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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://cuke.hort.ncsu.edu/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 5 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | Prospective follow-up study between 3 and 15 months after stroke:improvements and decline in cognitive function among dementia-free stroke survivors > 75 years of age显示文摘 | Ballard C Rowan E Stephens S | 2003 | Stroke2003，34，10： | 1 |
| 8 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 9 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 10 | A two-stage intelligent search algorithm for the two-dimensional strip packing problem 显示文摘 | Stephen C L Zhang Defu Kwang M S | 2011 | European Journal of Operational Research2011，215，： | 1 |
| 11 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘 | Zhang T Geoffrey S E Stephen C R etal | 2012 | Organic Geo- chemistry2012，47，： | 1 |
| 12 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 13 | Assessing innovation in emerging energy technologies:Socio-technical dynamics of carbon capture and storage (CCS) and enhanced geothermal systems (EGS) in the USA显示文摘 | Stephens J C Jiusto S | | 0，，04： | 1 |
| 14 | Host-microbe interactions:shaping the evolution of the plant immune response显示文摘 | Stephen T C Gitta C Brad D Brian J S | 2006 | Cell2006，124，4： | 1 |
| 15 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 16 | Pharmacokineti cs of an oral solution of the microemulsion formulation of cyclosporine in main tenance pediatric liver transplant recipients显示文摘 | Stephen D Gerard C John S | 1997 | Transplantation1997，63，12： | 1 |
| 17 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 18 | Synthesis and biological activity of unsymmetrical bis-steroida pyrazines related to the cytotoxic marine natural product eephalostatin 1 显示文摘 | Clayton H H Stephen C S | 1994 | J Org Chem1994，59，： | 1 |
| 19 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | 2012 (9814)2012，，9814： | 1 |
| 20 | The effect of mode of exercise on fat oxidation during exercise显示文摘 | STEPHEN C G VERONICA J S DEVONNA A | 1999 | J Strength Condition Res1999，13，1： | 1 |
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