|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Con- ducting polymer microactnators operating in air显示文摘 | Gursel Alici Valerie Devaud Philippe Renaud | 2009 | J Mi- cromech Microeng2009，19，02501： | 1 |
| 2 | Complete sequence of a novel highly divergent simian T-cell lymphotropic virus from wild-caught red-capped mangabeys (Cercocebus torquatus )from Cameroon: a new primate T-lymphotropic virus type 3 subtype 显示文摘 | Laurent M Renaud M Philippe M | 2002 | J Virology2002，76，1： | 1 |
| 3 | The extraction of creatinine from a physiological medium by a microporous solid and its quantification by diffuse reflectance UV spectroscopy显示文摘 | David Bergé-Lefranc Oliver Sch?f Renaud Denoyel Jean-Louis Bergé-Lefranc Régis Guieu Philippe Brunet Virginie Hornebecq | 2009 | Microporous and Mesoporous Materials2009，，1： | 1 |
| 4 | Impact of Pre-Transplant Liver Hemodynamics and Portal Reconstruction Techniques on Post-Transplant Portal Vein Complications in Pediatric Liver Transplantation: A Retrospective Analysis in 197 Recipients显示文摘 | Catherine de Magnée Christophe Bourdeaux Florence De Dobbeleer Magdalena Janssen Renaud Menten Philippe Clapuyt Raymond Reding | 2011 | Annals of Surgery2011，，1： | 1 |
| 5 | Postendoscopic duodenal hematoma in children: Ultrasound diagnosis and follow‐up显示文摘 | Dana Dumitriu Renaud Menten Fran?oise Smets Philippe Clapuyt | 2014 | J. Clin. Ultrasound2014，，： | 1 |
| 6 | Low power techniques applied to a 80C51 microeontroller for high temperature applications 显示文摘 | Philippe Manet David Bol Renaud Ambroise | 2006 | Journal of Low Power Electronics2006，2，10： | 1 |
| 7 | Organoboranes as a Source of Radicals显示文摘 | Cyril Ollivier Philippe Renaud | 2001 | Chemical Reviews2001，101，11： | 1 |
| 8 | Tunnel junctions in a III-V nanowire by surface engineering显示文摘 | Salman Nadar Chloe Rolland Jean-Frangois Lampin Xavier Wallart Philippe Caroff Renaud Leturcq | 2015 | Nano Research2015，8，3： | 1 |
| 9 | The vastus lateralis neuromuscular activity during all-out cycling exercise 显示文摘 | STEPHANE B RENAUD H PHILIPPE R | 2009 | J Electromyography Kinesiol2009，，19： | 1 |
| 10 | Organoboranes as a source of radicals显示文摘 | Cyril Ollivier Philippe Renaud | 2001 | Chemical Reviews2001，101，11： | 1 |
| 11 | Sonographic assessment of the retroperitoneal position of the third portion of the duodenum: an indicator of normal intestinal rotation显示文摘 | Renaud Menten Raymond Reding Véronique Godding Dana Dumitriu Philippe Clapuyt | 2012 | Pediatric Radiology2012，，8： | 1 |
| 12 | Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids显示文摘A concise route for the preparation of two simple optically pure indolizidin-5-ones has been developed.The key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected 2-vinylpyrrolidines.By using complementary strategies,these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5)and their conversion to a variety of indolizidine alkaloids such as coniceine,indolizidine 209D and 167B,5-epi-indolizidine 249A and monomorine has been reported in the literature. | Sankar Rao Suravarapu Bettina Peter Philippe Renaud | 2019 | Science China Chemistry2019，62，11： | 1 |
| 13 | Nanovolcano microelectrode arrays: toward long- term on-demand registration of transmembrane action potentials by controlled electroporation显示文摘Volcano-shaped microelectrodes(nanovolcanoes)functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access.These nanovolcanoes exhibit recording characteristics similar to those of state-of-the-art micro-nanoelectrode arrays that use electroporation as an insertion mechanism.In this study,we investigated whether the use of electroporation improves the performance of nanovolcano arrays in terms of action potential amplitudes,recording durations,and yield.Experiments with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings,as they enabled multiple on-demand registration of intracellular action