|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013，19，23： | 14 |
| 2 | Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine显示文摘Hepatitis B virus(HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new infections and its devastating consequences. The vaccine is administered intramuscularly in three doses, with 95% showing long lasting serologic immunity. An additional fourth dose or a repeated higher dose three course regimen is given to those that fail to show immunity. Despite these additional regimens, some remain vulnerable to hepatitis B and are deemed nonresponders. Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of non-response. Various strategies have been developed to elicit an immune response in these individuals. These include increased vaccination dose, intradermal administration, alternative adjuvants, alternative routes of administration, co-administration with other vaccines, and other novel therapies. These alternative strategies can show improved response and lasting immunity. In summary, HBV vaccination is a major advance of modern medicine and all individuals at risk should be sought and vaccinated with subsequent adequate titers demonstrated. | Saqib Walayat Zohair Ahmed Daniel Martin Srinivas Puli Michael Cashman Sonu Dhillon | 2015 | World Journal of Hepatology2015，7，24： | 12 |
| 3 | Attenuation of Collagen Induced Arthritis by Centella asiatica Methanol Fraction via Modulation of Cytokines and Oxidative Stress显示文摘Objective To investigate the anti-inflammatory, antioxidant and anti-arthritic effects of Centella asiatica methanolfraction(CaM E) on collagen-induced arthritis(CIA), an animal model of rheumatoid arthritis. Methods Arthritis was induced in female wistar rats by immunization with porcine type II collagen. The CIA rats were treated orally with CaM E(50, 150, and 250 mg/kg/day) for 15 d(beginning on day 21 of the experimental period). The clinical, histological, biochemical, and immunological parameters were assessed. Results CaM E treatment(150 and 250 mg/kg) significantly attenuated the severity of CIA and reduced the synovial inflammation, cartilage erosion, and bone erosion as evident from both histological and radiographic data. The escalated plasma levels of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12 alongwith nitric oxide in CIA rats decreased significantly on CaM E treatment. The serum levels of type-II collagen antibody were significantly lower in rats of CaM E(150 and 250 mg/kg) treated group than those in the arthritic group. Furthermore, by inhibiting the above mediators, CaM E also contributed towards the reversal of the disturbed antioxidant levels and peroxidative damage. Conclusion Our results clearly indicate that oral administration of CaM E suppresses joint inflammation, cytokine expression as well as antioxidant imbalance, thereby contributing to an amelioration of arthritis severity in CIA rats. | Shikha Sharma Ritu Gupta Sonu Chand Thaku | 2014 | Biomedical and Environmental Sciences2014，27，12： | 6 |
| 4 | Pyogenic liver abscess caused by Fusobacterium in a 21-year-old immunocompetent male显示文摘A 21-year-old male with no significant past medical history, presented with right upper quadrant(RUQ) abdominal pain along with fevers and chills. Lab work revealed leukocytosis, anemia, and slightly elevated alkaline phosphatase. Viral serology for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus were negative and he was immunocompetent.Computed tomography imaging revealed hepatic abscesses, the largest measuring 9.5 cm. Empiric antibiotics were started and percutaneous drains were placed in the abscesses. Anaerobic cultures from the abscesses grew Fusobacterium nucleatum. This is a gram negative anaerobic bacteria; a normal flora of the oral cavity. Fusobacterium is most commonly seen in Lemiere's disease, which is translocation of oral bacteria to the internal jugular vein causing a thrombophlebitis and subsequent spread of abscesses. Our patient did not have Lemiere's, and is the first case described of fusobacterium pyogenic liver abscess in a young immunocompetent male with good oral hygiene. This case was complicated by sepsis, empyema, and subsequent abscesses located outside the liver. These abscesses' have the propensity to flare abruptly and can be fatal. This case not only illustrates fusobacterium as a rare entity for pyogenic liver abscess, but also the need for urgent diagnosis and treatment. It is incumbent on physicians to diagnose and drain any suspicious hepatic lesions. While uncommon, such infections may develop without any overt source and can progress rapidly. Prompt drainage with antibiotic therapy remains the cornerstone of therapy. | Zohair Ahmed Saurabh K Bansal Sonu Dhillon | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 