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| 1 | Endocrine disruptors and estrogenic effects on male reproductive axis显示文摘内分泌的 disrupt ors (例如, polychlorinated 联本基[印刷电路板] , dichlorodiphenyl-trichloroethane [DDT ] ,戴奥辛,和一些杀虫剂) 是像雌激素的并且在环境的 anti-androgenic 化学药品。他们模仿自然荷尔蒙,禁止荷尔蒙的行动,或改变内分泌系统的正常规章的功能并且有引起不孕的男繁殖的轴上的潜在的危险效果。尽管阴囊并且前列腺癌症,反常性开发,波形的 scended 睾丸,慢性炎, Sertoli-cell-only,模式,尿道下裂,改变的垂体和甲状腺腺函数也被观察,可得到的数据是不够的推出世界范围的结论。intra 细胞质的精子注射(ICSI ) 的发展在疑问以外是在男不孕的治疗的最重要的最近的突破,但是它未必确实对待原因并且可以无意中传递不利基因后果。在生理学,生物化学,和雄性生殖系统的分子、细胞的生物学的许多控制得好的临床的研究和基本科学发现在人的更大的数字的鉴定帮助了解决男因素问题。为 Y 染色体删除的察觉的更新的工具进一步加强了处于男繁殖健康和富饶的衰落可能与在环境的某些有毒的化学药品的存在有关的假设。因此,男因素不孕的病原学,诊断,和治疗仍然是真实挑战。临床医生们应该总是试图识别可能的阴囊的毒性的病原学,估计风险的度到为不孕被评估的病人,并且开始一个计划一旦在职业 / 有毒物和不孕之间的一个协会被建立了,控制并且阻止到其它的暴露。 | Suresh C. Sikka Run Wang | 2008 | Asian Journal of Andrology2008，10，1： | 12 |
| 2 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 3 | Seminal characteristics and sexual behavior in men of different age groups: is there an aging effect?显示文摘瞄准:估计精液的特征以及各种各样的年龄组的人的性行为在那些特征上建立变老的效果的存在。方法:精液样品从人被收集(n = 792 ) 仅仅在女因素不孕的情况下经历在试管内授精或子宫内的授精。样品在交际用一台精液的收集设备被收集并且根据世界卫生组织手工地评估了() 标准。人们根据他们的年龄被划分成四个组:(i) 20-30,(i i ) 31-40,(iii ) 41-50 并且(iv ) 到一张性行为问询表的 51-60 年,和他们的精液的特征和回答被比较。结果:数据统计上在测试的精液的特征显示出有效差量最尤其是在精子集中,活动性,活动性的等级,低亚硫酸钠渗透的胀大和正常精子形态学。而且,当使用严格的标准时,在有年龄的正常精子形态学的衰落是更显著的而非标准。也在全部的精子计数有差别,总计能动精子并且总计功能的精子部分(估计了由并且严格的标准) 。有效差量也以他们一直在试试到 conceive,性频率和性满足的年的数字在老人在性行为范型被观察。结论:数据当他们变老,清楚地在人在精液特征和性行为上说明变老的效果。当在构画出由的平淡的精液分析为精液特征建议正常的标准值时,变老的效果被考虑,这被建议标准。 | Panayiotis M. Zavos Khalied Kaskar Juan R. Correa Suresh C. Sikka | 2006 | Asian Journal of Andrology2006，8，3： | 10 |
| 4 | Current updates on laboratory techniques for the diagnosis of male reproductive failure显示文摘导致不孕的男繁殖失败的发生,是否由于推迟的做家长,环境问题,基因因素,药,等等,在全世界正在增加。男 subfertility 的诊断和预后成为了挑战。当基本精液评价被执行许多年了时,很多研究询问传统的精液特征的价值。这是部分由于不适当的方法和标准化,为优秀保证的技术要求的有限知识,和一个精液评价能提供临床的信息的不完全的理解。当前执行精液和内分泌的评价表演伟人可变性的实验室。世界健康组织() 精液的评估的手册是在许多年在这个领域的进一步的开发帮助了的 andrology 和生育力评估的核心。这些包括精液,对精子计数的评价,活动性,活力,形态学,和精子和精液样品的功能的方面的物理外观。这些测试也由于氧化应力包括男内分泌的侧面,精液的生物化学的评估,在浆液的 antisperm 抗体的察觉,电脑辅助的精子分析(房屋) 的使用,精子 DNA 正直,和它的损坏。帮助繁殖技术(例如, IVF, ICSI ) 显示出大成功,但是是太昂贵的。与更新的技术在这块地里推进开发,广泛的火车 / 说明能改进精确性和还原剂可变性,因此维持如此的评估的质量和标准。有迫切需要标准化了训练中心并且为繁殖成功在 mens 健康的这个区域增加了了解。 | Suresh C Sikka Wayne JG Hellstrom | 2016 | Asian Journal of Andrology2016，18，3： | 9 |
| 5 | Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen显示文摘According to the World Health Organization(WHO),oxidative stress(OS)is a significant contributor to male infertility.SeminalOS can be measured by a number of assays,all of which are either costly or time sensitive and/or require large semen volume andcomplex instrumentation.One less expensive alternative is to quantify the oxidation-reduction potential(ORP)with the MiOXSYS.In this international multi-center study,we assessed whether ORP levels measured by the MiOXSYS could distinguish semensamples that fall within the 2010 WHO normal reference values from those that do not.Semen samples were collected from 2092patients in 9 countries;ORP was normalized to sperm concentration(mV/10^6 sperm/ml).Only those samples with a concentration>1×10^6 sperm ml1 were in eluded.The results showed that 199 samples fell within the WHO no rmal refere nee range while theremaining 1893 samples did not