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| 1 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 2 | Stereosolective esterification of dl-menthol by polyurethane-entrapped lipase in organic solvent显示文摘 | Keshiro S Sonomoto K Tanaka A | | 0，，01： | 1 |
| 3 | Recent advances in lactic acid production by microbial fermentation processes 显示文摘 | Abdel-Rahman MA Tashiro Y Sonomoto K | 2013 | Biotechnology Advances2013，31，6： | 1 |
| 4 | Diseontinuation of etanercept in patients with rheumatoid arthritis who were in clinical remission 显示文摘 | Miyamura T Sonomoto K Nakamura M | 2010 | Clin Rheumatol2010，29，： | 1 |
| 5 | Class 11a bacteriocins: biosynthesis, structure and activity显示文摘 | ENNAHAR S SASHIHARA T SONOMOTO K | 2000 | FEMS Microbiology Reviews2000，24，1： | 1 |
| 6 | Lantibiotic nisin Z fermentative production by Lactococcus lactis IO-l: relationship between production of the lantibiotic and lactate and cell growth显示文摘 | MATSUSAKI H ENDO N SONOMOTO K | 1996 | Applied Microbiology Biotechnology1996，45，1： | 1 |
| 7 | Monitoring of the multiple bacteriocin production by Enterococcus faecium NKR-5-3 through a developed liquid chromatography and mass spectrometry-based quantification system显示文摘 | Rodney H. Perez Kohei Himeno Naoki Ishibashi Yoshimitsu Masuda Takeshi Zendo Koji Fujita Pongtep Wilaipun Vichien Leelawatcharamas Jiro Nakayama Kenji Sonomoto | 2012 | Journal of Bioscience and Bioengineering2012，，5： | 1 |
| 8 | Novel bacteriocins from lactic acid bacteria (LAB) : various structures and ap-plications显示文摘 | PEREZ R H ZENDO T SONOMOTO K | 2014 | Microb Cell Fact2014，13，1： | 1 |
| 9 | Recent advances in lactic acid production by microbial fermentation processes显示文摘 | Mohamed Ali Abdel-Rahman Yukihiro Tashiro Kenji Sonomoto | 2013 | Biotechnology Advances2013，，： | 1 |
| 10 | Lactic acidproduction from lignocellulose derived sugars using lacticacid bacteria overview and limits显示文摘 | Abdel-Rahmana M A Yukihiro T Sonomoto K | 2011 | Journal of Biotechnolo-gy2011，156，4： | 1 |
| 11 | Immobilized biocatalysts in organic solvents 显示文摘 | Sonomoto K | 1990 | Chem Tech1990，20，： | 1 |
| 12 | Class IIa bacteriocins: biosynthesis, structure and activity显示文摘 | ENNAHAR S SASHIHARA T SONOMOTO K | 2000 | Microbiology Reviews2000，24，1： | 1 |
| 13 | Biosynthetic production of nisin Z by immobilized Lactococcus lactis显示文摘 | K Sonomoto N Chinachoti N Endo | 2000 | Journal of Molecular Catalysis B:Enzymatic2000，10，： | 1 |
| 14 | Kinetic study on△1-Dehydrogenation of Hydrocortisone by Gel-Entrapped Arthrobacter simplex cells 显示文摘 | SONOMOTO K MATSUNO R TANAKA A | 1984 | J Ferment Technol1984，62，2： | 1 |
| 15 | Lactic acid production from lignocellulose-derived sugars using lactic acid bacteria:overview and limits显示文摘 | Abdel-Rahman M A Tashiro Y Sonomoto K | 2011 | Journal of Biotechnology2011，156，4： | 1 |
| 16 | Interleukin-1beta induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway显示文摘 | Sonomoto K Yamaoka K Oshita K | 2012 | Arthritis Rheum2012，64，10： | 1 |
| 17 | Peptide - lipidhuge toroidal pore, a new antimicrobial mechanismmediated by a lac- tococcal bacteriocin, lacticin Q 显示文摘 | Yoneyama F hnura Y Sonomoto K | 2009 | Anti- microbial Agents and Chemotherapy2009，53，8： | 1 |
| 18 | Class IIa bacteriocins from lactic acid bacteria: Antibacterial activity and food preservation显示文摘 | Ennahar S Sonomoto K Ishizaki A | 1999 | Journal of Bioscience and Bioengineer- ing1999，87，6： | 1 |
| 19 | Recent advances in lactic acid production by microbial fermentation processes 显示文摘 | Abdel-Rahman M A Tashiro Y Sonomoto K | 2013 | Biotechnology Advances2013，31，6： | 1 |
| 20 | Fermentative production of lactic acid from renewable materials:Recent achievements,prospects,and limits显示文摘 | Wang Y Tashiro Y Sonomoto K | 2015 | Journal of Bioscience and Bioengineering2015，119，1： | 1 |
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