5 | Bile cast nephropathy: A case report and review of the literature显示文摘Bile cast nephropathy is a condition of renal dysfunction in the setting of hyperbilirubinemia. There are very few cases of this condition reported in the last decade and a lack of established treatment guidelines. While the exact etiology remains unknown, bile cast nephropathy is presumed to be secondary to multiple concurrent insults to the kidney including direct toxicity from bile acids, obstructive physiology from bile casts, and systemic hypoperfusion from vasodilation. Therapy directed at bilirubin reduction may improve renal function, but will likely need dialysis or plasmapheresis as well. We report our case of bile cast nephropathy and the therapeutic measures undertaken in a middle-aged male with chronic renal insufficiency that developed hyperbilirubinemia and drug-induced liver injury secondary to antibiotic use. He developed acute renal injury in the setting of rising bilirubin. He subsequently had a progressive decline in renal and hepatic function, requiring dialysis and plasmapheresis with some improvement, ultimately requiring transplantation. | Jaymon Patel Saqib Walayat Nikhil Kalva Sidney Palmer-Hill Sonu Dhillon | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 6 | Management of polytrauma patients in emergency department:An experience of a tertiary care health institution of northern India显示文摘BACKGROUND:In a tertiary care institute of northern India,the emergency department receives an average of 6-7 patients with poly trauma every day.Of these patients,some come directly and many are referred from other hospitals from the region.Various problems are faced in the management of patients with poly trauma.This study aimed to elicit various complaints,suggestions and possible solutions in the management of patients with poly trauma.METHODS:A retrospective cross sectional study was done on 210 patients in the emergency OPD for a period of 2 months.All the records of the patients with poly trauma were studied and the problems during their management were measured against 6 predetermined steps(step Ⅰ to step Ⅵ).RESULTS:In the younger generation,males were predominantly the primary victims of poly trauma injury,and road traffic accident was the major etiological factor.Injuries involving more than2 specialties induced many problems during the management of patients with poly trauma.Of 210 patients we studied,32 patients had problems at various steps and maximum problems in step Ⅲ,i.e.co-ordination between various specialties in the management of patients with poly trauma.CONCLUSION:A proper poly trauma management team and a well defined standard operative procedure are the keys to effective management of patients with poly trauma by minimizing the problems encountered. | Puri Payal Goel Sonu Gupta Anil K Verma Prachi | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 7 | Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?显示文摘AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control population.pothesis that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic database.Outpatients from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 codes.Inclusion criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control population.Using these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma controls.Statistics were performed using corrected chisquare analysis.The primary outcome for this study was the diagnosis of PTC.Approval to conduct this study was obtained by the Institutional Review Board at the University of Pennsylvania.RESULTS:The mean age was 47.5 years(range:18-102 years) and 66% patients were female.An analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with PTC.Nine patients(0.5%) with UC were diagnosed with PTC.Patients with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma controls.Four patients(0.4%) with CD were diagnosed with PTC.Patients with CD were not shown to be more likely to develop PTC(OR:1.334,95%CI 0.485-3.672) compared to a control population with asthma.Nine patients(0.5%) with a history of diverticulitis were diagnosed with PTC.Patients with diverticulitis were not shown to be more likely to develop PTC(OR:1.673,95%CI 0.831-3.368) compared to asthma controls.Patients with CD or UC were not less likely to develop PTC compared to those with diverticulitis(CD OR:0.80,95%CI 0.25-2.60;UC OR:0.92,95%CI 0.37-2.33).None of the patients used immunosuppressant medications prior to the diagnosis of PTC(azathioprine,6-mercaptopurine,and methotrexate).CONCLUSION:There is a significant difference in age of diagnosis of PTC in patients with CD compared to patients with UC and the control populations studied. | Irene S Sonu Wojciech Blonski Ming Valerie Lin James Lewis Faten Aberra Gary R Lichtenstein | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 8 | Field observation of nearshore circulation and meandering current 显示文摘 | Sonu C J | 1972 | Journal of geophysical research1972，77，18： | 1 |
