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| 1 | The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors显示文摘 | Wei Gong Kun He Mike Covington S. R Dinesh-Kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga | 2008 | Molecular Plant2008，1，1： | 7 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Genomic era diagnosis and management of hereditary and sporadic colon cancer显示文摘The morbidity and mortality attributable to heritable and sporadic carcinomas of the colon are substantial and affect children and adults alike. Despite current colonoscopy screening recommendations colorectal adenocarcinoma(CRC) still accounts for almost 140000 cancer cases yearly. Familial adenomatous polyposis(FAP) is a colon cancer predisposition due to alterations in the adenomatous polyposis coli gene, which is mutated in most CRC. Since the beginning of the genomic era next-generation sequencing analyses of CRC continue to improve our understanding of the genetics of tumorigenesis and promise to expand our ability to identify and treat this disease. Advances in genome sequence analysis have facilitated the molecular diagnosis of individuals with FAP, which enables initiation of appropriate monitoring and timely intervention. Genome sequencing also has potential clinical impact for individuals with sporadic forms of CRC, providing means for molecular diagnosis of CRC tumor type, data guiding selection of tumor targeted therapies, and pharmacogenomic profiles specifying patient specific drug tolerances. There is even a potential role for genomic sequencing in surveillance for recurrence, and early de-tection, of CRC. We review strategies for diagnostic assessment and management of FAP and sporadic CRC in the current genomic era, with emphasis on the current, and potential for future, impact of genome sequencing on the clinical care of these conditions. | Edward David Esplin Michael Paul Snyder | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 5 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 6 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 2 |
| 7 | High-throughput sequencing for biology and medicine显示文摘 | Wendy Weijia Soon Manoj Hariharan Michael P Snyder | 2013 | Molecular Systems Biology2013，22，1： | 1 |
| 8 | Synthesis and biological evaluation of c-aminophosphonates as potent, subtype-selectivesphingosine 1-phosphate receptor qagonists and antagonists 显示文摘 | Frank W Foss Jr Ashley H Snyder Michael D Davis | 2007 | Bioorg Med Chem2007，15，2： | 1 |
| 9 | Prospective Multicenter Study of a Synthetic Bioabsorbable Anal Fistula Plug to Treat Cryptoglandular Transsphincteric Anal Fistulas显示文摘 | Michael J. Stamos Michael Snyder Bruce W. Robb Alex Ky Marc Singer David B. Stewart Toyooki Sonoda Herand Abcarian | 2015 | Diseases of the Colon & Rectum2015，，3： | 1 |
| 10 | A positive psychology field ofdreams:“If you build it,they will come”显示文摘 | Snyder C D Michael M | 2000 | Journal of Socialand Clinical Psychology2000，，1： | 1 |
| 11 | Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase显示文摘 | Seyun Kim Sangwon F. Kim David Maag Micah J. Maxwell Adam C. Resnick Krishna R. Juluri Anutosh Chakraborty Michael A. Koldobskiy Seung Hun Cha Roxanne Barrow Adele M. Snowman Solomon H. Snyder | 2011 | Cell Metabolism2011，，2： | 1 |
| 12 | Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma显示文摘 | Stephen D. W. Beck MD Manish I. Patel MD Mark E. Snyder BA Michael W. Kattan MD Robert J. Motzer MD Victor E. Reuter MD Paul Russo MD | 2004 | Annals of Surgical Oncology2004，，1： | 1 |
| 13 | Maturation-Dependent Acquired Coronary Structural Alterations and Atherogenesis in the Dahl Sodium-Sensitive Hypertensive Rat显示文摘 | Charles R. Kiefer James B. McKenney Jane F. Trainor L. Michael Snyder | 2002 | Circulation: Journal of the American Heart Association2002，，19： | 1 |
| 14 | IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 显示文摘 | Michael G Bird Helmut Greim Robert Snyder | 1982 | International Agency for Research on Cancer1982，，29： | 1 |
| 15 | Applying circulating tumor DNA methylation in the diagnosis of lung cancer显示文摘Lung cancer is the leading cause of cancer-related deaths worldwide.Low dose computed tomography(LDCT)is commonly used for disease screening,with identified candidate cancerous regions further diagnosed using tissue biopsy.However,existing techniques are all invasive and unavoidably cause multiple complications.In contrast,liquid biopsy is a noninvasive,ideal surrogate for tissue biopsy that can identify circulating tumor DNA(ctDNA)containing tumorigenic signatures.It has been successfully implemented to assist treatment decisions and disease outcome prediction.ctDNA methylation,a type of lipid biopsy that profiles critical epigenetic alterations occurring during carcinogenesis,has gained increasing attention.Indeed,aberrant ctDNA methylation occurs at early stages in lung malignancy and therefore can be used as an alternative for the early diagnosis of lung cancer.In this review,we give a brief synopsis of the biological basis and detecting techniques of ctDNA methylation.We then summarize the latest progress in use of ctDNA methylation as a diagnosis biomarker.Lastly,we discuss the major issues that limit application of ctDNA methylation in the clinic,and propose possible solutions to enhance its usage. | Lei Li Kai Fu Wenyu Zhou Michael Snyder | 2019 | Precision Clinical Medicine2019，2，1： | 1 |
| 16 | Third nerve palsy following carotid artery dissection and posterior cerebral artery thrombectomy: Case report and review of the literature显示文摘 | Michael Kogan Sabareesh Natarajan Nina Kim Robert Sawyer Kenneth Snyder Adnan Siddiqui | 2014 | Surgical Neurology International2014，，15： | 1 |
| 17 | Protein chip technology显示文摘 | Heng Zhu Michael Snyder | 2003 | Current Opinoin in Chemical Biology2003，7，： | 1 |
| 18 | Hope Therapy in a Community Sample: A Pilot Investigation显示文摘 | Jennifer S. Cheavens David B. Feldman Amber Gum Scott T. Michael C. R. Snyder | 2006 | Social Indicators Research2006，，1： | 1 |
| 19 | Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes显示文摘 | Gary A. Herman Arthur Bergman Catherine Stevens Paul Kotey Bingming Yi Peng Zhao Bruno Dietrich George Golor Andreas Schrodter Bart Keymeulen Kenneth C. Lasseter Mark S. Kipnes Karen Snyder Deborah Hilliard Michael Tanen Caroline Cilissen Marina De Smet I | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，11： | 1 |
| 20 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 1 |
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