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| 1 | An herbal formula,CGX,exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats显示文摘AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats. METHODS: Liver injuries were induced in Wistar rats by injection of DMN (ip, 10 mg/mL per kg) for 3 consecutive days per week for 4 wk. The rats were administered with CGX (po, 100 or 200 mg/kg per day) or distilled water as a control daily for 4 wk starting from the 15th d of the DMN treatment. Biochemical parameters (serum albumin, bilirubin, ALP, AST and ALT), lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-b, TIMP-1, TIMP-2, PDGF-b, and MMP-2, all of which are known to be associated with liver fibrosis, were analyzed using real-time PCR. RESULTS: CGX administration restored the spleen weight to normal after having been increased by DMN treatment. Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP (P < 0.05), ALT (P < 0.01), and AST (P < 0.01) that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly up-regulated expression of TNF-α, TGF-b, TIMP-1, TIMP-2, PDGF-b, and MMP-2. Of these, the gene expression encoding PDGF-b and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration. CONCLUSION: CGX exhibits hepatotherapeutic proper- ties against chronic hepatocellular destruction and consequential liver fibrosis. | Jang-Woo Shin Jin-Young Son Se-Mi Oh Seung-Hyun Han Jing-Hua Wang Jung-Hyo Cho Chong-Kwan Cho Hwa-Seung Yoo Yeon-Weol Lee Myong-Min Lee Xiao Ping Hu Chang-Gue Son | 2006 | World Journal of Gastroenterology2006，12，38： | 5 |
| 2 | 经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识显示文摘近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。 | Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES | 2019 | Gastroenterology Report2019，7，1： | 3 |
| 3 | Approaching 18%efficiency of ternary organic photovoltaics with wide bandgap polymer donor and well compatible Y6:Y6-1O as acceptor显示文摘A series of ternary organic photovoltaics(OPVs)are fabricated with one wide bandgap polymer D18-Cl as donor,and well compatible Y6 and Y6-1O as acceptor.The open-circuit-voltage(V_(OC))of ternary OPVs is monotonously increased along with the incorporation of Y6-1O,indicating that the alloy state should be formed between Y6 and Y6-1O due to their excellent compatibility.The energy loss can be minimized by incorporating Y6-1 O,leading to the V_(OC)improvement of ternary OPVs.By finely adjusting the Y6-1O content,a power conversion efficiency of 17.91%is achieved in the optimal ternary OPVs with 30 wt%Y6-1O in acceptors,resulting from synchronously improved short-circuit-current density(JSC)of 25.87 mA cm^(-2),fill factor(FF)of 76.92%and V_(OC)of 0.900 V in comparison with those of D18-Cl:Y6 binary OPVs.The JSC and FF improvement of ternary OPVs should be ascribed to comprehensively optimal photon harvesting,exciton dissociation and charge transport in ternary active layers.The more efficient charge separation and transport process in ternary active layers can be confirmed by the magnetophotocurrent and impedance spectroscopy experimental results,respectively.This work provides new insight into constructing highly efficient ternary OPVs with well compatible Y6 and its derivative as acceptor. | Xiaoling Ma Anping Zeng Jinhua Gao Zhenghao Hu Chunyu Xu Jae Hoon Son Sang Young Jeong Caixia Zhang Mengyang Li Kai Wang He Yan Zaifei Ma Yongsheng Wang Han Young Woo Fujun Zhang | 2021 | National Science Review2021，8，8： | 3 |