| 9 | Trends in major and minor meteorological variables and their influence on reference evapotranspiration for mid Himalayan region at east Sikkim, India显示文摘Estimation of evapotranspiration(ET) for mountain ecosystem is of absolute importance since it serves as an important component in balancing the hydrologic cycle.The present study evaluates the performance of original and location specific calibrated Hargreaves equation(HARG) with the estimates of Food and Agricultural Organization(FAO)Penman Monteith(PM) method for higher altitudes in East Sikkim,India.The results show that the uncalibrated HARG model underestimates ET_0 by 0.35 mm day^(-1) whereas the results are significantly improved by regional calibration of the model.In addition,this paper also presents the variability in the trajectory associated with the climatic variables with the changing climate in the study site.Nonparametric Mann-Kendall(MK) test was used to investigate and understand the mean monthly trendof eight climatic parameters including reference evapotranspiration(ET_0) for the period of 1985-2009.Trend of ET_0 was estimated for the calculations done by FAO PM equation.The outcomes of the trend analysis show significant increasing(p ≤ 0.05) trend represented by higher Z-values,through MK test,for net radiation(Rn),maximum temperature(Tmax) and minimum temperature(Tmin),especially in the first months of the year.Whereas,significant(0.01 ≥ p ≤0.05) decreasing trend in vapor pressure deficit(VPD)and precipitation(P) is observed throughout the year.Declining trend in sunshine duration,VPD and ET_0 is found in spring(March- May) and monsoon(June –November) season.The result displays significant(0.01≤ p ≤ 0.05) decreasing ET_0 trend between(June- December) except in July,exhibiting the positive relation with VPD followed by sunshine duration at the station.Overall,the study emphasizes the importance of trend analysis of ET_0 and other climaticvariables for efficient planning and managing the agricultural practices,in identifying the changes in the meteorological parameters and to accurately assess the hydrologic water balance of the hilly regions. | Shweta YADAV Proloy DEB Sonu KUMAR Vanita PANDEY Pankaj Kumar PANDEY | 2016 | Journal of Mountain Science2016，13，2： | 1 |
| 10 | Variations in soil microbial biomass and crop roots due to differing resource quality inputs in a tropical dryland agroecosystem显示文摘 | Sonu S Nandita G Singh K P | 2007 | Soil Biology and Biochemistry2007，39，1： | 1 |
| 11 | Field observation of nearshore circulation and meandering currents显示文摘 | Sonu C J | 1972 | Journal of Geophysical Research1972，77，18： | 1 |
| 12 | A transcriptional profile ofaging in the human kidney显示文摘 | Rodwell GE Sonu R Zahn JM Lund J | 2004 | PLOS Biology2004，2，12： | 1 |
| 13 | Solvent extraction equilibrium and modeling studies of manganese from sulfate solutions by a mixture of Cyanex 301 and TBP显示文摘 | Nagaphani Kumar Batchu Chong Ho Sonu Man Seung Lee | 2014 | Hydrometallurgy2014，，： | 1 |
| 14 | Synergistic solvent extraction of manganese(II) with a mixture of Cyanex 272 and Cyanex 301 from chloride solutions显示文摘 | Nagaphani Kumar Batchu Chong Ho Sonu Man Seung Lee | 2013 | Hydrometallurgy2013，，： | 1 |
| 15 | The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function显示文摘 | Weiming Fu Michael Killen Carsten Culmsee Sonu Dhar Tej K. Pandita Mark P. Mattson | 2000 | Journal of Molecular Neuroscience (-)2000，，1： | 1 |
| 16 | Circulating endothelial progenitor cells as potential prognostic biomarker in multiple myeloma显示文摘 | Archana Bhaskar Ritu Gupta Lalit Kumar Atul Sharma Mehar Chand Sharma Mani Kalaivani Sonu Chand Thakur | 2012 | Leukemia & Lymphoma2012，，4： | 1 |
| 17 | Altered Telomere Nuclear Matrix Interactions and Nucleosomal Periodicity in Ataxia Te-langiectasia Cells before and after Ionizing Radiation Treatment显示文摘 | Lubomir BS Sonu Dh Tej KP | 1999 | Mol Cell Biol1999，19，10： | 1 |
| 18 | Estimation of tegaserod in human plasma by high-performance liquid chromatography-tandem mass spectroscopy and its application to bioequivalence study 显示文摘 | SONU SS HARSHVARDHAN P KULDEEP S | 2006 | Anal Chim Acta2006，557，12： | 1 |
| 19 | Cell intrinsic alterations underlie hematopoietic stemcell aging 显示文摘 | Rossi DJ Bryder D Zahn JM Ahlenius H Sonu R WagersAJ | 2005 | Proceedings of the National Academy of Sciencesof the United States of America2005，102，： | 1 |
| 20 | Field observation of nearshore circulation and meandering currents显示文摘 | Sonu C J | 1972 | Journal of Geophysical Research1972，77，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员