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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | Analysis of air gap flux current and vibration signals as a function of the combination of static and dynamic air-gap eccentricity in 3-phase induction motors显示文摘 | David G Dorrell William T Thomson Steven Roach | 1997 | IEEE Transactions on Industry Applications1997，33，1： | 1 |
| 4 | Apparent digestibility of gross nutrients from feedstuffs in extruded feeds for rainbow trout (Oncorhynchus mykiss ) 显示文摘 | GAYLORD T G BARROWS F T STEVEN D R | 2008 | Journal of the World Aquaculture Society2008，39，6： | 1 |
| 5 | Host plant resistance to blackmargined aphids on pecan显示文摘 | Tommy E T Grauke L J Steven G S | 2000 | Journal American Pomological Society2000，54，4： | 1 |
| 6 | Study of dementia subtypesin the community显示文摘 | Stevens T Livingston G Kitchen G | 2002 | BrJ Psychiatry2002，180，： | 1 |
| 7 | Finding drug targets in microbial genomes 显示文摘 | Timothy D R Steven R G Herve T | 2001 | Res Focus2001，6，17： | 1 |
| 8 | High-performance high-speed steels by design显示文摘 | Steven G Nehrenberg A E Philip T V | 1964 | Trans ASM1964，57，64： | 1 |
| 9 | Demonstration of preferential binding of SYBR Green Ⅰ to specific DNA fragments in real-time multiplex PCR显示文摘 | Steven G Paul T Monis | 2003 | Nucl Acids Res2003，31，22： | 1 |
| 10 | Micromechanics models for mechanicaland thermomechanical properties of 3D through-thethicknessangle interlock woven composites 显示文摘 | TAN P T L STEVEN G P | 1999 | CompositesPart A:Applied Science and Manufacturing1999，30，： | 1 |
| 11 | Controlled multidose pharrnacwkinetic evaluation of two extended release carbamazepine formulations carbatro and tegreto 显示文摘 | STEVENS R E LIMSAKUN T EVANS G | 1998 | J Pharm Sci1998，87，12： | 1 |
| 12 | Orbital maneuvering with electrodynam- ie tethers显示文摘 | Steven G T Hakan S | 2003 | Journal of Guidance Control and Dynamics2003，26，5： | 1 |
| 13 | Visibility and aerosol composition in Houston,Texas显示文摘 | Dzubay T G Stevens R K Lewis C W | 1982 | Environ Sci Technol1982，16，8： | 1 |
| 14 | Two-dimensional growth medels显示文摘 | Williams H T C oodwin L Steven G | 1998 | Physics Letters A1998，250，2： | 1 |
| 15 | Controllable Surface Modification of Poly( lactic-co-glycolicacid) (PLGA) by Hydrolysis or Aminolysis I: Physical,Chemical, and Theoretical Aspects显示文摘 | Croll T I O'Connor A J Stevens G W Cooper-White J J | 2004 | Biomacromolecules2004，5，2： | 1 |
| 16 | Islington study of dementia subtypes in the community显示文摘 | Stevens T Livingston G Kitchen G | 2002 | Br J Psychiatry2002，180，： | 1 |
| 17 | Anomalous functional organi- zation of barrel cortex in GAP43 deficient mice 显示文摘 | Dubroff J G Stevens R T Hitt J | 2006 | Neuroimage2006，29，4： | 1 |
| 18 | Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone graft substitute,a bone graft expander, and a method for local antibiotic delivery 显示文摘 | Thomas M T Robert M U Steven G | 2001 | J Bone Joint Surg2001，83，2： | 1 |
| 19 | Preliminary formu- lation development for aqueous surfactant-based soybean oil ex traction显示文摘 | Do L D Stevens T L Kibbey T C G | 2014 | Industrial Crops and Products2014，，62： | 1 |
| 20 | Different molecular basis for spinal muscular atrophy in South African black patients显示文摘 | Stevens G Yawitch T Rodda J | 1999 | Am J Med Genet1999，86，5： | 1 |
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