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| 1 | Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells显示文摘Pancreatic cancer(PC) is the most aggressive type of common cancers, and in 2014, nearly 40000 patients died from the disease in the United States. Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is characterized by an intense stromal desmoplastic reaction surrounding the cancer cells. Cancer-associated fibroblasts(CAFs) are the main effector cells in the desmoplastic reaction, and pancreatic stellate cells are the most important source of CAFs. However, other important components of the PC stroma are inflammatory cells and endothelial cells. The aim of this review is to describe the complex interplay between PC cells and the cellular and noncellular components of the tumour stroma. Published data have indicated that the desmoplastic stroma protects PC cells against chemotherapy and radiation therapy and that it might promote the proliferation and migration of PC cells. However, in animal studies, experimental depletion of the desmoplastic stroma and CAFs has led to more aggressive cancers. Hence, the precise role of the tumour stroma in PC remains to be elucidated. However, it is likely that a contextdependent therapeutic modification, rather than pure depletion, of the PC stroma holds potential for the development of new treatment strategies for PC patients. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2016 | World Journal of Gastroenterology2016，22，9： | 20 |
| 2 | Multiple Calcium-Dependent Kinases Modulate ABA-Activated Guard Cell Anion Channels显示文摘 | Sonke Scherzer Tobias Maierhofer Khaled A.S. Al-Rasheid Dietmar Geiger Rainer Hedrich | 2012 | Molecular Plant2012，5，6： | 7 |
| 3 | Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations显示文摘AIM To determine whether it is possible to identify different immune phenotypic subpopulations of cancer-associated fibroblasts (CAFs) in pancreatic cancer (PC). METHODS We defined four different stromal compartments in surgical specimens with PC: The juxtatumoural, peripheral, lobular and septal stroma. Tissue microarrays were produced containing all pre-defined PC compartments, and the expression of 37 fibroblast (FB) and 8 extracellular matrix (ECM) markers was evaluated by immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization. The compartment-specific mean labelling score was determined for each marker using a four-tiered scoring system. DOG1 gene expression was examined byquantitative reverse transcription PCR (qPCR). RESULTS CD10, CD271, cytoglobin, DOG1, miR-21, nestin, and tenascin C exhibited significant differences in expression profiles between the juxtatumoural and peripheral compartments. The expression of CD10, cytoglobin, DOG1, nestin, and miR-21 was moderate/strong in juxtatumoural CAFs (j-CAFs) and barely perceptible/weak in peripheral CAFs (p-CAFs). The upregulation of DOG1 gene expression in PC compared to normal pancreas was verified by qPCR. Tenascin C expression was strong in the juxtatumoural ECM and barely perceptible/weak in the peripheral ECM. CD271 expression was barely perceptible in j-CAFs but moderate in the other compartments. Galectin-1 was stronger expressed in j-CAFs vs septal fibroblasts, PDGFRβ, tissue transglutaminase 2, and hyaluronic acid were stronger expressed in lobular fibroblasts vs p-CAFs, and plectin-1 was stronger expressed in j-CAFs vs l-FBs. The expression of the remaining 33 markers did not differ significantly when related to the quantity of CAFs/FBs or the amount of ECM in the respective compartments.CONCLUSION Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. Future studies should determine whether CAF subpopulations have different functional properties. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 4 | Effects of diurnal temperature range on adult size and emergence times from diapausing pupae in Papilio glaucus and R canadensis (Papilionidae)显示文摘与温暖趋势的最近的气候,两热变化的增加(即,日报温度范围;数据终端就绪) 象增加的平均数一样,温度可以影响许多不同有机体,特别变温动物的无脊椎动物。昆虫的预言用户外每日平均温度之单位的发展的率(在发展的底上面的热单位累积昆虫的阀值) 基于每天吝啬的温度,不管数据终端就绪。然而,在工具和极端的非线性和变化经常被忽略。热变化的角色(例如,每日的温度极端和数据终端就绪) 用 18 的一个普通天 / 夜里光周期为二燕子尾巴蝴蝶姐妹种试验性地被评估:6 h 相片:scoto 阶段和相应白天 thermophase 和 22 的夜间 cryophase 时期:22al 反射 Fourier 变换 infr 瓘 ? 瓘?? | J. Mark Scriber Brittany Sonke | 2011 | Insect Science2011，18，4： | 2 |
