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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | 脉冲涡流和电磁声换能器双探头无损检测显示文摘在许多情况下,只应用一种NDT技术存在不足,这就迫使NDT操作人员使用一种以上的技术以保证检测出危害被检物使用寿命或功能的缺陷。但分别实施多种技术的检测,就会延长检验时间。介绍了一种新的NDT设施,采用两种不同的非接触无损检测技术进行互补,即电磁声换能器(EMAT)和脉冲涡流(PEC)探头。检测结果表明,脉冲涡流和电磁声换能器因是非接触,所以可应用于材料生产过程中的自动在线检验,也可用于在役检验。 | Ali Sophian Rachel S Edwards 田贵云 Steve Dixon 马铭刚 | 2007 | 无损检测2007，29，8： | 4 |
| 3 | 指南儿童毛细支气管炎:NICE指南概要显示文摘本文是英国医学杂志发布的基于现有最佳证据得出的系列新指南概要之一。它们重点对临床实践提供重要建议,尤其是尚无定论或存有争议的领域。 | Valentina Ricci research fellow Vanessa Delgado Nunes senior research fellow and guideline lead M Stephen Murphy clinical director for children's guidelines Steve Cunningham consultant and honorary reader in paediatric respiratory medicine 许菲 梁志欣 | 2015 | 英国医学杂志中文版2015，0，12： | 4 |
| 4 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 5 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 6 | Medical Therapy for Pulmonary Arteri- al Hypertension: updated ACCP evidence-based clinical practice guidelines 显示文摘 | David B Steve H Gregory S | 2004 | Chest2004，126，17： | 1 |
| 7 | Density functional study of cluster models of zeolites 1 Structure and acidity of hydroxyl groups in disioxane analogs显示文摘 | STEVE M S NICHOLAS J B | 1993 | J Phys Chem1993，97，38： | 1 |
| 8 | Seismic attribute technology for reservoir forecasting and monitoring显示文摘 | Chen Q Steve S | | The Leading Edge0，16，5： | 1 |
| 9 | Seismic attribut technology for reservoir forecasting and monitoring显示文摘 | Chen Q Steve S | 1997 | The Leading Edge1997，16，5： | 1 |
| 10 | Verification of the acute physiology and chronic health evaluation scoring system in a Hong Kong intensive care unit显示文摘 | Teike OH Robert H Steve S | 1993 | Crit Care Med1993，21，5： | 1 |
| 11 | Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord 显示文摘 | Steve S Kang DY Mujtaba T | 2002 | Exp Neurol2002，177，： | 1 |
| 12 | Seismic attribute technology for reservoir forecasting and monitoring显示文摘 | Chen Q Steve S | 1997 | The leading Edge1997，16，5： | 1 |
| 13 | Regional geology and geophysics of the eastern Gulf of Guinea (Niger Delta to Rio Muni)显示文摘 | Steve R L Munday S Bray R | 2002 | The Leading Edge2002，10，： | 1 |
| 14 | Phthalates:toxicogenomics and inferred human diseases显示文摘 | SHER S STEVE S L | 2011 | Genom2011，97，3： | 1 |
| 15 | Mechanism of thaumasite formation in concrete slabs on grade in southern califomia显示文摘 | SADANAND S STEVE B NIELS T | 2003 | Cement & Concrete Composites2003，25，8： | 1 |
| 16 | Low-k damage re- duction using a modified plasma strip process 显示文摘 | RAJESH M BING J STEVE S | 2010 | Solid-State- Technology2010，53，5： | 1 |
| 17 | Characterization of nanocellulose-reinforced shape memory polyurethanes显示文摘 | Auad M L Contos V S Nutt Steve | 2008 | Poly Int2008，57，： | 1 |
| 18 | Backscattered electron imaging to determine water-to-cement ratio of hardened concrete显示文摘 | BADQER STEVE R SADANANDA S | 2001 | Transportation Research Record2001，31，1： | 1 |
| 19 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 20 | Metformin effects on treatment satisfaction and quality of life in gestational diabetes显示文摘 | Lamis L Steve H Hassan S | 2013 | Br J Dia Vas Dis2013，13，4： | 1 |
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