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| 1 | Diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, particularly in parts of the developing world, and is increasing in incidence. This article reviews the current modalities employed for the diagnosis of HCC, including serum markers, radiological techniques and histological evaluation, and summarises international guidelines for the diagnostic approach to HCC. | Asmaa I Gomaa Shahid A Khan Edward LS Leen Imam Waked Simon D Taylor-Robinson | 2009 | World Journal of Gastroenterology2009，15，11： | 44 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 4 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 5 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 6 | Determination of organophlsphorus pesticide residues in Cilento( Campania, Italy)virgin olive oil by capillary gas chromatography 显示文摘 | I RASTRELLI L TOTARO K SIMONE F D | 2002 | Food Chemistry2002，79，： | 1 |
| 7 | B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression显示文摘 | Simon 1 Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 8 | Magnet Levitation at Your Fingertips显示文摘 | Geim A K Simon M D Boamfa M I | | 0，，6742： | 1 |
| 9 | B7-H4 is overexpressed in early-stage ovarian cancer and is independent of CAl25 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 10 | Fluorescence detec- tion to determine proteins and humic-like substances fingerprints of exopolymeric substances(EPS) from biological sludges per- formed by size exclusion chromatography(SEC)显示文摘 | BHATIA D BOURVEN I SIMON S | 2013 | Bioresource Technology2013，131，： | 1 |
| 11 | Magnet levitation on your fingertips显示文摘 | GEIM A K SIMON M D BOAMFA M I | 1999 | Nature1999，400，： | 1 |
| 12 | B7-H4 is over-expressed in earlystage ovarian cancer and is independent of CA125 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais l | 2007 | Gynecol (hacol2007，106，2： | 1 |
| 13 | Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia显示文摘 | Idanpaan-Heikkila I Simon PM Zopf D | 1997 | J Inject Dis1997，176，3： | 1 |
| 14 | Mutations in the maternally im- printed gene MKRN3 are common in familial central precocious pu- berty显示文摘 | Simon D Ba I Mekhail N | 2016 | Enr J Endocrinol2016，174，1： | 1 |
| 15 | Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells 显示文摘 | Sukhova G K Shi G P Simon D I | 1998 | J Clin Invest1998，102，3： | 1 |
| 16 | B7-H4 is over- expressed in early-stage ovarian cancer and is independent of CA125 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 17 | Potential of rapeseed meal as an alternative protein source in complete diets for tilapia (Oreochromis mossambi- cus Peters) 显示文摘 | Simon J D Stuart M C Robert I B | 1990 | Aquaculture1990，87，2： | 1 |
| 18 | Platelet glycoprotein Ibα is a counterreceptor for the leukocyte integrin Mac-1(CD11b/CD18) 显示文摘 | SIMON D I CHEN Z XU M | 2000 | J Exp Med2000，192，2： | 1 |
| 19 | NO forms an adduct with serum albumin that has endothelium-derived relaxing factorlike properties显示文摘 | Keaney J F Jr Simon D I Stamler J S | 1993 | J Clin Invest1993，91，4： | 1 |
| 20 | Exciton simulations of optical spectra of the FMO complex from the green sulfur bacterium chlorobium tepidum at 6k 显示文摘 | Simone I E Michiel A D Robert J W | 1998 | J Plays Chem B1998，102，： | 1 |
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