| 5 | Using RGB displays to portray colorrealistic imagery to animal eyes显示文摘RGB displays effectively simulate millions of colors in the eyes of humans by modulating the rela-tive amount of light emitted by 3 differently colored juxtaposed lights (red, green, and blue). Therelationship between the ratio of red, green, and blue light and the perceptual experience of thatlight has been well defined by psychophysical experiments in humans, but is unknown in animals.The perceptual experience of an animal looking at an RGB display of imagery designed for humansis likely to poorly represent an animal's experience of the same stimulus in the real world. This isdue, in part, to the fact that many animals have different numbers of photoreceptor classes thanhumans do and that their photoreceptor classes have peak sensitivities centered over differentparts of the ultraviolet and visible spectrum. However, it is sometimes possible to generate videosthat accurately mimic natural stimuli in the eyes of another animal, even if that animal's sensitivityextends into the ultraviolet portion of the spectrum. How independently each RGB phosphor stimu-lates each of an animal's photoreceptor classes determines the range of colors that can be simu-lated for that animal. What is required to determine optimal color rendering for another animal is adevice capable of measuring absolute or relative quanta of light across the portion of the spectrumvisible to the animal (i.e., a spectrometer), and data on the spectral sensitivities of the animal'sphotoreceptor classes. In this article, we outline how to use such equipment and information togenerate video stimuli that mimic, as closely as possible, an animal's color perceptual experienceof real-world objects. | Cynthia TEDORE Sonke JOHNSEN | 2017 | Current Zoology2017，63，1： | 2 |
| 6 | Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager显示文摘 | Ploeger LS Brand B | 2004 | Med Phy2004，31，2： | 1 |
| 7 | Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients;first clinical results and comparison with elect ronic portal-imaging device显示文摘 | Borst GR Sonke JJ Betgen A | 2007 | Int J Radiat Oncology Biol Phys2007，68，2： | 1 |
| 8 | Methylmercury photodegradation influenced by sea-ice cover in arctic marine eco- systems显示文摘 | Point D Sonke J E Day R D | 2011 | Nature Geoscience2011，4，3： | 1 |
| 9 | Breast patient setup error assessment:comparison of electronic portal image devices and cone-beam computed tomography matching results显示文摘 | TOPOLNJAK R SONKE J J NUKAMP J | 2010 | Int J Radiat Oncol Biol Phys2010，78，4： | 1 |
| 10 | Mercury isotope fractionation during liquid-vapor evaporation experiments 显示文摘 | Estrade N Carignan J Sonke J E | 2009 | Geochimica et Cosmochimica Acta2009，73，10： | 1 |
| 11 | Analysis of K- ras mutation in pancreatic tissue after fine needle aspirates 显示文摘 | Brigitte P Sonke A Ken B | 1999 | Anticancer Res1999，19，10： | 1 |
| 12 | A novel method for megavoltage scatter correction in cone-beam CT acquired concurrent with rotational irradiation显示文摘 | van Herk M Ploeger L Sonke JJ | 2011 | Radiother Oncol2011，100，13： | 1 |
| 13 | Variability of four - di- mensional computed tomography patibnt models 显示文摘 | Sonke J J Lebesque J van Herk M | 2008 | Int J Radiat Oncoi Biol Phys2008，70，5： | 1 |
| 14 | Kilo - voltage cone - beam computed tomography setup measurements for lung cancer patients : first clinical results and comparison with electronic portal -imaging device 显示文摘 | Borst G R Sonke J J Betgen A | 2007 | Int J Radiat Oncol Biol Phys2007，68，2： | 1 |
| 15 | Kilo-voltage cone-beam com- puted tomography set-up measurements for lung cancer patients: First clinical results and comparison with electronic portal- imaging device显示文摘 | Borst GR Sonke JJ Betgen A | 2007 | Int J Radiat Oncol Biol Phys2007，68，2： | 1 |
| 16 | Mid- ventila- tion CT scan construction from four - dimensional respira- tion - correlated CT scans for radiotherapy planning of lung cancer patients 显示文摘 | Wolthaus JWR Seluxeider C Sonke JJ | 2006 | Int J Radiat Oncol Biol Phys2006，65，23： | 1 |
| 17 | Prediction of bladder outlet obstruction in men with lower urinary tract symptoms using artificial neural networks显示文摘 | SONKE G S HESKES T VERBEEK A L | 2000 | J Urol2000，163，1： | 1 |
| 18 | Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients;first clinical results and comparison with electronic portal-imaging de-vice显示文摘 | Borst GR Sonke JJ Betqen A | 2007 | Int J Radiat Oncol Biol Phys2007，68，2： | 1 |
| 19 | Clinical and therapeutic aspects of extrapulmonary small cell carcinoma显示文摘 | Walenkamp AM Sonke GS Sleijfer DT | | 0，，03： | 1 |
| 20 | A novel method for megavoltage scatter correction in cone-beam CT acquired concurrent with rotational irradiation 显示文摘 | VAN HERK M PLOEGER L SONKE J J | 2011 | Radiother Oncol2011，100，3： | 1 |
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