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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Wave Runup on Smooth and Rock Slopes of Coastal Structures显示文摘 | J W Van de Meer C M Stain | 1992 | Journal Waterway Port Coastal and Ocean Eng ASCE1992，118，5： | 1 |
| 3 | Randomised placebo-controlled trial of anticoagulant treatment with low molecular weight heparin for cerebral sinus thrombosis 显示文摘 | Dc-Bruijn SF Stain J | 1999 | Stroke1999，30，4： | 1 |
| 4 | The relative denstities of red (Cervus elaphus) and roe (Capreolus capreolus) deer and their relationship in Scottish plantation forests显示文摘 | Latham J BW Staines & ML Gorman | 1996 | J Zool Lond1996，240，： | 1 |
| 5 | Cell-to-cell interactions in bone 显示文摘 | Stains J P Civitelli R | 2005 | Bioehem Biophys Res Commun2005，328，： | 1 |
| 6 | Hemophagocytic lymphohistiocytic syndrome:unrecognized cause of multiple organ failure显示文摘 | Nahum E Ben-Ari J Stain J | 2000 | Pediatr Crit Care Med2000，1，1： | 1 |
| 7 | Preparation and certification of Re-Os dating reference materials:Molybdenite HIP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 8 | Robustness with observers显示文摘 | Doyle J C Stain G | 1979 | IEEE Transaction on Automatic Control1979，24，4： | 1 |
| 9 | Characterization of a pollen-expressed gene encoding a putative pectin esterase of Petunia inflata显示文摘 | Mu J H Stains J P Kao T | 1994 | Plant Mol Siol1994，，3： | 1 |
| 10 | Low fre- quency of the Mx allele for viral resistance predates recent intensive select ion in domestic chickens显示文摘 | Balkissoon D Staines K Mc Cauley J | 2007 | Immuno Genet2007，59，8： | 1 |
| 11 | Prionispa houjayi (Coleoptera: Chrysomelidae: Cassidinae: Oncoce- phalini), a newly recorded genus and new species from Taiwan, with a description of its immature stages and notes on its bionomy显示文摘 | LEE C F SWItTOJA/qSKA J STAINES C L | 2009 | Zoological Studies2009，48，4： | 1 |
| 12 | Environmental burden of disease from exposure to lead in Ireland 显示文摘 | O'Connell E Staines A J Fry | 2006 | Epidemiology2006，17，6： | 1 |
| 13 | Beta-catenin and BM P-synergize to promote osteoblast differentiation and new hone formation 显示文摘 | MbMadele G Sheikh S Stains J P | 2005 | J Cell Biol Chem2005，94，2： | 1 |
| 14 | Robustness with observers,IEEE transaction of automatic control显示文摘 | Stain G | 1979 | AC-24(4):607-6111979，24，4： | 1 |
| 15 | Early replication in pulmonary B cells after infection with Marek’s disease herpesvirus by the respiratory route 显示文摘 | Baaten B J Staines K A Smith L P | 2009 | Viral Immunol2009，22，6： | 1 |
| 16 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 17 | Chitinase and laminarinase production in liquid culture by Trichoderma spp and their role in biocontrol of wood decay fungi 显示文摘 | Srinivasam U Staines H J | 1995 | International Biodeterioration & Biodegradation1995，，： | 1 |
| 18 | Highly stable low-noiseBrillouin fiber laser with ultranarrow spectral linewidth显示文摘 | Geng J Staines S Wang Z | 2006 | IEEE Photonics Technology Letters2006，18，17： | 1 |
| 19 | Characterization of a pollenexpressed gene encoding a putative pectin esterase of petunia inflate显示文摘 | MU J H STAINS J P KAO T | | Plant Mol Biol0，25，3： | 1 |
| 20 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A D Wu S Q Sun D Z Wang S X Qu W J Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
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