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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Host plant resistance to blackmargined aphids on pecan显示文摘 | Tommy E T Grauke L J Steven G S | 2000 | Journal American Pomological Society2000，54，4： | 1 |
| 5 | Degradation of zao dye by environmental microorganisms and helminthes 显示文摘 | Chung K T Stevens S E | 1993 | Environ Toxical Chem1993，13，11： | 1 |
| 6 | The potential of brain natriunetic peptide as a biomarker for New York Heart Association class during the outpatient treatment of heart failure 显示文摘 | Lee S C Stevens T L Sandberg S M | 2002 | J Card Fail2002，8，3： | 1 |
| 7 | The potential of brain natriuretic peptide as a biomarker for New York Heart Association class during the out patient treatment of heart failure显示文摘 | Lee SC Stevens T L Sandberg S M | 2002 | J Card Fail2002，8，3： | 1 |
| 8 | The proto- toxin lynxl acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo显示文摘 | Miwa J M Stevens T R King S L | 2006 | Neu- ron2006，51，5： | 1 |
| 9 | Process requirements for achieving full-flow disinfection of recirculating water using ozonation and UV irradiation 显示文摘 | STEVEN T S MARK J S SCOTT M T | 2009 | Aquacuhural Engineering2009，40，1： | 1 |
| 10 | Economic analy- sis of the treatment of posterior epistaxis 显示文摘 | Miller T R Stevens E S Orlandi R R | 2005 | Am J Rhi- nol2005，19，1： | 1 |
| 11 | Mycoplasma hominis and ure- aplasma urealyticum in midtrimester amniotic fluid : Association with amniotic fluid cytokine levels and pregnancy outcome显示文摘 | Stephen T Robin B Steven S | 2004 | Am J Obstet Gyne- col2004，191，4： | 1 |
| 12 | 查看详情显示文摘 | Small H Stevens T S Bauman W C | | 0，，： | 1 |
| 13 | Comparison of the gravimetric,phenol red, and 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model显示文摘 | Steven C S Rinaldi M T Vukovinsky K E | 2001 | AAPS Pharm Sci2001，3，3： | 1 |
| 14 | Sedimentation and aliagenesis of Chinese loess: implications for the preservation of continuous high-resolution climate records显示文摘 | Stevens T Armitage S J Lu H | 2006 | Geology2006，34，： | 1 |
| 15 | High resolution derivative spectra显示文摘 | Demetriades S T H Steven M D Clark J A | 1990 | Remote Sensing Environ1990，33，： | 1 |
| 16 | Orbital maneuvering with electrodynam- ie tethers显示文摘 | Steven G T Hakan S | 2003 | Journal of Guidance Control and Dynamics2003，26，5： | 1 |
| 17 | Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality 显示文摘 | SHARSHAR T BASTUJI-GARIN S STEVEN R D | 2009 | Crit Care Med2009，37，12： | 1 |
| 18 | Converting an injectable protein therapeutic into an oral form: Phenylalanine ammonia lyase for phenylketonuria显示文摘 | KANG T S WANG L STEVENS R C | 2010 | Mol Genet Metab2010，99，1： | 1 |
| 19 | Ozonation and UV Irradiation:an Introduction and Examples of Current Applications 显示文摘 | Steven T S | 2003 | A Quacultural Engineering2003，28，： | 1 |
| 20 | Economic analysis of the treatment of posterior epistaxis显示文摘 | MILLER T R STEVENS E S ORLANDI R R | 2005 | Am J Rhinol2005，19，： | 1 |
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