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| 1 | Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma显示文摘BACKGROUND: Notch signaling is critical to physiologic angiogenesis and has been implicated in tumor angiogenesis and metastasis. Notch signaling was reported to exert either oncogenic or tumor-suppressive function in hepatocellular carcinoma (HCC) tumorigenesis. However, the prognostic significance of Notch receptors in HCC remains uncertain. In this study, we investigated the roles of Notch receptors in the prognosis of HCC. METHODS: We investigated the expressions of Notch receptors in tumor tissue microarrays of 288 patients with primary HCC who had undergone curative resection using immunohistochemistry. Additionally, prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 97.1 months. Tumor recurrence was detected in 189 patients (65.6%), and 99 (34.4%) died of HCC. RESULTS: Cytoplasmic expression of Notch1, cytoplasmic expression of Notch3, coexistent nuclear expression of Notch3, and cytoplasmic Notch4 overexpression were observed in 145 (50.3%), 60 (20.8%), 17 (5.9%), and 172 (59.7%) of the 288 HCCs, respectively. Multivariate analyses revealed that Notch1 expression (P=0.029), Edmondson grade Ⅲ (P=0.038), and higher BCLC stage (P<0.001) were independent predictors of shorter disease-free survival. Cytoplasmic Notch3 expression tended to be an independent predictor of shorter disease-free survival (P=0.055). Notch1 expression (P=0.039), Notch4 overexpression (P=0.012), and higher BCLC stage (P<0.001) were independent predictors of shorter disease-specific survival. On univariate analysis, Notch1 expression tended to show an unfavorable influence on disease-specific survival (P=0.063) and Notch4 overexpression did not show an unfavorable influence on disease-specific survival (P=0.103). CONCLUSIONS: Notch1 expression might be an independent predictor of both shorter disease-free survival and shorter disease-specific survival in HCC patients after curative resection. Notch4 overexpression might be an independent predictor of shorter disease-specific survival. Notch1 could be used as an immunohistochemical biomarker to detect patients with a high-risk of recurrence. Notch1 and Notch4 could be used as immunohistochemical biomarkers to detect patients with a shorter disease-specific survival. | Soomin Ahn Jiyeon Hyeon Cheol-Keun Park | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 12 |
| 2 | Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy显示文摘BACKGROUND:Progression of hepatocellular carcinoma (HCC) often leads to vascular invasion and intrahepatic metastasis,which correlate with recurrence after surgical treatment and poor prognosis.HCC may be an unusual cancer affected by continuous inflammation that can lead to consistent upregulation of transforming growth factor-β (TGF-β).Chronic inflammation shifts hepatocytic TGF-β signaling from the tumor-suppressive pSmad3C pathway to the oncogenic pSmad3L pathway.In this study,we investigated the functional roles of Smad3 and its phosphoisoforms in the progression of HCC.METHODS:Tumor tissue microarrays of samples from 272 HCC patients who underwent curative surgical resection were used to detect the expression of Smad3,Smad4,pSmad3C (S423/425),pSmad3L (T179),pSmad3L (S204),and pSmad3L (S213).Disease-specific death was defined as 1) tumor occupying more than 80% of the liver,2) portal venous tumor thrombus (PVTT) proximal to the second bifurcation,3) obstructive jaundice due to tumor,4) distant metastases,or 5) variceal hemorrhage with PVTT proximal to the first bifurcation.At the time of analysis,tumor recurrence was detected in 184 (67.6%) patients,and 96 (35.3%) had died of HCC.RESULTS:Nuclear and cytoplasmic localization of Smad3,and nuclear localization of Smad4 were observed in 18.0%,9.9%,and 9.2% of HCCs,respectively.The rates of Smad3 phosphoisoform-immunoreactive HCC varied according to the location of phosphorylation:pSmad3C (S423/425) 8.1%,pSmad3L (T179) 2.6%,pSmad3L (S204) 2.2%,and pSmad3L (S213) 10.3%.Multivariate analyses revealed that pSmad3C (S423/425) (P=0.022) was an independent predictor of longer recurrence-free survival.pSmad3L (S213) (P=0.006),intrahepatic metastasis,multicentric occurrence,and liver cirrhosis were independent predictors of shorter recurrence- free survival.Cytoplasmic Smad3 (P=0.006),larger tumor size,and intrahepatic metastasis were independent predictors of shorter disease-specific survival.Only pSmad3L (S213) did not show an unfavorable influence on recurrence-free survival (P=0.331) on univariate analysis.CONCLUSIONS:pSmad3C (S423/425),pSmad3L (S213),and Smad3 may be predictors of prognosis in HCC patients after curative hepatectomy.pSmad3C (S423/425) and pSmad3L (S213) may be used as immunohistochemical biomarkers to identify patients with a high risk of recurrence. | Seok-Hyung Kim Soomin Ahn Cheol-Keun Park | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 4 |
| 3 | Pulmonary sequestration infected with nontuberculous mycobacteria:a report of two cases and literature review显示文摘We report two cases of pulmonary sequestration infected with nontuberculous mycobacteria(NTM): Mycobacterium avium and Mycobacterium abscessus.Chest computed tomography showed pneumonic consolidation in the right lower lobe,which received a systemic blood supply from the descending aorta in both patients.Video-assisted thoracoscopic surgeries were successfully performed and pathologica]examinations revealed multiple caseating granulomas.A review of the literature revealed only seven previous case reports of pulmonary sequestration infected with NTM,and no case with Mycobacterium abscessus has been reported. | Won-Jung Koh Goohyeon Hong Kwhanmien Kim Soomin Ahn Joungho Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，11： | 2 |
