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| 1 | Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children显示文摘AIM:To compare intradermal(ID) and intramuscular(IM) booster doses,which have been used in healthy and high risk subjects,such as healthcare workers,haemodialysis patients,human immunodeficiency virus patients,and renal transplant recipients unresponsive to initial hepatitis B vaccination,in celiac individuals.METHODS:We conducted our study on 58 celiac patients,vaccinated in the first year of life,whose blood analysis had showed the absence of protective hepatitis B virus(HBV) antibodies.All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year.In all patients we randomly performed an HBV vaccine booster dose by ID or IM route.Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine(Engerix B) 2 g by the ID route,while 28 celiac patients were revaccinated with Engerix B 10 g by the IM route.Four weeks after every booster dose,the anti-hepatitis B surface(HBs) antibody titer was measured by an enzyme-linked immuneadsorbent assay.We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose.The cut off value for a negative anti-HBs antibody titer was 10 IU/L.Patients with values between 10 and 100 IU/L were considered 'low responders' while patients with an antibody titer higher than 1000 IU/L were considered 'high responders'.RESULTS:No significant difference in age,gender,duration of illness,and years of gluten intake was found between the two groups.We found a high percentage of 'responders' after the first booster dose(ID = 76.7%,IM = 78.6%) and a greater increase after the third dose(ID = 90%,IM = 96.4%) of vaccine in both groups.Moreover we found a significantly higher number of high responders(with an anti-HBs antibody titer > 1000 IU/L) in the ID(40%) than in the IM(7.1%) group,and this difference was evident after the first booster dose of vaccination(P < 0.01).No side effects were recorded in performing delivery of the vaccine by either the ID or IM route.CONCLUSION:Our study suggests that both ID and IM routes are effective and safe options to administer a booster dose of HBV vaccine in celiac patients.However the ID route seems to achieve a greater number of high responders and to have a better cost/benefit ratio. | Salvatore Leonardi Andrea Domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa | 2012 | World Journal of Gastroenterology2012，18，40： | 2 |
| 2 | Evaluation and management of pedi- atric febrile seizures in the emergency department显示文摘 | Hampers LC Spina LA | 2011 | Emerg Med Clin North Am2011，29，1： | 1 |
| 3 | Mirtazapine in the treatment of essential tremor:an open-label,observer-blind study显示文摘 | Uccellini D Grampa G La Spina I | | 0，，01： | 1 |
| 4 | Ischaemic stroke in young people:A prospective and long-term follow-up study显示文摘 | Musolino R La Spina P Granata A | 2003 | Cerebrovase Dis2003，15，： | 1 |
| 5 | Influence of concurrent electrothermal and avalanche effects on the safe operating area of multifinger bipolar transistors显示文摘 | LA SPINA L dALESSANDRO V RUSSO S | 2009 | IEEE Trans Elec Dev2009，56，3： | 1 |
| 6 | IL28B, HCV core mutations, and hepatocellular carcinoma: does host genetic make-up shape viral evolution in response to immunity?显示文摘 | Luca Valenti Edoardo Pulixi Susanna La Spina | 2012 | Hepatology International2012，，1： | 1 |
| 7 | Isehaemic stroke in young people : a prospective and long-term follow-up study 显示文摘 | Musolino R La Spina P Granata A | 2003 | Cerebrovasc Dis2003，15，12： | 1 |
| 8 | Aluminum nitride for heatspreading in RF IC’s显示文摘 | L. La Spina E. Iborra H. Schellevis M. Clement J. Olivares L.K. Nanver | 2008 | Solid State Electronics2008，，9： | 1 |
| 9 | Intravitrealbevacizumab for nonsubfoveal choroidal neovascularization associatedwith angioid streaks 显示文摘 | BattagliaParodi M Iacono P La Spina C | 2014 | Am J Ophthalmol2014，157，2： | 1 |
| 10 | Pharmacokinetics and tissue distribution of pterostilbene in the rat 显示文摘 | Azzolini M La Spina M Mattarei A | 2014 | Mol Nutr Food Res2014，58，11： | 1 |
| 11 | Evidence for anti-VEGF treatment of diabetic macular edema显示文摘 | Bandello F Berchicci L La Spina | 2012 | OphthalmicRes2012，48，： | 1 |
| 12 | Presentation of childhood acute myeloid leukemia with erythema nodosum 显示文摘 | La Spina M Russo G | 2007 | J Clin Oncol2007，25，25： | 1 |
| 13 | Prevalence of pro- thrombotic polymorphisms in a selected cohort of crypto- genic and noncryptogenic ischemic stroke patients 显示文摘 | Calabro RS La Spina P Serra S | 2009 | Neurol India2009，57，5： | 1 |
| 14 | Dental pulp stem cells: State of the art and suggestions for a true translation of research into therapy显示文摘 | Marcella La Noce Francesca Paino Anna Spina Pasqualina Naddeo Roberta Montella Vincenzo Desiderio Alfredo De Rosa Gianpaolo Papaccio Virginia Tirino Luigi Laino | 2014 | Journal of Dentistry2014，，： | 1 |
| 15 | Hepatitis B vaccination failure in celiac disease: Is there a need to reassess current immunization strategies?显示文摘 | S. Leonardi M. Spina L. Spicuzza N. Rotolo M. La Rosa | 2009 | Vaccine2009，，43： | 1 |
| 16 | A Biomimetic Approach to Robot Locomotion in Unstructured and Slippery Environments显示文摘While much attention has been given to bio-robotics in recent years, not much of this has been given to the challenging subject of locomotion in slippery conditions. This study begins to rectify this by proposing a biomimetic approach to generating the friction required to give sufficient propulsive force on a slippery substrate. We took inspiration from a successful biological solution-that of applying hair-like structures to the propulsive appendages, similar to the setae found in nereid polychaetes living in muddy habitats. We began by examining the morphology and themean locomotion parameters of one of the most common nereids: Nereis diversicolor. Following this study, we designed and fabricated a robotic system with appendages imitating the biological shape found in the worm. A flexible control system was developed to allow most of the locomotion parameters observed in the real worm to be applied to the robot. Experiments on three different natural substrates ranging from fine sand to gravel showed that, whereas a plate attached to the appendage generated most thrust on a small particle substrate, a bundle of artificial setae attached to the appendage generated most thrust on a large particle substrate. On all types of substrate tested, an appendage without any attachment did significantly worse than one with. This suggests that hair-like structures can be advantageous. | Giovanni La Spina Thomas Hesselberg John Williams Julian F V Vincent | 2005 | Journal of Bionic Engineering2005，2，1： | 0 |
| 17 | Electromechanical Aspects of an Experimental Hybrid Vehicle显示文摘 | Silvano R. Rossi Roberto J. de la Vega Roberto C. Leegstra Guillermo A. Santillan Patricia M. Ciancio Marcelo A. Spina Maria H. Peralta Leonel O. Pico | 2015 | Journal of Mechanics Engineering and Automation2015，5，6： | 0 |
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