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| 1 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 2 | miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells显示文摘在这研究,我们鉴别五 miRNAs 高度在小房间的肺癌症(SCLC ) 表示了房间线 NCI-H209。在他们之中, miR-375 的表示层次戏剧性地在检验的所有 SCLC 房间线被提高,与抄写因素 achaete 鳞甲建筑群相当或相同的事物的表示重合 1 (ASCL1 ) 。而且, miR-375 是 upregulated 并且在也从老鼠象 SCLC 一样肿瘤产生的房间线与 ASCL1 相关。双酶的试金进一步证明 ASCL1 在 miR-375 倡导者由绑定激活 miR-375 的表达式到三个电子盒子元素。这些结果经由 miR-375 的 upregulation 在 SCLC 暗示 ASCL1 的一个角色。 | Huijie Zhao Lei Zhu Yujuan Jin Hongbin Ji Xiumin Yan Xueliang Zhu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 6 |
| 3 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 4 | Dendritic BiVO4 decorated with MnOx co-catalyst as an efficient hierarchical catalyst for photocatalytic ozonation显示文摘An appropriate co-catalyst can significantly promote the photocatalytic efficacy, but this has been seldom studied in the visible-light photocatalysis combined with ozone, namely photocatalytic ozonation. In this work, a dendritic bismuth vanadium tetraoxide (BiVO4) material composited with highly dispersed MnOv nanoparticles was synthesized, and its catalytic activity is 86.6% higher than bare BiVO4 in a visible light and ozone combined process. Catalytic ozonation experiments, ultraviolet- visible (UV-Vis) diffuse reflectance spectra and photoluminescence spectra jointly indicate that MnOA plays a triple role in this process. MnOv strengthens the light adsorption and promotes the charge separation on the composite material, and it also shows good activity in catalytic ozonation. The key reactive species in this process is OH, and various pathways for its generation in this process is proposed. This work provides a new direction of catalyst preparation and pushes forward the application of photocatalytic ozonation in water treatment. | Jin Yang Xuelian Liu Hongbin Cao Yanchun Shi Yongbing Xie Jiadong Xiao | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 5 |
| 5 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 6 | Influence of nano-diamond content on the microstructure,mechanical and thermal properties of the ZK60 composites显示文摘The effect of nano diamond(ND)content on the microstructure,mechanical properties,and thermal conductivity of ZK60+x(x=0,0.05,0.1,0.15,0.2 wt.%)ND composites were investigated.The microstructures of ND/ZK60 composites were observed,which indicated that the nanoscale MgZn_(2) and ND particles distributed evenly in theα-Mg matrix.The tensile yield strength(TYS)and compressive yield strength(CYS)of the composites first increased remarkably and then decreased with further increasing the ND content.Due to the surface area of the matrix-diamond interface increased and the grains sizes of composites decreased with the amount of ND increase,which cause the coefficient of thermal expansion(CTE)of the composites reduced significantly.Meanwhile,the thermal conductivity of the composite material decreases from 129 W·m^(−1)·K^(−1) to 116 W·m^(−1)·K^(−1) with the content of ND increasing from 0.05%to 2.0%.The thermal conductivity of the composites increases to the maximum and then decrease with the increase of temperature(in temperature range of 273-573 K).The ZK60+0.05 ND showed superior mechanical and thermal conductivity property,TYS of 343.97 MPa,CYS of 341.74 MPa,elongation of 15.71%,CTE of 7.3×10^(−6)K^(−1),and thermal conductivity of 129 W·m^(−1)·K^(−1) at room temperature.It is demonstrated that the ND content has an obvious influence on the microstructure,mechanical properties,and thermal conductivity of ND/ZK60 composites. | Hongbin Ma Jinhui Wang Hongyu Wang Ningning Dong Junwei Zhang Peipeng Jin Yong Peng | 2022 | Journal of Magnesium and Alloys2022，10，2： | 3 |
| 7 | Electrochemistry during efficient copper recovery from complex electronic waste using ammonia based solutions显示文摘 | Zhi Sun Hongbin Cao Prakash Venkatesan Wei Jin Yanping Xiao Jilt Sietsma Yongxiang Yang | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 3 |
