维普中文期刊产品整合服务
3篇 您的检索式:作者名="Stephan Rohr"
    题名 作者 年代 出处 被引量
1Tribological and Corrosion Behavior of Vacuum Plasma Sprayed Ti-Zr-Ni Quasicrystalline Coatings显示文摘Stephan Siegmann Philippe Kern Lukas Rohr Partha P. Bandyopadhyay 2007Journal of Thermal Spray Technology (-)2007,,5:1
2Optical recording system based on a fiber optic image conduit: assessment of microscopic activation patterns in cardiac tissue显示文摘 Jan P Kucera 1998Biophysics Journal1998,75,:1
3Nanovolcano microelectrode arrays: toward long- term on-demand registration of transmembrane action potentials by controlled electroporation显示文摘Volcano-shaped microelectrodes(nanovolcanoes)functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access.These nanovolcanoes exhibit recording characteristics similar to those of state-of-the-art micro-nanoelectrode arrays that use electroporation as an insertion mechanism.In this study,we investigated whether the use of electroporation improves the performance of nanovolcano arrays in terms of action potential amplitudes,recording durations,and yield.Experiments with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings,as they enabled multiple on-demand registration of intracellular action potentials with amplitudes as high as 62 mV and parallel recordings in up to~76%of the available channels.The performance of nanovolcanoes showed no dependence on the presence of functionalized nanopatterns,indicating that the tip geometry itself is instrumental for establishing a tight seal at the cell–electrode interface,which ultimately determines the quality of recordings.Importantly,the use of electroporation permitted the recording of attenuated cardiomyocyte action potentials during consecutive days at identical sites,indicating that nanovolcano recordings are nondestructive and permit long-term on-demand recordings from excitable cardiac tissues.Apart from demonstrating that less complex manufacturing processes can be used for next-generation nanovolcano arrays,the finding that the devices are suitable for performing on-demand recordings of electrical activity from multiple sites of excitable cardiac tissues over extended periods of time opens the possibility of using the devices not only in basic research but also in the context of comprehensive drug testing.Benoit X.E.Desbiolles Etienne de Coulon Nicolas Maino Arnaud Bertsch Stephan Rohr Philippe Renaud 2020Microsystems & Nanoengineering2020,6,1:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费