| 4 | Preparation of poly ( L-lactide) microcapsules for fragrant fiber and their characteristics 显示文摘 | HONG Kijeong PARK Soomin | 2000 | Polymer2000，41，12： | 1 |
| 5 | Characterization of ovalbumin containing polyurethane microcapsules with different structures 显示文摘 | HONG Kijeong SOOMIN Park | 2000 | Polymer Testing2000，19，： | 1 |
| 6 | Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis显示文摘 | Soomin Shin Katharine A. Walz Angela S. Archambault Julia Sim Bryan P. Bollman Jessica Koenigsknecht-Talboo Anne H. Cross David M. Holtzman Gregory F. Wu | 2014 | Journal of Neuroimmunology (-)2014，，1： | 1 |
| 7 | Genome-wide discovery of DNA polymorphism in Brassica rapa显示文摘 | Soomin Park Hee-Ju Yu Jeong-Hwan Mun Seung-Chan Lee | 2010 | Molecular Genetics and Genomics2010，，2： | 1 |
| 8 | Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet显示文摘 | Soomin Cho Youngshim Choi Soyoung Park Taesun Park | 2012 | The Journal of Nutritional Biochemistry2012，，： | 1 |
| 9 | Characterization of ovalbumin-cintaining polyurethane microcapsules with different structures 显示文摘 | Kijeong Hong Soomin Park | 2000 | Polymer Testing2000，19，： | 1 |
| 10 | Expression of Fibroblast Growth Factor 19 Is Associated with Recurrence and Poor Prognosis of Hepatocellular Carcinoma显示文摘 | Jiyeon Hyeon Soomin Ahn Jae Jun Lee Dae Hyun Song Cheol-Keun Park | 2013 | Digestive Diseases and Sciences2013，，7： | 1 |
| 11 | Preparation of poly( 1-lactide)microcapsules for fragrant fiber and their characteristics 显示文摘 | Kijeong Hong Soomin Park | 2000 | Polymer2000，41，： | 1 |
| 12 | Preparation of poly (L-lactide)microcapsules fra- grant fiber and their characteristics 显示文摘 | Hong Ijeong Park Soomin | 2000 | Polymer2000，41，： | 1 |
| 13 | Preparation of Poly (L-lactide) Micro capsules Fragrant Fiber and Their Characteristics 显示文摘 | Hong I Soomin P | 2000 | Polymer2000，41，： | 1 |
| 14 | Distributed random projection algorithm for convex optimization显示文摘 | SOOMIN LEE ANGELIA N | 2013 | IEEE J Sel Topics Signal Processing2013，7，2： | 1 |
| 15 | Preparation of poly(L-lactide) microcapsules for fragrant fiber and their eharacteristics显示文摘 | Hong Kijeong Park Soomin | 2000 | Polymer2000，41，12： | 1 |
| 16 | Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes显示文摘 | Helle Linnebjerg Soomin Park Prajakti A. Kothare Michael E. Trautmann Kenneth Mace Mark Fineman Ian Wilding Michael Nauck Michael Horowitz | 2008 | Regulatory Peptides2008，，1： | 1 |
| 17 | Park Genome-wide identification of NBS encoding resistance genes in Brassica rapa显示文摘 | Jeong-Hwan Mun Hee-Ju Yu Soomin Park | 2009 | Mol Genet Genomics2009，，282： | 1 |
| 18 | A synthesis of gra- phene/Co3O4thin films for lithium ion battery an- odes by coelectrodeposition 显示文摘 | Gil-Pyo Kim Inho Nam Nam Dong Kim Junsu Park Soomin Park Jongheop Yi | 2012 | Electrochemistry Communications2012，2，2： | 1 |
| 19 | Gastrointestinal stromal tumors in children and young adults: a clinicopathologic and molecular genetic study of 22 Korean cases显示文摘 | Guhyun Kang Young Soo Park Eun‐Sun Jung Mee Joo Mi Seon Kang Soomin Ahn Gu Hyum Kang Kyoung‐Mee Kim | 2013 | APMIS2013，，10： | 1 |
| 20 | Effect of silicon-doped calcium phosphate cement on angiogenesis based on controlled macrophage polarization显示文摘Vascularization is an important early indicator of osteogenesis involving biomaterials. Bone repair and new bone formation are associated with extensive neovascularization. Silicon-based biomaterials have attracted widespread attention due to their rapid vascularization. Although calcium phosphate cement (CPC) is a mature substitute for bone, the application of CPC is limited by its slow degradation and insufficient promotion of neovascularization. Calcium silicate (CS) has been shown to stimulate vascular endothelial proliferation. Thus, CS may be added to CPC (CPC–CS) to improve the biocompatibility and neovascularization of CPC. In the early phase of bone repair (the inflammatory phase), macrophages accumulate around the biomaterial and exert both anti- and pro-inflammatory effects. However, the effect of CPC–CS on macrophage polarization is not known, and it is not clear whether the effect on neovascularization is mediated through macrophage polarization. In the present study, we explored whether silicon-mediated macrophage polarization contributes to vascularization by evaluating the CPC–CS-mediated changes in the immuno-environment under different silicate ion contents both in vivo and in vitro. We found that the silicon released from CPC–CS can promote macrophage polarization into the M2 phenotype and rapid endothelial neovascularization during bone repair. Dramatic neovascularization and osteogenesis were observed in mouse calvarial bone defects implanted with CPC–CS containing 60% CS. These findings suggest that CPC–CS is a novel biomaterial that can modulate immune response, promote endothelial proliferation, and facilitate neovascularization and osteogenesis. Thus, CPC–CS shows potential as a bone substitute material. | Soomin Lee Zheng Li Dehua Meng Qinming Fei Libo Jiang Tengfei Fu Ze Wang Shuhao Liu Jian Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
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