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| 1 | Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells显示文摘Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a concern.However,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue regeneration.Herein,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications. | Soyoun Um Jueun Ha Soo Jin Choi Wonil Oh Hye Jin Jin | 2020 | World Journal of Stem Cells2020，12，12： | 4 |
| 2 | TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells显示文摘Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation.Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells(DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed. Currently, little is known about the relationship between the inflammatory environment and bone formation. Osteogenic differentiation of inflamed DFSCs resulted in decreased alkaline phosphatase(ALP) activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. Protein profile analysis via liquid chromatography coupled with tandem mass spectrometry was performed to analyse the differences in protein expression in inflamed and normal tissue. Comparison of inflamed and normal DFSCs showed significant changes in the level of expression of transforming growth factor(TGF)-β2. Porphyromonas gingivalis(P.g.)-derived lipopolysaccharide(LPS) was used to create in vitro inflammatory conditions similar to periodontitis. The osteogenic differentiation of LPS-treated DFSCs was suppressed, and the cells displayed low levels of TGF-β1 and high levels of TGF-β2. DFSCs treated with TGF-β2 inhibitors showed significant increases in alizarin red S staining and ALP activity. TGF-β1 expression was also increased after inhibition of TGF-β2. By examining inflamed DFSCs and LPS-triggered DFSCs, these studies showed both clinically and experimentally that the increase in TGF-β2 levels that occurs under inflammatory conditions inhibits bone formation. | Soyoun Um Joo-Hee Lee Byoung-Moo Seo | 2018 | International Journal of Oral Science2018，10，4： | 4 |
| 3 | Structural health management technologies for inflatable/deployable structures: Integrating sensing and self-healing显示文摘 | Erik J. Brandon Max Vozoff Elizabeth A. Kolawa George F. Studor Frankel Lyons Michael W. Keller Brett Beiermann Scott R. White Nancy R. Sottos Mark A. Curry David L. Banks Robert Brocato Lisong Zhou Soyoun Jung Thomas N. Jackson Kevin Champaigne | 2010 | Acta Astronautica2010，，7： | 1 |
| 4 | Sport Participation Across National Contexts: A Multilevel Investigation of Individual and Systemic Influences on Adult Sport Participation显示文摘 | SoYoun Lim Stacey Warner Marlene Dixon Brennan Berg Chiyoung Kim Michael Newhouse-Bailey | 2011 | European Sport Management Quarterly2011，，3： | 1 |
| 5 | An efficient differential evolution using speeded-up k-nearest neighbor estimator显示文摘 | Park Soyoun Lee Jujang | 2014 | Soft Computing2014，18，1： | 1 |
| 6 | Inflammatory cytokine induction by siRNAs is cell type- and transfection reagent-specific显示文摘 | Jae Wook Yoo Sun Woo Hong Soyoun Kim Dong-ki Lee | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 7 | Simultaneous suppression of three genes related to brassinosteroid (BR) biosynthesis altered campesterol and BR contents, and led to a dwarf phenotype in Arabidopsis thaliana显示文摘 | Ho Yong Chung Shozo Fujioka Sunghwa Choe Soyoun Lee Youn Hyung Lee Nam In Baek In Sik Chung | 2010 | Plant Cell Reports2010，，4： | 1 |
| 8 | Numerical and Experimental Study on Droplet Spreading Motion after Impingement Considering Dynamic Contact Angle with CCUP (CIP-Combined Unified Procedure) Method显示文摘 | Soyoun Son Gwonhyun Ko Hongsun Ryou | 2013 | Journal of Energy and Power Engineering2013，7，1： | 0 |
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