| 4 | Significance of vulnerability assessment in establishment of Hainan provincal disaster medical system显示文摘Hainan is an island province in south China with a high frequency of unconventional emergencies due to its special geographic location and national military defense role.Given the limited transportation route from Hainan to the outside world,self-rescue is more important to Hainan Province than other provinces in China and it is therefore imperative to establish an independent, scientific as well as efficient provincal disaster medical system in Hainan.The regulatory role for vulnerability analysis/assessment has been demonstrated in establisment of disaster medical system in varoius countries and or regions.In this paper,we attempt to describe/propose how to adopt vulnerability assessment through mathematical modeling of major biophysical social vulnerability factors to establish an independent,scientific,effieicnt and comprehensive provincial disaster medical system in Hainan. | Min Li Chuanzhu Lu Wei Son Junhong Miao Yipeng Ding Longhe Li Leilei Zhang Nin Zhao Bijiang Hu Yunjun Zhang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 2 |
| 5 | TALL-1 is a novel member of the TNF family that is down-regulated by mitogens显示文摘 | Shu HB Hu WH John son H | 1999 | J Leukoc Biol1999，65，5： | 1 |
| 6 | Strong convergence of approximated sequences for asymptotically nonexpansive mappings in Banach spaces显示文摘 | | 2004 | Axta Math Scientic2004，24，2： | 1 |
| 7 | Carcinoma of the gallbladder: autopsy findings in 287 cases and review of the literature显示文摘 | Sons HU Brcharnd F Joel BS | 1985 | J Surg Oncol1985，28，： | 1 |
| 8 | A derivative of L-allo threonine alleviates 2, 4-dinitrofluorobenzene-induced atopic dermatitis indications 显示文摘 | Heo JC Son HU Kim SL | 2012 | Biosci Biotechnol Biochem2012，76，11： | 1 |
| 9 | Rosiglitazone activates renal sodium-and water-reabsorptive pathways and lower blood pressure in normal rats显示文摘 | Sons J Knepper MA Hu X | 2004 | J Pharmacol Exp Ther2004，308，2： | 1 |
| 10 | Epicardial fat cell size,fat distribution and fat infiltration of the right and left ventricle of the heart显示文摘 | Sons HU Hoffmann V | | 0，，： | 1 |
| 11 | A derivative of L-allo threonine alle- viates 2,4-dinitrofluorobenzene-induced atopic dermatitis indications 显示文摘 | Heo JC Son HU Kim SL | 2012 | Biosci Biotechnol Biochem2012，76，11： | 1 |
| 12 | Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice显示文摘 | Xiao-Ping Hu Jang-Woo Shin Jing-Hua Wang Jung-Hyo Cho Jin-Young Son Chong-Kwan Cho Chang-Gue Son | 2008 | Journal of Ethnopharmacology2008，，1： | 1 |
| 13 | Resistance to Brand Switching When a Radically New Brand Is Introduced:A Social Identity Theory Perspective显示文摘 | Son K Lam Michael Ahearne Ye Hu Niels Schillewaert | 2010 | Joumal of Marketing2010，，11： | 1 |
| 14 | Esophageal cancer:Autopsy findings in 171 cases显示文摘 | Sons Hu Brouchard F | 1984 | Arch Pathol Lab Med1984，108，： | 1 |
| 15 | Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes显示文摘 | Hu L Kim TM Son MY | 2013 | Na- ture2013，501，7468： | 1 |
| 16 | A de- rivative of L-allo threonine alleviates 2, 4- dinitrofluorobenzene-induced atopic der- matitis indications 显示文摘 | Heo JC Son HU Kim SL | 2012 | Biosci Biotechnol Biochem2012，76，11： | 1 |
| 17 | Transcriptomic study of the red palm weevil Rhynchophorus ferrugineus embryogenesis显示文摘红手掌象鼻虫(RPW ) , Rhynchophorus ferrugineus (翘目:Curculionidae ) ,一侵略,隐藏并且破坏织物 borer,和它成为植物的手掌家庭的一个致命的害虫并且被报导了在地球附近攻击 20 手掌种类。在我们越过 RPW embryogenesis 的五个发展阶段分析 transcriptomes 的地方,这里,我们在 RPW 的 embryogenesis 上报导系统的 transcriptomic 研究,包含四个胚胎的阶段(E1, E2, E3 和 E4 ) 和一个幼虫的阶段(L1 ) 。用 RNA-seq 和下一代的平台,我们产生了 80 到 91million 为每个图书馆读并且装配在不同胚胎的阶段被表示的 22532 基因。在从五个胚胎的发展阶段的全部的抄本之中,我们发现 30.45% 是表示的差别, 10.10 % 表演阶段特性甚至更大的部分, 62.88% ,在所有阶段展出组成的表示。我们也分析几条保存发信号的小径的表示动力学(例如刺猬, JAK-STAT,槽口, TGF-β , Ras/MAPK 和 Wnt ) ,以及关键发展基因,与 apoptosis,轴形成, Hox 建筑群,神经发生和分割有关包括那些。数据集为基因注解和 RPW 功能的 genomics 提供一个必要资源,包括由使用从多重学科的工具和概念的研究,例如开发,生理学,生物化学,分子的生物学和遗传。 | An Yin Linlin Pan Xiaowei Zhang Lei Wang Yuxin Yin Shangang Jia Wanfei Liu Chengqi Xin Kan Liu Xiaoguang Yu Gaoyuan Sun Khalid AI-hudaib Son qnian Hu Ibrahim S. AI-Mssallem Jun Yu | 2015 | Insect Science2015，22，1： | 0 |
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