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| 1 | The cytokine milieu in the interplay of pathogenic Th1/ Th17 cells and regulatory T cells in autoimmune disease显示文摘The propagation and regulation of an immune response is driven by a network of effector and regulatory T(Treg)cells.The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting.In autoimmune diseases,this interplay shifts the balance in favor of the development of autoreactive effector T cells,resulting in inflammatory pathology.The objective of an effective therapeutic approach for autoimmune disease is to restore this balance.In this review,we describe the characteristics and development of pathogenic T helper 1(Th1)and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets.Given the importance of cytokines,we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. | Stewart Leung Xuebin Liu Lei Fang Xi Chen Taylor Guo Jingwu Zhang | 2010 | Cellular & Molecular Immunology2010，7，3： | 8 |
| 2 | Staging bone scintigraphy in nasopharyngeal carcinoma显示文摘 | Leung SF Stewart IE Tsao SY | 1991 | Clin Radiol1991，43，： | 1 |
| 3 | Staging bone scintig- raphy in nasopharyngeal carcinoma 显示文摘 | Leung SF Stewart IE Tsao SY | 1991 | Clin Radiol1991，43，5： | 1 |
| 4 | Factors contributing to the efficacy of concurrent–adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials显示文摘 | Anne W.M. Lee Stewart Y. Tung Roger K.C. Ngan Rick Chappell Daniel T.T. Chua T.X. Lu Lillian Siu Terence Tan L.K. Chan W.T. Ng T.W. Leung Y.T. Fu Gordon K.H. Au C. Zhao Brian O’Sullivan E.H. Tan W.H. Lau | 2010 | European Journal of Cancer2010，，5： | 1 |
| 5 | Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients: a longitudinal observational study 显示文摘 | Leung WY So WY Stewart D | 2009 | Cardiovasc Diabetol2009，8，： | 1 |
| 6 | Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia:targeted immunotherapy for acute lymphoblastic leukemia显示文摘The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.However,several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight,and thus its clinical use is limited.Furthermore,multiple trials have shown that approximately 30%of blinatumomab-relapsed cases are characterized by CD19 negative leukemic cells.Here,we design and characterize two novel antibodies,A-319 and A-2019.Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures,and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.Our in vitro,ex vivo,and in vivo experiments demonstrated that A-319 and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells,enhancing T-cell function,mediating B-cell depletion,and eventually inhibiting tumor growth in Raji xenograft models.The two molecules are complementary in terms of efficacy and specificity profile.The activity of A-319 demonstrated superior to that of A-2019,whereas A-2019 has an additional capability to target CD20 in cells missing CD19,suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells. | Sisi Wang Lijun Peng Wenqian Xu Yuebo Zhou Ziyan Zhu Yushan Kong Stewart Leung Jin Wang Xiaoqiang Yan Jian-Qing Mi | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 7 | The association between adolescents' depressive symptoms, maternal negative affect, and family relationships in Hong Kong: cross-sectional and longitudinal findings 显示文摘 | Leung SS Stewart SM Wong JP | 2009 | J Fam Psychol2009，23，5： | 1 |
| 8 | Left ventricular function after valve repair for chronic mitral regurgitation: predictive value of preoperative assessment of contractile reserve by exercise echocardiography显示文摘 | Leung DY Griffin BP Stewart WJ | 1996 | J Am Coll Cardiol1996，28，5： | 1 |
| 9 | Diurnal variation in pilocarpine-induced generalized tonic-clo-fic seizure activity显示文摘 | Stewart LS Leung LS Persinger MA | 2001 | Epilepsy Res2001，44，23： | 1 |
| 10 | Crucial role of interleukin-7in T helper type17survival and expansion in autoimmune disease显示文摘 | Liu Xue-bin Stewart Leung Jian Hong | 2010 | Nature medicine2010，16，2： | 1 |
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