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| 1 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding显示文摘在 2002-2003 的 SARS 的全球爆发被新人的 coronavirus SARS-CoV 的感染引起。SARS-CoV 的感染主要通过病毒的表面 glycoproteins 被调停,它由 S1 和 S2 子单元组成并且在 virions 的信封上形成更整齐的尖铁。这里,我们报导处于单个粒子的 cryo 电子显微镜学决定的不同 conformational 状态更整齐的 SARS-CoV 表面尖铁的 ectodomain 结构。1 在 4.3 点决定了的符合构造?分辨率是三方面的对称并且有所有三受体绑定 C 终端域 1 (CTD1s ) S1 子单元在在位置下面。绑定下面到 SARS-CoV 受体 ACE2 的 CTD1s 不由于位的碰撞是可能的,建议 1 代表的符合构造受体绑定不活跃的状态。在 7.3, 5.7 和 6.8 点坚定的符合构造 2-4?决定都是不对称的,在哪个 RBD 旋转离开下面由不同角度到的位置一起来位置。起来 CTD1 为 ACE2 约会暴露受体绑定地点,建议符合构造 2-4 代表受体绑定活跃状态。这个 conformational 变化也为抵销指向 CTD1 的抗体的 SARS-CoV 的绑定被要求。这现象能被扩大到为受体绑定利用 S1 子单元的 CTD1 的另外的 betacoronaviruses,它提供新卓见进在感染期间更整齐的 coronavirus 熔化前尖铁的中间的状态。 | Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang | 2017 | Cell Research2017，27，1： | 25 |
| 2 | Alpha-2-macroglobulin as a radioprotective agent: a review显示文摘Radiation is an important modality in cancer treatment, and eighty percent of cancer patients need radiotherapy at some point during their clinical management. However, radiation-induced damage to normal tissues restricts the therapeutic doses of radiation that can be delivered to tumours and thereby limits the effectiveness of the treatment. The use of radioprotectors represents an obvious strategy to obtain better tumour control using a higher dose in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical efficacy owing to their inherent toxicity and high cost. Hence, the development of radioprotective agents with lower toxicity and an extended window of protection has attracted a great deal of attention, and the identification of alternative agents that are less toxic and highly effective is an absolute necessity. Recent studies have shown that alpha-2-macroglobulin(α2M) possesses radioprotective effects. α2M is a tetrameric, disulfide-rich plasma glycoprotein that functions as a nonselective inhibitor of different types of non-specific proteases and as a carrier of cytokines, growth factors, and hormones. α2M induces protein factors whose interplay underlies radioprotection, which supports the idea that α2M is the central effector of natural radioprotection in the rat. Pretreatment with α2M has also induced a significant reduction of irradiation-induced DNA damage and the complete restoration of liver and body weight. Mihailovi? et al. concluded that the radioprotection provided by α2M was in part mediated through cytoprotection of new blood cells produced in the bone marrow; these authors also indicated that an important aspect of the radioprotective effect of amifostine was the result of the induction of the endogenous cytoprotective capability of α2M. The radioprotective effects of α2M are possibly due to antioxidant, antifibrosis, and anti-inflammatory functions, as well as the maintenance of homeostasis, and enhancement of the DNA repair and cell recovery processes. This review is the first to summarise the observations and elucidate the possible mechanisms responsible for the beneficial effects of α2M. The lacunae in the existing knowledge and directions for future research are also addressed. | Xueying Chen Xiangbo Kong Zhaoqiang Zhang Wei Chen Jieyu Chen Huanyang Li Wanting Cao Yaping Ge Silian Fang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 7 |
| 3 | Effect of Cooling Rate and Vanadium Content on the Microstructure and Hardness of Medium Carbon Forging Steel显示文摘This paper reports the effect of cooling rate on the microstructure and hardness of a kind of medium carbon steel microalloyed with two levels of V content(0.15%and 0.28%)after hot deformation by using single compression tests on a Gleeble-3800 thermal simulator.The results show that cooling rate has a significant effect on the microstructure and hardness of the tested steels.Both the fraction of pearlite and hardness increase with increasing cooling rate,whereas a further increase of the cooling rate above a critical value promotes the formation of acicular ferrite(AF),and thus leads to a decrease of hardness mainly owing to the decrease of pearlite fraction and replacing it by AF and the less effective precipitation strengthening.Increasing V content results in a significant increase of hardness,and this tendency enhances with increasing cooling rate until the formation of AF.Furthermore,increasing V content also significantly enhances the formation of AF structure at a lower cooling rate.The results also suggest that by controlling microstructure,especially the precipitation of fine V(C,N)particles through adjusting postforging cooling,the strengthening and gradient function in one hot-forging part could be obtained. | Weijun Hui Yongjian Zhang Chengwei Shao Silian Chen Xiaoli Zhao Han Dong | 2016 | Journal of Materials Science & Technology2016，32，6： | 7 |