potentials with amplitudes as high as 62 mV and parallel recordings in up to~76%of the available channels.The performance of nanovolcanoes showed no dependence on the presence of functionalized nanopatterns,indicating that the tip geometry itself is instrumental for establishing a tight seal at the cell–electrode interface,which ultimately determines the quality of recordings.Importantly,the use of electroporation permitted the recording of attenuated cardiomyocyte action potentials during consecutive days at identical sites,indicating that nanovolcano recordings are nondestructive and permit long-term on-demand recordings from excitable cardiac tissues.Apart from demonstrating that less complex manufacturing processes can be used for next-generation nanovolcano arrays,the finding that the devices are suitable for performing on-demand recordings of electrical activity from multiple sites of excitable cardiac tissues over extended periods of time opens the possibility of using the devices not only in basic research but also in the context of comprehensive drug testing. | Benoit X.E.Desbiolles Etienne de Coulon Nicolas Maino Arnaud Bertsch Stephan Rohr Philippe Renaud | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
| 14 | MP联合沙利度胺、MP和低强度自体干细胞移植治疗老年多发性骨髓瘤(IFM99—06):一项随机试验显示文摘背景对于老年人多发性骨髓瘤,马法兰与泼尼松联合化疗方案(MP)目前仍被认为是标准治疗方案。本试验旨在评价在MP方案的基础上联用沙利度胺或低强度的自体干细胞移植能否提高患者的存活率。
方法从2000年5月22日到2005年8月8日,共招募447例初治多发性骨髓瘤患者,年龄65~75岁,随机接受MP方案(n=196)、MP联合沙利度胺方案(MPT,n=125)或低强度(马法兰,100mg/m^2)的自体干细胞移植方案(MEL100,n=126)。主要终点为总体存活率。采用意向治疗分析。本试验已在ClinicalTrials.gov注册,注册号为NCT00367185。
结果中位随访51.5个月(IQR34.4~63.2),中位总体存活时间:MP组为33.2个月(13.8~54.8),MPT组为51.6个月(26.6~未到达),MELl00组为38.3个月(13.0~61.6)。在中位总体存活率方面,MPT方案优于MP方案(HR0.59,95%C10.46~0.81:P=0.0006)或MEL100方案(HR0.69,95%C10.49~0.96;P=0.027)。而MEL100方案和MP方案无差异(HR0.86,95%C10.65~1.15;P=0.32)。
结论试验结果提示,MPT方案目前应作为老年多发性骨髓瘤初治的推荐方案。 | Thierry Facon Jean Yves Mary Cyrille Hulin Lotfi Benboubker Michel Attal Brigitte Pegourie Marc Renaud Jean Luc Harou-sseau Gaelle Guillerm Carine Chaleteix Mamoun Dib Laurent Voillat Herve Maisonneuve Jacques Troncy Veronique Dorv-aux Mathieu Monconduit Claude Martin Philippe Casassus Jerome Jaubert Henry Jardel Chantal Doyen Brigitte Kolb Bruno Anglaret Bernard Grosbois Ibrahim Yakoub-Agha Claire Mathiot Herve Avet-Loiseau 王鸿鹄(译) | 2008 | 世界临床医学2008，2，1： | 0 |
| 15 | Impedance spectroscopy of the cell/nanovolcano interface enables optimization for electrophysiology显示文摘Volcano-shaped microelectrodes have demonstrated superior performance in measuring attenuated intracellular action potentials from cardiomyocyte cultures. However, their application to neuronal cultures has not yet yielded reliable intracellular access. This common pitfall supports a growing consensus in the field that nanostructures need to be pitched to the cell of interest to enable intracellular access. Accordingly, we present a new methodology that enables us to resolve the cell/probe interface noninvasively through impedance spectroscopy. This method measures changes in the seal resistance of single cells in a scalable manner to predict the quality of electrophysiological recordings. In particular, the impact of chemical functionalization and variation of the probe’s geometry can be quantitatively measured. We demonstrate this approach on human embryonic kidney cells and primary rodent neurons. Through systematic optimization, the seal resistance can be increased by as much as 20-fold with chemical functionalization, while different probe geometries demonstrated a lower impact. The method presented is therefore well suited to the study of cell coupling to probes designed for electrophysiology, and it is poised to contribute to elucidate the nature and mechanism of plasma membrane disruption by micro/nanostructures. | Nicolas Maïno Arnaud Bertsch Philippe Renaud | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员