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| 1 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 2 | A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity显示文摘AIM: To investigate H+, K+-ATPase inhibition, anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H+, K+-ATPase and gastric mucin levels were determined to assess the anti- ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H+, K+-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H+, K+-ATPase in vitro, at an IC50 of 77 μg/mL as opposed to that of 19.3 μg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 μg/mL. In addition, free radical scavenging (IC50-40 μg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H+, K+-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management. | BM Srikanta MN Siddaraju Shylaja M Dharmesh | 2007 | World Journal of Gastroenterology2007，13，39： | 6 |
| 3 | Mi R-122 in hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV) and hepatitis C virus(HCV) infections are the most common causes of chronic liver diseases and hepatocelluar carcinomas. Over the past few years, the liver-enriched micro RNA-122(mi R-122) has been shown to differentially regulate viral replication of HBV and HCV. It is notable that thelevel of mi R-122 is positively and negatively regulated by HCV and HBV, respectively. Consistent with the welldocumented phenomenon that mi R-122 promotes HCV accumulation, inhibition of mi R-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans. On the other hand, mi R-122 is also known to block HBV replication, and HBV has recently been shown to inhibit mi R-122 expression; such a reciprocal inhibition between mi R-122 and HBV suggests an intriguing possibility that mi R-122 replacement may represent a potential therapy for treatment of HBV infection. As HBV and HCV have shared transmission routes, dual infection is not an uncommon scenario, which is associated with more advanced liver disease than either HBV or HCV mono-infection. Thus, there is a clear need to further understand the interaction between HBV and HCV and to delineate the role of mi R-122 in HBV/HCV dual infection in order to devise effective therapy. This review summarizes the current understanding of HBV/HCV dual infection, focusing on the pathobiological role and therapeutic potential of mi R-122. | Kyoungsub Song Chang Han Srikanta Dash Luis A Balart Tong Wu | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 4 | 以肝脏为靶器官的基因治疗时重组腺病毒引起的急性肝炎显示文摘目的 研究腺病毒为载体的基因治疗时淋巴细胞在肝组织免疫反应中的作用,探讨免疫抑制疗法在腺病毒载体基因治疗中的可行性。 方法 取8只恒河猴,经不同路径输入携带大肠杆菌lacZ基因或荧火虫荧光素酶基因luc的重组腺病毒6只。其中4只进行免疫抑制治疗。将含lacZ的质粒DNA注入2只动物作为对照。用免疫组织化学法检测β2-MG、HLA-DR、CD3、CD4、CD8及CD20。 结果 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多。腺病毒载体和转基因均与肝损害有关, 表现为一过性, 呈轻、中度无黄疸性肝炎。免疫抑制的动物只要处于免疫抑制状态下就没有肝炎的表现,基因表达的时间延长。质粒介导的基因转导效果差, 无肝损害及免疫反应。所有动物B淋巴细胞抗原CD20始终阴性。 结论 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多, 造成轻、中度一过性肝损害。使用免疫抑制药物可避免肝损害的发生并延长基因表达的时间。 | 鲁慧英 Deborah Sullivan Srikanta Dash Michael A Gerber | 2001 | 中华肝脏病杂志2001，9，5： | 3 |
| 5 | 印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用(英文)显示文摘目的:证实印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用。方法:雌性Sprague-Drawley大鼠在无菌状态下行双侧卵巢切除术后被分为5组(n=10)。检测NR/CAL/06的甲醇提取物(200和400mg/kg口服)的抗骨质疏松作用并以雷洛昔芬(5.4mg/kg口服)作为标准对照药,治疗时间为90d。实验前后测量各组大鼠的体质量、卵巢质量、骨质量、骨矿物质含量、骨强度,血清及尿液中的钙、磷含量及血清碱性磷酸酶含量。电镜下观察大鼠股骨外径、长度及厚度。结果:双侧卵巢切除术后,大鼠骨质量、骨矿物质含量及骨强度均有下降;电镜观察到卵巢切除大鼠股骨骨质疏松、多孔、破碎,且骨长度及厚度均有所下降。与假手术组相比,卵巢切除大鼠的血清钙、磷及碱性磷酸酶含量均有所升高,体质量及脂肪含量升高,子宫质量降低。NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗90d能够剂量依赖性地改变大鼠因卵巢切除所引起的上述各项指标变化,并将骨质量、骨矿物质含量、骨强度,血清钙、磷及碱性磷酸酶含量,体质量及脂肪含量恢复至正常水平。此外,经NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗的大鼠与卵巢切除模型组大鼠相比,电镜下股骨骨质孔形成减少,骨密度增加。结论:本实验的结果证实了NR/CAL/06的甲醇提取物具有很好的抗骨质疏松作用,可用于骨质疏松症的治疗。 | Praveen Srikanta Shivaprasad H.Nagarajappa Gollapalle L.Viswanatha. Mukund Handral Rajesh Subbanna Rangappa Srinath Ganesh Hiremath | 2011 | 中西医结合学报2011，9，10： | 2 |
