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79篇 您的检索式：作者名="Strauch J"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells显示文摘	Griese DP Achatz S Batzlsperger CA Strauch UG Grumbeck B Weil J	2003	Cardiovasc Res2003，58，2：	1
3	查看详情显示文摘	Strauch F W Williams C J		0，，：	1
4	A dual-Doppler radar method for the determination of wind velocities within precipitating weather systems显示文摘	Miller L J Strauch R G	1974	Remote Sense Environ1974，3，40：	1
5	Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘	Obermeier F Dunger N Strauch UG Grunwald N Herfarth H Scholmerich J	2003	Clin Exp Immunol2003，134，2：	1
6	Minimally invasive transapical aortic valve implantation and the risk of acute kidney injury显示文摘	Strauch J T Scherner M P Haldenwang P L		0，，02：	1
7	The incidence of ganglion cysts and other variations in anatomy along the course of the suprascapular nerve显示文摘	Ticker JB Djurasovic M Strauch R J	2014	Shoulder and Elbow Surg2014，7，5：	1
8	Formation and structural properties of salicylaldiminato complexes of zirconium and titanium显示文摘	Strauch J Warren T H Erker G	2000	Inorganica Chimica Acta2000，，：	1
9	Autologous Schwann cells drive regeneration through a 6-cm autogenous venous nerve conduit 显示文摘	Strauch B Rodriguez DM Diaz J	2001	Recons tr Microsurg2001，17，8：	1
10	Pulsed magnetic fields ac- celerate cutaneous wound healing in rats显示文摘	Strauch B Patel M K Navarro J A et ol	2007	Plast Reconstr Surg2007，120，：	1
11	Bile salt stimulates intestinal epithelial cell migration through TGF β after wounding显示文摘	STRAUCH E D WANG J Y BASS B L	2001	J Surg Res2001，，97：	1
12	Characterization of degP,a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coil at high temperature显示文摘	Strauch K L Johnson K Beckwith J	1989	J Bacteriol1989，171，5：	1
13	Characterization of dcgP,a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature显示文摘	Strauch K L Johnson K Beckwith J	1989	Bacterioi1989，171，5：	1
14	Application of ECMO in muhitrauma patients with ARDS as rescue therapy显示文摘	Madershahian N Wittwer T Strauch J	2007	J Card Surg2007，22，3：	1
15	Application of ECMO in multitrauma patients with ARDS as rescue therapy显示文摘	MADERSHAHIAN N WITTWER T STRAUCH J	2007	Card Surg2007，22，3：	1
16	A dual-Doppler radar method for the determination of wind velocities within precipitating weather systems显示文摘	Strauch R G	1974	Remote Sens Environ1974，3，4：	1
17	Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta显示文摘	Strauch ED Yamaguchi J Bass BL	2003	J Am Coll Surg2003，197，6：	1
18	Formation of a butadienenickel-based zwitterionic singlecomponent catalyst for ethylene polymerization: an alternative activation pathway for homogeneous Ziegler-Natta catalysts of late transition metals显示文摘	STRAUCH J W ERKER G KEHR G	2002	Angew Chem Int Ed2002，41，14：	1
19	Vascular gene delivery of anticoagulants by transplantation of retrovirally transduced endothelial progenitor cell显示文摘	Griese DP Achatz S Batzlsperger CA Strauch UG Grumbec B Weil J	2003	Cardiovasc Res2003，58，2：	1
20	Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus? 显示文摘	Widimsky J Jr Strauch B Sindelka G	2001	Physiol Res2001，50，6：	1

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