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| 1 | Variable-step integration method for milling chatter stability prediction with multiple delays显示文摘This paper analyzes the stability of milling with variable pitch cutter and tool runout cases characterized by multiple delays,and proposes a new variable-step numerical integration method for efficient and accurate stability prediction. The variable-step technique is emphasized here to expand the numerical integration method,especially for the low radial immersion cases with multiple delays. First,the calculation accuracy of the numerical integration method is discussed and the variable-step algorithm is developed for milling stability prediction for single-delay and multiple-delay cases,respectively. The milling stability with variable pitch cutter is analyzed and the result is compared with those predicted with the frequency domain method and the improved full-discretization method. The influence of the runout effect on the stability boundary is investigated by the presented method. The numerical simulation shows that the cutter runout effect increases the stability boundary,and the increasing stability limit is verified by the milling chatter experimental results in the previous research. The numerical and experiment results verify the validity of the proposed method. | ZHANG XiaoJian XIONG CaiHua DING Ye XIONG YouLun | 2011 | Science China(Technological Sciences)2011，54，12： | 17 |
| 2 | Milling stability analysis using the spectral method显示文摘This paper focuses on the development of an efficient semi-analytical solution of chatter stability in milling based on the spectral method for integral equations. The time-periodic dynamics of the milling process taking the regenerative effect into account is formulated as a delayed differential equation with time-periodic coefficients,and then reformulated as a form of integral equation. On the basis of one tooth period being divided into a series of subintervals,the barycentric Lagrange interpolation polynomials are employed to approximate the state term and the delay term in the integral equation,respectively,while the Gaussian quadrature method is utilized to approximate the integral term. Thereafter,the Floquet transition matrix within the tooth period is constructed to predict the chatter stability according to Floquet theory. Experimental-validated one-degree-of-freedom and two-degree-of-freedom milling examples are used to verify the proposed algorithm,and compared with existing algorithms,it has the advantages of high rate of convergence and high computational efficiency. | DING Ye ZHU LiMin ZHANG XiaoJian DING Han | 2011 | Science China(Technological Sciences)2011，54，12： | 11 |
| 3 | Response Sensitivity Analysis of the Dynamic Milling Process Based on the Numerical Integration Method显示文摘As one of the bases of gradient-based optimization algorithms, sensitivity analysis is usually required to calculate the derivatives of the system response with respect to the machining parameters. The most widely used approaches for sensitivity analysis are based on time-consuming numerical methods, such as finite difference methods. This paper presents a semi-analytical method for calculation of the sensitivity of the stability boundary in milling. After transforming the delay-differential equation with time-periodic coefficients governing the dynamic milling process into the integral form, the Floquet transition matrix is constructed by using the numerical integration method. Then, the analytical expressions of derivatives of the Floquet transition matrix with respect to the machining parameters are obtained. Thereafter, the classical analytical expression of the sensitivity of matrix eigenvalues is employed to calculate the sensitivity of the stability lobe diagram. The two-degree-of-freedom milling example illustrates the accuracy and efficiency of the proposed method. Compared with the existing methods, the unique merit of the proposed method is that it can be used for analytically computing the sensitivity of the stability boundary in milling, without employing any finite difference methods. Therefore, the high accuracy and high efficiency are both achieved. The proposed method can serve as an effective tool for machining parameter optimization and uncertainty analysis in high-speed milling. | DING Ye ZHU Limin ZHANG Xiaojian DING Han | 2012 | Chinese Journal of Mechanical Engineering2012，25，5： | 4 |