| 8 | Distinct synergetic effects in the ozone enhanced photocatalytic degradation of phenol and oxalic acid with Fe^(3+)/TiO_2 catalyst显示文摘In this work, phenol and oxalic acid(OA) degradation in an ozone and photocatalysis integrated process was intensively conducted with Fe^(3+)/TiO_2 catalyst. The ferrioxalate complex formed between Fe^(3+) and oxalate accelerated the removal of OA in the ozonation, photolysis and photocatalytic ozonation process, for its high reactivity with ozone and UV. Phenol was degraded in ozonation and photolysis with limited TOC removal rates, but much higher TOC removal was achieved in photocatalytic ozonation due to the generation of ·OH. The sequence of UV light and ozone in the sequential process also influences the TOC removal, and ozone is very powerful to oxidize intermediates catechol and hydroquinone to maleic acid. Fenton or photo-Fenton reactions only played a small part in Fe^(3+)/TiO_2catalyzed processes, because Fe^(3+) was greatly reduced but not regenerated in many cases.The synergetic effect was found to be highly related with the property of the target pollutants. Fe^(3+)/TiO_2 catalyzed system showed the highest ability to destroy organics, but the TiO_2 catalyzed system showed little higher synergy. | Yongbing Xie Yingying Chen Jin Yang Chenming Liu He Zhao Hongbin Cao | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 3 |
| 9 | Effect of Different Pretreatments on Explosion Puffing Drying of Hami Melon at Modified Temperature and Pressure in Xinjiang显示文摘This paper studies the influence of three different pretreatments( blanching,citric acid soaking,and Na Cl soaking) on the moisture content,degree of puffing,color,hardness and crispness of Hami melon under explosion puffing drying at modified temperature and pressure in Xinjiang. The results show that using 60 s blanching pretreatment can help to reduce the moisture content of puffed product while maintaining product color; 2. 5% citric acid pretreatment can make products maintain high degree of puffing and crispness,but reduce product color; 2%Na Cl penetrating fluid plays a significant role in maintaining product color,while maintaining crispness. | Wenting JIA Hui YANG Hongbin WU Hong WU Xinwen JIN | 2016 | Asian Agricultural Research2016，8，9： | 2 |
| 10 | EXPERIMENTAL STUDY ON SUPERFICIAL COAT OF GEARS OF NITRIDED 32Cr2MoV COATED WITH TiN FILM BY MULTI-ARC ION PLATING显示文摘在 32CrMoV 被选择生产与听 bymulti 弧离子 plating 涂的 nitrided 齿轮以后,所有这些非常在齿轮的 ated 齿轮和涂的齿轮跑在一样的起始的条件下面关以便有关性质和微观结构比较他们的差别。实验结果显示那牙齿表面涂 -- 听齿轮不在协调地区承受表面畸形。相反,有 nitrided 大小写的齿轮在牙齿表面的主题 hed 地区上展出一个磨损标记,它导致 nitrided 齿轮的更多的重量损失。表面的形态学建议有超过 2 000 HV 的听电影是那么稠密的并且弄平那涂 -- 听齿轮更高有穿抵抗与相比非常 ated 齿轮。微观结构涂 -- 听齿轮更好,坚硬更高并且它的分发涂 -- 听齿轮是更可靠的 thanuncoated,它使氮化物层紧与听电影相结合。因而,齿轮的 thewear 抵抗戏剧性地被支持了。 | LI Hui LI Runfang XU Hongbin ZHANG Jin | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 2 |
| 11 | Measuring boundary-layer height under clear and cloudy conditions using three instruments显示文摘 | Chenggang Wang Hongrong Shi Lianji Jin Hongbin Chen Huayang Wen | 2016 | Particuology2016，14，5： | 2 |
| 12 | A Putative Chloroplast-Localized Ca2+/H+ Antiporter CCHA1 Is Involved in Calcium and pH Homeostasis and Required for PSII Function in Arabidopsis显示文摘钙为叶绿体,不是在仅仅是重要的它的光合而且 nonphotosynthetic 功能。多重 Ca 2+/H+ transporters 和隧道在血浆膜和植物房间的细胞器膜被描述了并且学习;然而,分子的身份和叶绿体 Ca 2+/H+ antiporters 的生理的角色仍然保持未知。这里,我们报导 UPF0016 家庭,的一个成员的鉴定和描述 CCHA1 (叶绿体局部性的潜在的 Ca 2+/H+ antiporter ) ,在 Arabidopsis thaliana。我们观察到 ccha1 异种植物开发了苍白的绿叶子并且与损害 photosystem II (PSII ) 功能一起显示出严重地阻碍的生长。CCHA1 本地化到 PSII 核心子单元和演变氧的建筑群的叶绿体,和层次显著地与野类型相比在 ccha1 异种被减少。在高 Ca 2+ 集中, Arabidopsis CCHA1 部分救了酵母 gdt1 0 异种的生长缺点,它在 Ca 2+/H+ antiporter 是有缺点的。ccha1 异种植物也在 pH 显示出重要敏感到 CaCl 2 和 MnCl 2, 以及变化的高集中。一起拿这些结果,我们建议 CCHA1 可能在 Arabidopsis 与批评功能把通常认为的叶绿体局部性的 Ca 2+/H+ antiporter 编码为 PSII 的规定并且在叶绿体 Ca 2+ 和 pH 动态平衡。 | Chao Wang Weitao Xu Honglei Jin Taijie Zhang Jianbin Lai Xuan Zhou Shengchun Zhang Shengjie Liu Xuewu Duan Hongbin Wang Changlian Peng Chengwei Yang | 2016 | Molecular Plant2016，9，8： | 2 |
