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| 1 | Risk assessment of heavy metals in soils and vegetables around nonferrous metals mining and smelting sites,Baiyin,China显示文摘A field survey was conducted to investigate the metal and arsenic contamination in soils and vegetables on four villages (Shuichuan (SCH), Beiwan (BWA), Dongwan (DWA) and Wufe (WFE)) located along, Baiyin, China, and to evaluate the possible health risks to local population through foodchain. Results show that the most significantly contaminated soils occurred upstream at SCH where Cd, Cu and As concentrations exceeded maximum allowable concentrations for Chinese agricultural soil. Further downstream the degree of contamination semi-systematically decreased in concentrations of metal. Generally, the leafy vegetables were more heavily contaminated than non-leafy vegetables. Chinese cabbage is the most severely contaminated, the concentrations of Cd exceeded the maximum permit levels (0.05 mg/kg) by 4.5 times. Bio-accumulate factor also shows that an entry of Cd to food chain plants is the greatest potential. Furthermore, the estimated daily intake amounts of the considered toxic elements (Cd, Pb and Cu) from the vegetables grown at SCH and BWA and DWA have exceeded the recommended dietary allowance levels. Thus, the vegetables grown in three villages above, which affected by Baiyin mining and smelting have a health hazard for human consumption. | LI Yu WANG Yan-bin GOU Xin SU Yi-bing WANG Gang | 2006 | Journal of Environmental Sciences2006，18，6： | 84 |
| 2 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 3 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 4 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 5 | Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma:A literature review显示文摘Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum α-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first. | Jiann-Sheng Su Yu-Tso Chen Ren-Ching Wang Chun-Ying Wu Shou-Wu Lee Teng-Yu Lee | 2013 | World Journal of Gastroenterology2013，19，3： | 75 |
| 6 | Composition Modeling and Equivalence of an Integrated Power Generation System of Wind, Photovoltaic and Energy Storage Unit显示文摘利用间接组合建模的方法,在建立典型的双馈风机、光伏发电单元和储能单元的装置级机电暂态模型基础上,采用等值方法建立三者电站级的机电暂态模型,最终通过组合建模得到了风光储联合发电系统的机电暂态模型。在大型电力系统分析软件包的PSD-BPA暂态稳定程序中实现了风光储联合发电系统的仿真功能,通过典型算例和张北"国家风光储输示范工程"的仿真分析验证了模型的正确性,为风光储联合发电系统的并网研究提供了分析手段。 | WANG Haohuai TANG Yong HOU Junxian ZOU Jiangfeng LIANGShuang SU Feng | 2011 | 中国电机工程学报2011，31，34： | 66 |
| 7 | High Prevalence of Gestational Diabetes Mellitus in Beijing: Effect of Maternal Birth Weight and Other Risk Factors显示文摘 | Wei-Wei Zhu Hui-Xia Yang Chen Wang Ri-Na Su Hui Feng Anil Kapur | 2017 | Chinese Medical Journal2017，，9： | 61 |
| 8 | The Beishan underground research laboratory for geological disposal of high-level radioactive waste in China:Planning, site selection,site characterization and in situ tests显示文摘With the rapid development of nuclear power in China, the disposal of high-level radioactive waste(HLW) has become an important issue for nuclear safety and environmental protection. Deep geological disposal is internationally accepted as a feasible and safe way to dispose of HLW, and underground research laboratories(URLs) play an important and multi-faceted role in the development of HLW repositories. This paper introduces the overall planning and the latest progress for China's URL. On the basis of the proposed strategy to build an area-specific URL in combination with a comprehensive evaluation of the