| 4 | A new approach to dissecting complex traits by combining quantitative trait transcript (QTT) mapping and diallel cross analysis显示文摘A promising way to uncover the genetic architectures underlying complex traits may lie in the ability to recognize the genetic variants and expression transcripts that are responsible for the traits' inheritance.However,statistical methods capable of investigating the association between the inheritance of a quantitative trait and expression transcripts are still limited.In this study,we described a two-step approach that we developed to evaluate the contribution of expression transcripts to the inheritance of a complex trait.First,a mixed linear model approach was applied to detect significant trait-associated differentially expressed transcripts.Then,conditional analysis were used to predict the contribution of the differentially expressed genes to a target trait.Diallel cross data of cotton was used to test the application of the approach.We proposed that the detected differentially expressed transcripts with a strong impact on the target trait could be used as intermediates for screening lines to improve the traits in plant and animal breeding programs.It can benefit the discovery of the genetic mechanisms underlying complex traits. | YANG DaiGang YE ChengYin MA XiongFeng ZHU ZhiHong ZHOU XiaoJian WANG HaiFeng MENG QingQin PEI XiaoYu YU ShuXun ZHU Jun | 2012 | Chinese Science Bulletin2012，57，21： | 3 |
| 5 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 6 | Second-order full-discretization method for milling stability prediction显示文摘 | Ye Ding LiMin Zhu XiaoJian Zhang Han Ding | 2010 | International Journal of Machine Tools and Manufacture2010，，10： | 1 |
| 7 | A full- discretization method for prediction of milling stability 显示文摘 | Ding Ye Zhu Limin Zhang Xiaojian | 2010 | International Journal of Machine Tools & Manu- facture2010，50，： | 1 |
| 8 | Nu- merical Integration Method for Prediction of Milling Stability显示文摘 | Ding Ye Zhu Limin Zhang Xiaojian | 2011 | Journal of Manufacturing Science and Engineering Transactions of the ASME2011，133，3： | 1 |
| 9 | A fulldiscretization method for prediction of milling stability显示文摘 | DING Ye ZHU Limin ZHANG Xiaojian | 2010 | International Journal of Machine Tools and Manufacture2010，50，5： | 1 |
| 10 | Biphasic calcium phosphate nano-composite scaffolds reinforced with bioglass provide a synthetic alternative to autografts in a canine tibiofibula defect model显示文摘 | Tang Dezhi Xu Guohua Yang Zhou Holz Jonathan Ye Xiaojian Cai Shu Yuan Wen Wang Yongjun | 2014 | Chinese Medical Journal2014，，7： | 1 |
| 11 | A full-discretization method for prediction of milling stability显示文摘 | Ye Ding LiMin Zhu XiaoJian Zhang Han Ding | 2010 | International Journal of Machine Tools and Manufacture2010，，5： | 1 |
| 12 | Anatomy-related risk factors in Harm's mesh subsidence in cervical reconstruction after one-level corpectomy显示文摘Objective:To clarify anatomy-related factors in the cervical spine with subsidence of titanium mesh cage (TMC) after one-level cervical corpectomy and fusion. The effect of the cervical posture, segmental curvature and endplate gradient on this postoperative phenomenon was evaluated. Methods: Between August 2003 and March 2006, a total of the 236 patients underwent one-level corpectomy and TMC fusion. Their radiological examinations were reviewed and clinical outcomes evaluated. Results: In the patients who were followed up for 12 months, TMC subsidence occurred in 54 (28.6%) cases. C6 corpectomy had a significant higher risk (26/60, 43.3%) for TMC subsidence, which was correlated with the variation of the gradient of the vertebral endplates against cervical levels. Although the clinical outcome was comparable with those in the literature, the patients may have subsidence-related problems such as neck-shoulder pain, neurological deterioration and instrumental failure. Conclusion: To decrease the incidence of subsidence, TMC design should be optimized to be in line with anatomic characteristics of the cervical spine. | Wu Jianxin Ye Xiaojian | 2009 | Journal of Medical Colleges of PLA(China)2009，24，4： | 1 |