| 13 | Evidence fusion procedure based on hybrid DSm model显示文摘Dezert-Smarandache(DSm) theory, a new information fusion theory, is widely applied in image processing, multiple targets tracking identification, and other areas for its excellent processing ability of imperfect information. However, earlier research on DSm theory mainly focused on one sort of questions. An evidence fusion procedure is proposed based on the hybrid DSm model to compensate for a lack of research on the entire information procedure of DSm theory. This paper analyzes the evidence fusion procedure, as well as correlative node input and output information. Key steps and detailed procedures of evidence fusion are also discussed. Finally, an experiment illustrates the efficiency of the proposed evidence fusion procedure. | Hongfei Li Hongbin Jin Kangsheng Tian | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 2 |
| 14 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
| 15 | Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice显示文摘 | Wei Jin Hongbin Ni Yuxiang Dai Handong Wang Tianyu Lu Jun Wu Jian Jiang Weibang Liang Eric F. Morand | 2011 | Mediators of Inflammation2011，，： | 1 |
| 16 | Allograft versus autograft for anterior cruciate ligament reconstruction: an up-to-date meta-analysis of prospective studies显示文摘 | Jianzhong Hu Jin Qu Daqi Xu Jingyong Zhou Hongbin Lu | 2013 | International Orthopaedics2013，，2： | 1 |
| 17 | Optimization of Cottonseed Meal De-gossypol Process by Extrusion via Genetic Algorithm Based on Artificial Neural Network显示文摘[Objective] The paper aimed to optimize cottonseed meal de-gossypol process by extrusion. [Method]The artificial neural network( ANN) was used to stimulate the degradation of free gossypol in cottonseed meal by extrusion process,and a three-layer back propagation neural network was established to predict the degradation of free gossypol. [Result] The result of 10-fold cross validation showed that the ANN with the training function as traingdx at hidden layer with eight neurons gave the smallest mean square error( MSE). ANN predicted results were very close to the experimental results with correlation coefficient( R2) of0. 994 1 and RMSE of 0. 497 1. A genetic algorithm( GA) based on the established neural network model was also used for optimizing de-gossypol process. The results of GA showed that the optimal conditions of de-gossypol were puffing temperature 131℃,water ratio 51%,rotational speed 158 r / min,and feeding speed 136 kg / h,while under this condition the degradation rate of free gossypol was 90. 50%,which was close to the predicted result of GA with the small average relative error of 1. 38%. [Conclusion]These results suggested that the GA based on a neural network model might be an excellent tool for optimizing cottonseed meal de-gossypol process. | Zhang Qiang Wu Hongbin Jin Xinwen | 2016 | Animal Husbandry and Feed Science2016，8，1： | 1 |
| 18 | Comparison of curdlanand its carboxymethylated derivative by means of rheology,DSC,andAFM显示文摘 | JIN Yang ZHANG Hongbin YIN Yimei | 2006 | Carbohydrate Research2006，341，1： | 1 |
| 19 | Clinical outcomes of remnant preserving augmentation in anterior cruciate ligament reconstruction: a systematic review显示文摘 | Jianzhong Hu Jin Qu Daqi Xu Tao Zhang Jingyong Zhou Hongbin Lu | 2014 | Knee Surgery, Sports Traumatology, Arthroscopy2014，，9： | 1 |
| 20 | Comparison of curdlan and its earboxymethylated derivative by means of Rheology, DSC, and AFM显示文摘 | Yang Jin Zhang Hongbin Yin Yimei | 2006 | Carbohydrate Research2006，341，： | 1 |
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