| 6 | Surface functionalization of BiFeO3: A pathway for the enhancement of dielectric and electrical properties of poly(methyl methacrylate)-BiFe03 composite films显示文摘一部新奇二阶段的合成电影被作为陶器的 filler 作为聚合物矩阵和铋铁酸盐(BFO ) 扔 poly 采用的方法(甲基 methacrylate )(PMMA ) 的溶剂准备。BFO 的表面是由合适的 hydroxylating 代理人的 functionalized 激活他们的化学性质。合成电影的结构的分析证实由 functionalized BFO 组成的 composites (BFO -- 哦) 有弄歪的菱形的结构。词法分析显示出那 BFO -- 哦粒子同等地在聚合物矩阵上被散布。BFO 的 -OH 功能 -- 哦被 FTIR 证实。在到 1 MHz 的从 100 Hz 的一个频率范围的绝缘、电的研究揭示那 PMMA-(BFO -- 哦) composites 提高了绝缘的经常以及电的传导性,比未修改的 composites 的高得多。根据铁电体测量结果, hydroxylated 合成电影比未修改的的显示出优异铁电体行为,与残余的极化(2P 2.764 C/cm 2 的 r ) 。 | Mukesh Kumar MISHRA Srikanta MOHARANA Banarji BEHERA Ram Naresh MAHALING | 2017 | Frontiers of Materials Science2017，11，1： | 2 |
| 7 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 8 | Approximate covering detection among content-based subscriptions using space filling curves显示文摘 | Zhenhui Shen Srikanta Tirthapura | 2012 | Journal of Parallel and Distributed Computing2012，，12： | 1 |
| 9 | Gastroprotee- rive properties of karanjin from Karanja ( Pongamia pinnata) seeds; Role as antioxidant and H + -K + -ATPase inhibitor显示文摘 | Vismaya L Srikanta M B Rajashekhar S | 2011 | Evid-based Compl Alt2011，2011，74： | 1 |
| 10 | Characterisation of a starch-hydrolysis enzyme of Aspergillus niger 显示文摘 | Suresh C Dubey A K Srikanta S | 1999 | Appl Microbiol Biotechnol1999，51，： | 1 |
| 11 | Simulation of X-ray and gamma-ray detector response and spectral deconvolution 显示文摘 | Srikanta Sinha | 2006 | Advances in Space Research2006，，38： | 1 |
| 12 | Comparing the Performance of Neural Networks Developed by Using Levenberg-Marquardt and Quasi-Newton with the Gradient Descent Algorithm for Modelling a Multiple Response Grinding Process显示文摘 | Indrajit Mukherjee Srikanta Routroy | 2012 | Expert Systems with Ap- plications2012，，39： | 1 |
| 13 | Follicle-stimulating hormone receptor DNA sequencing:investigation into possible glycoprotein re- ceptor mutation in Van Wyk-Grumbach syndrome显示文摘 | Sanjeevaiah AR Vassart G Srikanta SS | 2008 | Endocr Pract2008，14，5： | 1 |
| 14 | Epoxidation of cottonseed oil by aqueous hydrogen peroxide catalyzed by liquid inorganic acid 显示文摘 | Srikanta D Anand V P Vaibhanv V G | 2008 | Bioresource Technology2008，99，9： | 1 |
| 15 | Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance 显示文摘 | Bi X Srikanta D Fanti L | 2005 | Proc Natl Acad Sci U S A2005，102，15： | 1 |
| 16 | Special issues on sensor networks and applications 显示文摘 | Hamid G Srikanta P K | 2003 | Proceeding of the IEEE2003，91，8： | 1 |
| 17 | Cryptococcus neofor- mans: historical curiosity to modem pathogen 显示文摘 | Srikanta D Santiago-Tirado FH Doering TL | 2014 | Yeast2014，31，2： | 1 |
| 18 | Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute显示文摘 | Belagihalli M. Srikanta Mysore A. Harish Nayaka Shylaja M. Dharmesh | 2011 | Biochimie2011，，4： | 1 |
| 19 | Carbon nanocells and nanotubes grown in hydrothermal fluids显示文摘 | Jose M Calderon M Srikanta S | 2000 | Chemical Physics Letters2000，329，： | 1 |
| 20 | Effect of ageing of sisal fibres on properties of sisal - Polypropylene composites显示文摘 | Mukhopadhyay S Srikanta R | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
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