meet one or more of the criteria.ORP was negatively correlated with all semen parameters(P <0.01)except volume.The area under the curve for ORP was 0.765.The ORP cut-off value(1.34 mV/10^6 sperm/ml)was able todifferentiate specimens with abnormal semen parameters with 98.1%sensitivity,40.6%specificity,94.7%positive predictivevalue(PPV)and 66.6%negative predictive value(NPV).When used as an adjunct to traditional semen analysis,ORP levels mayhelp identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners ofcouples sufferi ng recurre nt pregna ncy loss,and thereby directi ng these men to relevant medical therapies and lifestyle modificati ons. | Ashok Agarwal Manesh Kumar Panner Selvam Mohamed Arafa Hiroshi Okada Sheryl Homa Aideen Killeen Basak Balaban Ramadan Saleh Abdullah Armagan Shubhadeep Roychoudhury Suresh Sikka | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 6 | Effects of Acute Treatment With Tamsulosin Versus Alfuzosin on Ejaculatory Function in Normal Volunteers显示文摘 | Wayne J.G. Hellstrom Suresh C. Sikka | 2006 | The Journal of Urology2006，，4： | 2 |
| 7 | Effect of feeding spent coffee grounds on the feedlot performance and carcass quality of fattening pigs显示文摘 | Sikka S S Chawla J S | 1986 | Agricultural Wastes1986，18，4： | 1 |
| 8 | A ful1y automated Algorithm under modified FCM framework for improved Brain MR image segmentation显示文摘 | Sikka K Sinha N Singh P K eta1 | 2009 | Magnetic Resonance Imaging2009，27，7： | 1 |
| 9 | Increasing alpha angle is predictive of athletic-related〝hip〞and〝groin〞pain in collegiate National Football League prospects显示文摘 | Larson CM Sikka RS Sardelli MC | 2013 | Arthroscopy2013，29，3： | 1 |
| 10 | Bilateral variation in the origin and course of the vertebral artery显示文摘 | Sikka A Jain A | | 0，，： | 1 |
| 11 | Role of oxidative stress and antioxidants in andrology and assisted reproductive technology显示文摘 | Sikka SC | 2004 | J Androl2004，25，1： | 1 |
| 12 | Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility显示文摘 | Wang X Sharma RK Sikka S | 2003 | Fertil Steril2003，80，3： | 1 |
| 13 | Murinestrain differences and the effects of zinc on cadmiumconcentrations in tissues after acute cadmium exposure显示文摘 | King L M Anderson M B Sikka S C | 1998 | Arch Toxicol1998，72，10： | 1 |
| 14 | Nikel and iron aluminides:an overview on properties,processing,and applications显示文摘 | Deevi S C Sikka V K | 1996 | Intermetallics1996，，4： | 1 |
| 15 | Anti-icing superhydrophobic coatings 显示文摘 | CAO L L JONES A K SIKKA V K et aI | 2009 | Langmuir2009，25，12： | 1 |
| 16 | Are 1-2 tablets dangerous? Beta-blocker exposure in toddlers 显示文摘 | Love JN Sikka N | 2004 | J Emerg Med2004，26，3： | 1 |
| 17 | High-contrast imaging (FICE) improves visualization of gastrointestinal vascular ectasias显示文摘 | Ringold DA Sikka S Banerjee B | 2008 | Endoscopy2008，402，： | 1 |
| 18 | Reactive spraying of nickel-aluminide coatingd显示文摘 | Sikka V K | 1997 | Journal of Thermal Technology1997，6，3： | 1 |
| 19 | Ad- vances in processing of Ni3Al-based intermetallics and applica- tions 显示文摘 | Sikka V K Deevi S C Viswanathan S | 2000 | Intermetallics2000，8，： | 1 |
| 20 | Relative impact of oxidative stress on male reproductive function 显示文摘 | Sikka SC | 2001 | Curr MedChem2001，8，： | 1 |
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