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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 3 | Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study显示文摘 | Jorg Petersen Vlad Ratziu Maria Buti Harry L.A. Janssen Ashley Brown Pietro Lampertico Jan Schollmeyer Fabien Zoulim Heiner Wedemeyer Martina Sterneck Thomas Berg Christoph Sarrazin Marc Lutgehetmann Peter Buggisch | 2011 | Journal of Hepatology2011，，3： | 2 |
| 4 | Selection of the living liver donor显示文摘 | Sterneck MR Fischer L Nischwitz U Burdelski M Kjer S. Latta A Malago M Petersen J Pothmann W Rogiers X | | 0，，： | 1 |
| 5 | In Situ Splitting of Cadaveric Livers: The Ultimate Expansion of a Limited Donor Pool显示文摘 | Xavier Rogiers Massimo Malagó Karim Gawad Karl W. Jauch Michael Olausson Wolfram T. Knoefel Matthias Gundlach Atef Bassas Lutz Fischer Martina Sterneck Martin Burdelski Christoph E. Broelsch | 1996 | Annals of Surgery1996，，3： | 1 |
| 6 | Neonatal fulminant hepatitis B: structural and functional analysis of complete hepatitis B virus genomes from mother and infant显示文摘 | Kalinina T Otto S | 1998 | J Infect Dis1998，177，5： | 1 |
| 7 | CCAAT/enhancer binding protein-b is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic ras signalling显示文摘 | Zhu S Yoon K Sterneck E | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 8 | Low recurrence of pre-existing extrahepatic malignancies after liver transplantation 显示文摘 | Benten D Sterneck M Panse J | 2008 | Liver Transpl2008，14，： | 1 |
| 9 | Prevalence, incidence, and clinical relevance of the reverse transcriptase V207I mutation outside the YMDD motif of the hepatitis B virus polymerase dur- ing lamivudine therapy显示文摘 | Zllner B Sterneck M Wursthorn K | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 10 | Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis显示文摘 | STERNECK E ZHU S RAMIREZ A | 2006 | Oncogene2006，25，8： | 1 |
| 11 | Low recurrence of preexisting extrahepatic malignancies after liver transplan- tation显示文摘 | BENTEN D STERNECK M PANSE J | 2008 | Liver Transpl2008，14，6： | 1 |
| 12 | Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells 显示文摘 | Sterneck E Kaplan DR Johnson PF | 1996 | J Neurochem1996，67，4： | 1 |
| 13 | Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis显示文摘 | Sterneck M Gunther S Gerlach J | 1997 | J Hepatol1997，26，4： | 1 |
| 14 | Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1 显示文摘 | Cantwell CA Sterneck E Johnson PF | 1998 | Mol Cell Biol1998，18，4： | 1 |
| 15 | Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation显示文摘 | Sterneck M Gunther S Santantonio T | 1996 | Hepatology1996，24，： | 1 |
| 16 | Clinical reactivation after liver transplantation with an unusual minor strain of hepatitis B virus in an occult carrier 显示文摘 | Zollner B Feucht HH Sterneck M | 2006 | Liver Transpl2006，12，8： | 1 |
| 17 | Split liver transplantation and risk to the adult recipient: analysis using matched pairs显示文摘 | Dieter C Broering Stefan Topp Ulrich Schaefer Lutz Fischer Matthias Gundlach Martina Sterneck Volker Schoder Werner Pothmann Xavier Rogiers | 2002 | Journal of the American College of Surgeons2002，，5： | 1 |
| 18 | Repression of the inhibin alpha-subunit gene by the transcription factor CCAAT/enhancer-binding protein-beta显示文摘 | Burkart AD Mukherjee A Sterneck E | 2005 | Endocrinology2005，146，4： | 1 |
| 19 | Neonatal fulminant hepatitis B: structural and functional analysis of complete hepatitis B virus genomes from mother and infant显示文摘 | Sterneck M Kalinina T Otto S | 1998 | J Infect Dis1998，177，5： | 1 |
| 20 | Ableitung Zahlentheoretischer Relationen Mit Hilfe Eines Mehrdimensionalen Systemes Von Gitter punkten 显示文摘 | STERNECK R D | | Monatscheffe MathPhys0，1894，8： | 1 |
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