboration platform, other contexts can cause variance in the result. More characteristics of conflict network(e.g., self-loop)should be taken into consideration in future studies.Practical implications: Conflict management is critical to mass collaboration, and functions that increase the awareness of conflict may motivate users to participant, resulting better group performance.Originality/value: Few studies have investigated the consequences of conflict in mass collaboration context. Meanwhile, limited number of social network studies build network based on negative link. Moreover, most of extant studies on Wiki are descriptive researches without theoretical model. This study builds a theoretical model and incorporates social network approach to explore the influence of conflict. | Kewen WU Qinghua ZHU Julita VASSILEVA Yuxiang ZHAO | 2012 | Chinese Journal of Library and Information Science2012，，1： | 8 |
| 20 | Cationic content effects of biodegradable amphoteric chitosan-based flocculants on the flocculation properties显示文摘A series of biodegradable amphoteric chitosan-based flocculants(3-chloro-2-hydroxypropyl trimethyl ammonium chloride(CTA) modified carboxymethyl chitosan,denoted as CMC-CTA) with different substitution degrees of CTA were prepared successfully.The content of carboxymethyl groups in each CMC-CTA sample was kept almost constant.The solubility of the various flocculants showed that,higher cationic content of flocculants caused a better solubility.The flocculation experiments using kaolin suspension as synthetic water at the laboratory scale indicated that the substitution degree of CTA was one of the key factors for the flocculation properties.With the increase of cationic content,the flocculants were demonstrated better flocculation performance and lower dosage requirement.Flocculation kinetics model of particles collisions combining zeta potential and turbidity measurements was employed to investigate the effects of the cationic content of the flocculants on the flocculation properties from the viewpoint of flocculation mechanism in detail.Furthermore,flocculation performance using raw water from Zhenjiang part of Yangtze River at the pilot scale showed the similar effects to those at the laboratory scale. | Zhen Yang Yabo Shang Xin Huang Yichun Chen Yaobo Lu Aimin Chen Yuxiang Jiang Wei Gu Xiaozhi Qian Hu Yang Rongshi Cheng | 2012 | Journal of Environmental Sciences2012，24，8： | 8 |
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