site selection results obtained during the last 33 years, the Xinchang site in the Beishan area,located in Gansu Province of northwestern China, has been selected as the final site for China's first URL built in granite. In the process of characterizing the Xinchang URL site, a series of investigations,including borehole drilling,geological mapping, geophysical surveying,hydraulic testing and in situ stress measurements, has been conducted. The investigation results indicate that the geological,hydrogeological, engineering geological and geochemical conditions of the Xinchang site are very suitable for URL construction. Meanwhile, to validate and develop construction technologies for the Beishan URL, the Beishan exploration tunnel(BET), which is a 50-m-deep facility in the Jiujing sub-area, has been constructed and several in situ tests, such as drill-and-blast tests, characterization of the excavation damaged zone(EDZ), and long-term deformation monitoring of surrounding rocks, have been performed in the BET. The methodologies and technologies established in the BET will serve for URL construction.According to the achievements of the characterization of the URL site, a preliminary design of the URL with a maximum depth of 560 m is proposed and necessary in situ tests in the URL are planned. | Ju Wang Liang Chen Rui Su Xingguang Zhao | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 62 |
| 9 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 10 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 11 | Glycemic variability in insulin treated type 2 diabetes with well-controlled hemoglobin Alc and its response to further treatment with acarbose显示文摘背景 Glycemic 可变性,一个 HbA1c 独立的风险因素,在糖尿病的复杂并发症的发展比持续多糖症有更有害的效果。这研究与 acarbose.Methods 在两次每日的 premixed 胰岛素治疗的持续时间和进一步的治疗的效果与HbA1c6.5%在类型 2 糖尿病 mellitus ( T2DM )分析了 glycemic 可变性的特征使用了 premixed 胰岛素类似物的 86 个 T2DM 病人(胰岛素 aspart 30 )两次每日、有的HbA1c 6.5%并且 20 控制了有正常葡萄糖规定( NGR )的题目用监视的连续葡萄糖( CGM )被监视系统。glycemic 旅行(魔术师) 的吝啬的振幅,每日的差别(MODD ) 的平均数被用于估计 intra 天,内部天的 glycemic 可变性。低血糖症在 CGM 被定义为葡萄糖水平 3.9 mmol/L 至少 15 分钟。根据魔术师的参考价值, T2DM 病人被分类进二个组: 有魔术师 3.4 mmol/L (L 魔术师) 和高度的 Iow 魔术师组 -- 有魔术师 3.4 mmol/L (H 魔术师) 的魔术师组。H 魔术师组与 acarbose 接受了进一步的治疗 2 个星期并且第二次在第一 CGM 以后与 CGM system.Results 被监视,有的 L 魔术师组 41 个盒子,和 H 魔术师组有 45 个盒子。T2DM 组的魔术师和 MODD 都比有 NGR (P0.01 ) 的题目的那些高。(n=11 )百分之 24 在 H 魔术师组有 13 个血糖过低的事件的一个总数, 13 个事件中的 10 个发生在夜里,(n=2 ) 同时, 5% 在 L 魔术师组有 2 个血糖过低的事件的一个总数,它也发生在夜里(血糖过低的事件:24% 对 5% , x2=6.40, P0.01 ).MAGE 价值与低血糖症价值和 2 小时的饭后的血浆葡萄糖价值被相关(r=0.32 并且 0.26,分别地 P0.05 ) 。在进一步的 acarbose 治疗以后并且第二,在 H 魔术师的价值组织的 CGM,魔术师和 MODD 都显著地被减少(40% , P0.01,并且 15% , P0.05,分别地) ,但是与 NGR (P0.05 ) 仍然保持比在这些题目高;(n=1 )2% 有 1 个血糖过低的事件的一个总数,发生显著地减少了(2% 对 24%,2=9.61, P 0.01 ).Conclusions CGM 系统能在胰岛素处理的持续时间与控制得好的 HbA1c 检测 glycemic 可变性和 T2DM 的无征状的血糖过低的事件。与 acarbose 罐头公寓 glycemic 可变性和减少两次每日的 premixed 胰岛素的联合治疗血糖过低的事件。 | SU Jian-bin WANG Xue-qin CHEN Jin-feng WU Gang JIN Yan | 2011 | Chinese Medical Journal2011，，1： | 41 |
| 12 | Shear-wave splitting beneath Yunnan area of Southwest China显示文摘Systematic analyses of seismic data recorded by the Yunnan regional seismograph network reveal significant crustal and upper mantle anisotropy.Splitting of the S phase of local earthquakes and teleseismic SKS,PKS,and SKKS phases indicates time-delays from 1.60 ms/km to 2.30 ms/km in the crust,and from 0.55 s to 1.65 s in the upper mantle which corresponds to an anisotropic layer with a thickness about between 55-165 km.The polarization orientations of fast shear waves in the crust are complicated with a predominantly north-south direction,and the mantle anisotropy has a nearly west-east direction.Our results show different deformation styles and mechanisms exist between the crust and upper mantle. | Yutao Shi Yuan Gao Youjin Su Qiong Wang | 2012 | Earthquake Science2012，25，1： | 46 |