| 4 | Nonfragile guaranteed cost control for Delta operator-formulated uncertain time-delay systems显示文摘With consideration that the controller parameters may vary from the designed value when the controller is realized, based on Lyapunov stability theory, a design method of nonfragile guaranteed cost control for a class of Delta operator-formulated uncertain time-delay systems is studied. A sufficient condition for the existence of the nonfragile guaranteed cost controller is given. A numeric example is then given to illustrate the effectiveness and the feasibility of the designed method. The results show that even if the parameters of the designed controller are of variations, the closed-loop system is still asymptotically stable and the super value of the cost function can also be obtained, while the closed-loop system will be unstable if the variations of the controller parameters are not considered when the controller is designed. The nonfragile guaranteed cost controller derived from the traditional shift operator method may cause the closed-loop system to be unstable, while the nonfragile guaranteed cost controller based on Delta operator method can avoid the unstable problem of the closed-loop system. | Ruiquan LIN, Silian CHEN, Xuwei DING (College of Electrical Engineering and Automation, Fuzhou University, Fuzhou Fujian 350108, China) | 2010 | 控制理论与应用(英文版)2010，8，2： | 2 |
| 5 | Technology innovations on high quality special steel products显示文摘Because special steels are the basic materials for industrialization,a national R&D program on special steel technology for high quality products have been granted to promote the special steel production and applications since 2008.Since then,great progresses have been achieved on ferritic stainless steel sheets,heat resistance steel pipes and tubes,microalloyed forging steel bars,and mould steel forgings for hot working. The ratio of ferritic stainless steel sheets produced by TISCO and Baosteel has been promoted through technology innovations and increased 42%and 48 in 2009 respectively.439M steel sheets have been used to exhaust system,and 444 steel sheets have been applied to kitchen and architecture.The production technologies for heat resistance steel pipes and tubes(T/P92,S3043,S31042 steels) have been developed in Baosteel and Pansteel to meet the market requirements.Meanwhile,the round bloom technology has been initiated in Xingcheng Steel.The new technologies for microalloyed forging steels,low cost steel bar,and tailored steel and components,were proposed by CISRI based on the understanding of precise chemical composition and segregation control.And the applications of microalloyed forging steel bars have been promoted remarkably.The researchers have developed high quality mould steel technologies,heavy section forgings of 718 steel,high premium H13 steel blocks and large diameter mandrels used for seamless pipe rolling.The technology innovations of the program could lead to the progress of production technology in special steel sheets,pipes,bars and forgings,and meet the demands from market.For the moment,it is actually believed that there still strong requirements for the technology innovations on special steels. | DONG Han~(1)),CHEN Silian~(1)),LAN Denian~(2)) and LIU Zhongdong~(1)) 1) Central Iron & Steel Research Institute,Beijing 100081,China 2) Chinese Iron & Steel Association,Beijing 100711,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 6 | Development of modified PMMA cement in spine surgery显示文摘1.Background.Polymethyl methacrylate(PMMA)bone cement has been widely used in orthopedic clinics for over 70 years.In 1952 and 1953,Kiaer and Haboush reported their work on the use of PMMA cement to achieve bone adherence to prostheses in femoral head replacement[1,2],.In 1987,Galibert et al.first reported the use of PMMA cement in spinal surgery for vertebroplasty(PVP)to treat vertebral hemangiomas[3].By 2002,approximately 38,000 vertebroplasties and 16,000 kyphoplasties were performed in the United States[4]. | Zhikun Li Junwei Shi Yi Wang Yifan Li Wenjun Liu Ruijun Xu Silian Wang Liwei Chen Xiaojian Ye Chi Zhang Wei Xu | 2023 | Engineered Regeneration2023，4，4： | 0 |
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