| 13 | Syringomyelia after operation:diagnosis and its formational mechanism显示文摘描述 MRI 调查结果并且在脊骨以后在病人讨论 syringomyelia 的致病形成机制的目的外科的操作。完全, 13 个病人在学习被注册的方法。在手术前,任何一个都没与针的绳索 syringomyelia 我们的病人介绍。吝啬的后续持续时间由 MRI 是 6 年(范围 210 月) 。在针的绳索肿瘤以后的 13 个病人中的四个移开操作,在针的损伤操作以后的 3 个病人, 2 个盒子以前有脊柱侧凸, 2 个盒子是颈的 spondylotic myelopathy, 2 个盒子以前拴住绳索症候群操作。操作前的先生特征并且在所有病人上操作以后与外科的结果和临床的症状在对比被学习。辐射学诊断被 3 个不同放射线学者分别地做。长度,宽度,信号,洞的形状以及 subarachnoid 形状的特征上被集中。结果所有病人以前没在 MRI 上有 syringomyelia 手术。7 个病人的针的绳索出现了坚持压缩和 2 个病人以前拴住绳索操作。在在我们的情况中的操作以后的 syringomyelia 的 MRI 特征证明有鸣管液体的纵的洞有脑髓的液体(CSF ) 的 T1 和 T2 关系特征。吝啬的长度是 5.5 针的片断, 13 个病人的 4 绳索介绍了从前面的材料压缩的绳索, 4 发生了对腰部的针的运河和 1 格的针的绳索的背的手术后的粘附依附颈的针的运河的前面墙。在在针的外科的干预以后的病人的 syringomyelia 的机制可以是在操作前的时期的针的绳索的坚持的压缩或意愿的结论或操作以后。浮肿,包囊,针的绳索的 malacia 是最重要的损害,风险因素导致 syringomyelia。 | Shi Jiangang Jia Lianshun Yuan Wen Shi Guodong Wu Jianfeng Ye XiaoJian Ni Bin Xiao Jianru Tan Junming Xu Guohua | 2008 | Journal of Medical Colleges of PLA(China)2008，23，2： | 1 |
| 14 | A full-dis- cretization method for prediction of milling stability 显示文摘 | DING YE ZHU LIMIN ZHANG XIAOJIAN | 2010 | Interna- tional Journal of Machine Tools and Manufacture2010，50，5： | 1 |
| 15 | A mesoporous silica nanoparticulate/ β -TCP/BG composite drug delivery system for osteoarticular tuberculosis therapy显示文摘 | Min Zhu Huixue Wang Jiyong Liu Hailong He Xuguo Hua Qianjun He Lingxia Zhang Xiaojian Ye Jianlin Shi | 2010 | Biomaterials2010，，7： | 1 |
| 16 | A full-discretization method for prediction of milling stability显示文摘 | Ye Ding LiMin Zhu XiaoJian Zhang Han Ding | 2010 | International Journal of Machine Tools and Manufacture2010，，5： | 1 |
| 17 | pH-responsive delivery of H_(2) through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization显示文摘Imbalance of oxidative and inflammatory regulation is themain contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury(SCI).As an emerging biosafe strategy for protecting against oxidative and inflammatory damage,hydrogen(H_(2))therapy is a promising approach for improving the microenvironment to allow neural regeneration.However,achieving release of H_(2) at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H_(2).Thus,we assembled SiO_(2)@mSiO_(2) mesoporous silica nanoparticles and loaded them with ammonia borane(AB),which has abundant capacity and allows controllable release of H_(2) in an acid-dependent manner.The release of H_(2) from AB/SiO_(2)@mSiO_(2) was satisfactory at pH 6.6,which is approximately equal to the microenvironmental acidity after SCI.After AB/SiO_(2)@mSiO_(2) were intrathecally administered to ratmodels of SCI,continuous release of H_(2) fromthese nanoparticles synergistically enhanced neurofunctional recovery,reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction.Furthermore,in the subacute phase of SCI,microglia were markedly polarized toward the M2 phenotype by H_(2) via inhibition of TLR9 expression in astrocytes.In conclusion,H_(2) delivery through AB/SiO_(2)@mSiO_(2) has the potential to efficiently treat SCI through comprehensivemodulation of the oxidative and inflammatory imbalance in themicroenvironment. | Yi Liu Yeying Wang Bing Xiao Guoke Tang Jiangming Yu Weiheng Wang Guohua Xu Xiaojian Ye | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 18 | Development of modified PMMA cement in spine surgery显示文摘1.Background.Polymethyl methacrylate(PMMA)bone cement has been widely used in orthopedic clinics for over 70 years.In 1952 and 1953,Kiaer and Haboush reported their work on the use of PMMA cement to achieve bone adherence to prostheses in femoral head replacement[1,2],.In 1987,Galibert et al.first reported the use of PMMA cement in spinal surgery for vertebroplasty(PVP)to treat vertebral hemangiomas[3].By 2002,approximately 38,000 vertebroplasties and 16,000 kyphoplasties were performed in the United States[4]. | Zhikun Li Junwei Shi Yi Wang Yifan Li Wenjun Liu Ruijun Xu Silian Wang Liwei Chen Xiaojian Ye Chi Zhang Wei Xu | 2023 | Engineered Regeneration2023，4，4： | 0 |
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