|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metalloproteinase expression after desflurane preconditioning in hepatectomies:A randomized clinical trial显示文摘BACKGROUND Hepatectomy with inflow occlusion results in ischemia-reperfusion injury;however,pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients.The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases,which may signal pathologic hepatic tissue reformation.AIM To investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.METHODS This is a single-center,prospective,randomized controlled trial conducted at the 4th Department of Surgery of the Medical School of Aristotle University of Thessaloniki,between August 2016 and December 2017.Forty-six patients were randomized to either the desflurane treatment group for pharmacological preconditioning(by replacement of propofol with desflurane,administered 30 min before induction of ischemia)or the control group for standard intravenous propofol.The primary endpoint of expression levels of matrix metalloproteinases and their inhibitors was determined preoperatively and at 30 min posthepatic reperfusion.The secondary endpoints of neutrophil infiltration,coagulation profile,activity of antithrombin III(AT III),protein C(PC),protein S and biochemical markers of liver function were determined for 5 d postoperatively and compared between the groups.RESULTS The desflurane treatment group showed significantly increased levels of tissue inhibitor of metalloproteinases 1 and 2,significantly decreased levels of matrix metalloproteinases 2 and 9,decreased neutrophil infiltration,and less profound changes in the coagulation profile.During the 5-d postoperative period,all patients showed significantly decreased activity of AT III,PC and protein S(vs baseline values,P<0.05).The activity of AT III and PC differed significantly between the two groups from postoperative day 1 to postoperative day 5(P<0.05),showing a moderate drop in activity of AT III and PC in the desflurane treatment group and a dramatic drop in the control group.Compared to the control group,the desflurane treatment group also had significantly lower international normalized ratio values on all postoperative days(P<0.005)and lower serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase values on postoperative days 2 and 3(P<0.05).Total length of stay was significantly less in the desflurane group(P=0.009).CONCLUSION Desflurane preconditioning can lessen the inflammatory response related to ischemia-reperfusion injury and may shorten length of hospitalization. | Eleni Koraki Ioannis Mantzoros Christos Chatzakis Anna Gkiouliava Angeliki Cheva Athina Lavrentieva Freideriki Sifaki Helena Argiriadou Isaak Kesisoglou Konstantinos Galanos-Demiris Stefanos Bitsianis Konstantinos Tsalis | 2020 | World Journal of Hepatology2020，12，11： | 4 |
| 2 | Symbolic model checking for real-time systems显示文摘 | Henzinger T A Nicollin X Sifakis J | 1994 | Journal of Information and Computation1994，111，2： | 1 |
| 3 | Geoepidemiology and space–time analysis of Primary biliary cirrhosis in Crete, Greece显示文摘 | M Koulentaki A Mantaka D Sifaki‐Pistolla E Thalassinos N Tzanakis E Kouroumalis | 2014 | Liver Int2014，，7： | 1 |
| 4 | Anemia in pregnancy 显示文摘 | Sifakis S Pharmakides G | 2000 | Ann New York Acad Sci2000，900，1： | 1 |
| 5 | Rigorous implementation of real-time systems-from theory to application 显示文摘 | Abdellatif Tesnim Combaz Jacques Sifakis Joseph | 2013 | Mathematical Structures in Computer Science2013，23，4： | 1 |
| 6 | Immune aspects and myo- metrial actions of progesterone and CRH in labor 显示文摘 | Vmclmis N Malamas FM Sifakis S | 2012 | Clin Dev Im- munol2012，2012，93： | 1 |
| 7 | Maternal serum human placental growth hormone at 11 to 13 weeks in trisomy 21 and trisomy 18 pregnancies显示文摘 | Sifakis S Akolekar R Syngelaki A | | 0，，： | 1 |
| 8 | Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus显示文摘 | Vrachnis N Belitsos P Sifakis S | | 0，，： | 1 |
| 9 | VEGF,FGF2,TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix 显示文摘 | Soufla G Sifakis S Baritaki S et at | 2005 | Cancer Lett2005，221，1： | 1 |
| 10 | Model checking: algo- rithmic verification and debugging显示文摘 | Clarke E M Emerson E A Sifakis J | 2009 | Communications of ACM2009，52，11： | 1 |
| 11 | DNA methylation in the human placenta and fetal growth (Review)显示文摘 | Ourania Koukoura Stavros Sifakis Demetrios Spandidos | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 12 | Detection of herpes simplex virus (HSV) in aborted material using the polymerase chain reaction technique显示文摘 | Sifakis S Koumantakis E Koffa M | 1998 | Gynecol-obstet-invest1998，45，2： | 1 |
| 13 | Contraception during perim- enopause 显示文摘 | Kailas NA Sifakis S Koumantakis E | 2005 | European J of Contraception and Reproductive Heahhcare2005，10，1： | 1 |
| 14 | Creating and simulating skeletal muscle from the visible human data set显示文摘 | TERAN J SIFAKIS E BLEMER S | | 0，，03： | 1 |
| 15 | Intraabdominal umbilical dilatation and term delivery, a case report and review of the literature 显示文摘 | MANTAS N SIFAKIS S KOUKOURA O | 2007 | Fetal Diagn Ther2007，22，6： | 1 |
| 16 | Decreased placental expression of hPGH,IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction显示文摘 | Koutsaki M Sifakis S Zaravinos A | | 0，，01： | 1 |
| 17 | DNA methylation in thehuman placenta and fetal growth (review)显示文摘 | Koukoura O Sifakis S Spandidos DA | 2012 | Mol Med Rep2012，5，4： | 1 |
| 18 | Elevated risk for HIV infection a- mong men who have sex with men in low-and middle-income countries 2000 - 2006 : A systematic review显示文摘 | Baral S Sifakis F Cleghorn F | 2007 | PLoS Med2007，4，： | 1 |
| 19 | Automatic determination of facial muscle activations from sparse motion capture marker data显示文摘 | SIFAKIS E NNEEROV I FEDKIW R | 2005 | ACM Trans on Graphics2005，24，3： | 1 |
| 20 | Cytokine Levels in Seminal Plasm a显示文摘 | Matalliotakis I Sifakis S Goumemou A | 1998 | Clin Exp Obstet Gynecol1998，25，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员