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您的检索式：作者名="Shunjie Ding"
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| 1 | prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish显示文摘Prpf4(pre-mRNA processing factor 4),a key component of spliceosome,plays critical roles in pre-mRNA splicing and its mutations result in retinitis pigmentosa due to photoreceptor defects.In this study,we characterized a zebrafishharboring a Tol2 transposon-based gene trap cassette in the third intron of the prpf4 gene.Cells in the brain and spinal cord gradually undergo p53-dependent apoptosis after 28 hpf insuggesting that a widespread function of prpf4 in neural cell survival.In addition,prpf4 is essential for survival of posterior lateral line primordial(pLLP)cells.prpf4 deficiency perturbs Fgf,and chemokine signaling pathways and impairs pLLP migration.RNA-Seq analysis suggests that prpf4 deficiency may impair spliceosome assembly,leading to compensatory upregulation of core spliceosomal genes and alteration of pre-mRNA splicing.Taken together,our studies uncover an essential role of prpf4 in pre-m RNA splicing,cell survival and pLLP migration. | Yixia Wang Yanchao Han Pengfei Xu Shihui Ding Guangyuan Li Hongbin Jin Yaping Meng Anming Meng Shunji Jia | 2018 | Journal of Genetics and Genomics2018，45，8： | 1 |
| 2 | In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy显示文摘The copper(Ⅱ)diethyldithiocarbamate(Cu(DDC)2)complex exhibited excellent inhibition to cancer cells.The usual administration is intravenous injection for disulfram and oral for copper.A new strategy was reported to improve the administration efficiency of the Cu(DDC)2 drug.Poly(lactide-co-glycolide)(PLGA)nanoparticles were used to trap disulfram and copper gluconate separately,the two types of drug loaded nanoparticles were injected in mesothelioma-bearing nude mice via intraperitoneal injection.The in vivo formation of Cu(DDC)2 complex was induced by disulfiram and Cu^2+ released from PLGA nanoparticles.This stra tegy avoided many obstacles in the use of Cu(DDC)2 complex as chemothe rapeutic and exhibited excellent anticancer activity to mesothelioma. | Yixin Zhang Shunjie Ding Junhua Li Xinyu Peng Jing Li Jing Chang Wenxia Gao Bin He | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 3 | Breaking the responsivity-speed dilemma of a-GaO_(x) photodetector by alternating gate modulation显示文摘The gallium oxide(Ga_(2)O_(3))based photodetectors are usually confronted with the typical challenge of the responsivity-speed(RS)dilemma,namely high photocurrent induces a long decay time,as shown in Figure 1(a).The RS dilemma involves a trade-off issue,which is independent of photoelectric materials. | Zhongfang ZHANG Pengju TAN Xiaohu HOU Xiaolan MA Mengfan DING Shunjie YU Guangwei XU Xiaolong ZHAO Shibing LONG | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 4 | HIGH-RESOLUTION 35GHz COHERENT LFM-CW RADAR FOR TWO-DIMENSIONAL IMAGING显示文摘This paper presents the system design and experimental results of a 35GHz coherent LFM-CW radar for use in near range two-dimensional imaging. Special techniques, including FM sweep linearization, range-segment processing, system background voltage suppression and dynamic range compression are also presented. | Yang Jianyu Yang Xiaobo Ding Yiyuan Huang Shunji (Dept. of E. E., Microwave Center, Univ. of Electron. Sci. & Tech. of China, Chengdu 610054) | 1997 | Journal of Electronics(China)1997，14，2： | 0 |
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