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17篇 您的检索式：作者名="Sibaev"

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		题名	作者	年代	出处	被引量
	1	Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization显示文摘AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials(EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo. RESULTS: Nociceptin accelerated whole and upper GI transit, but slowed colonic expulsion in vivo in an ORL1-dependent manner, as shown using [Nphe1]NOC and AS ODN pretreatment. ORL1 and nociceptin immunoreactivity were found on enteric neurons. Nociceptin reduced the EJP and the nitric oxide-sensitive slow IJP in an ORL1-dependent manner, whereas the fast IJP was unchanged. Nociceptin further reduced the spatial spreading of the EJP up to 2 cm. CONCLUSION: Compounds acting at ORL1 are good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome.	Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr	2015	World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3：	2
	2	Role of the vagus nerve on the development of postoperative ileus显示文摘	Zhirong Gao Mario H. Müller Martina Karpitschka Sarah Mittler Michael S. Kasparek Bernhard Renz Andrej Sibaev J?rg Glatzle Yongyu Li Martin E. Kreis	2010	Langenbeck’s Archives of Surgery2010，，4：	1
	3	Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro 显示文摘	Storr M Koppitz P Sibaev A Saur D Kurjak M Franck H	2002	J Pineal Res2002，33，2：	1
	4	Melatonin reduces noradrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide syntheses activity in the gastrointestinal tract of rodents in vitro 显示文摘	Storr M Koppitz P Sibaev A	2002	J Pineal Res2002，33，2：	1
	5	The Chinese herbal preparation Qing Yi Tang (QYT) improves intestinal myoelectrical activity and increases intestinal transit during acute pancreatitis in rodents显示文摘	Li YY Sibaev A Zhou MZ	2007	Phytother Res2007，21，4：	1
	6	Intestinal Afferent Nerve Sensitivity is Increased During the Initial Development of Postoperative Ileus in Mice显示文摘	M. H. Mueller M. Karpitschka B. Xue M. S. Kasparek A. Sibaev J. Glatzle M. E. Kreis	2009	Journal of Gastrointestinal Surgery2009，，3：	1
	7	ORL-1 Receptor Mediates the Action of Nociceptin on Ascending Myenteric Reflex Pathways in Rats显示文摘	Birol Yüce Andrei Sibaev Andreas Haaken Dieter Saur Hans–Dieter Allescher Burkhard G?ke Jean–Pierre Timmermans Martin Storr	2007	Gastroenterology2007，，2：	1
	8	Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon显示文摘	Storr M Sibaev A Marsicano G Lutz B Schusdziarra V Timmermans JP	2003	Mol Pharmacol2003，63，：	1
	9	Melatonin reduces non-adrenergic,non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro显示文摘	Storr M Koppitz P Sibaev A	2002	J Pineal Res2002，33，：	1
	10	paration Qing Yi Tang (QYT) electrical activity and increases acute pancreatitis in rodents 显示文摘	Li Y Sibaev A Zhou M	2007	The Chinese herbal pre- improves intestinal myo- intestinal transit during Phytother Res2007，21，4：	1
	11	The cannabinoid‐1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice显示文摘	J. Fichna A. Sibaev M. Sa?aga M. Sobczak M. Storr	2013	Neurogastroenterol Motil2013，，8：	1
	12	Melatonin reduces non-adrenergic,non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro显示文摘	STORR M KOPPITZ P SIBAEV A	2002	J Pineal Res2002，33，2：	1
	13	The Chinese herbal preparation Qing Yi Tang (QYT) improves intestinal myoelectrical activity and increases intestinal transit during acute pancreatitis in rodents显示文摘	Li YY Sibaev A Zhou MZ		0，，4：	1
	14	Role of the vagus nerve on the development of postoperative ileus显示文摘	Zhirong Gao Mario H. Müller Martina Karpitschka Sarah Mittler Michael S. Kasparek Bernhard Renz Andrej Sibaev J?rg Glatzle Yongyu Li Martin E. Kreis	2010	Langenbeck’s Archives of Surgery2010，，4：	1
	15	Cannabinoid receptor typel modulates excitatory and inhibitory neurotransmission in mouse colon 显示文摘	Stoor M Sibaev A Marsicano G	2004	Am J Physiol Gastrointest Liver Physiol2004，286，1：	1
	16	The cannabinoid-1 ( CB-1 )receptor antagonist SR 14171a reduces intestinal afferent nerve sensitivity to painful stimuli in mice in vitro 显示文摘	Gong Q Mueler MH Sibaev A	2007	Gastroenterology2007，132，2：	1
	17	Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis 显示文摘	Massa F Sibaev A Marsicano G	2006	J Mol Med2006，84，2：	1

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