| 13 | Randomized controlled trial of uncut Roux-en-Y vs Billroth Ⅱ reconstruction after distal gastrectomy for gastric cancer: Which technique is better for avoiding biliary reflux and gastritis?显示文摘AIM To identify which technique is better for avoiding biliary reflux and gastritis between uncut Roux-en-Y and Billroth Ⅱ reconstruction. METHODS A total of 158 patients who underwent laparoscopyassisted distal gastrectomy for gastric cancer at the First Hospital of Jilin University(Changchun, China) between February 2015 and February 2016 were randomized into two groups: uncut Roux-en-Y(group U) and Billroth II group(group B). Postoperative complications and relevant clinical data were compared between the two groups. RESULTS According to the randomization table, each group included 79 patients. There was no significant difference in postoperative complications between groups U and B(7.6% vs 10.1%, P = 0.576). During the postoperative period, group U stomach p H values were lower than 7 and group B p H values were higher than 7. After 1 year of follow-up, group B presented a higher incidence of biliary reflux and alkaline gastritis. However, histopathology did not show a significant difference in gastritis diagnosis(P = 0.278), and the amount of residual food and gain of weight between the groups were also not significantly different. At 3 mo there was no evidence of partial recanalization of uncut staple line, but at 1 year the incidence was 13%. CONCLUSION Compared with Billroth II reconstruction, uncut Rouxen-Y reconstruction is secure and feasible, and can effectively reduce the incidence of alkaline reflux, residual gastritis, and heartburn. Despite the incidence of recanalization, uncut Roux-en-Y should be widely applied. | Dong Yang Liang He Wei-Hua Tong Zhi-Fang Jia Tong-Rong Su Quan Wang | 2017 | World Journal of Gastroenterology2017，23，34： | 43 |
| 14 | Effects of field application of phosphate fertilizers on the availability and uptake of lead, zinc and cadmium by cabbage (Brassica chinensis L.) in a mining tailing contaminated soil显示文摘A field trial was conducted to evaluate the reduction of bioavailability of heavy metals including lead (Pb), zinc (Zn) and cadmium (Cd) in a soil contaminated by mining tailings in Shaoxing, Zhejiang, China. Three commercial phosphate (P) fertilizers including phosphate rock (PR), calcium magnesium phosphate (CMP), and single superphosphate (SSP) were applied to the plot at three P application rates, 50, 300, and 500 g/m2 with 9 treatments and control (CK). Plants, water soluble and exchangeable (WE) extraction procedure and modified toxicity characteristic leaching procedure (TCLP) were employed. It was found that the addition of all three P fertilizers significantly decreased WE Pb (22.0%-81.4%), Cd (1.5%-30.7%) and Zn (11.7%-75.3%, exception of SSP treatments with no significant difference) and TCLP Pb concentration (27.1%-71.2%), compared with the control, leading to reduced uptake of Pb (16.0%-58.0%), Cd (16.5%-66.9%) and Zn (1.2%-73.2%) by cabbage (Brassica chinensis L.). It was suggested that P fertilizers induced immobilization of heavy metals such as Pb, Cd, and Zn. CMP provided the most effective method of reducing metal toxicity, mobility, and phytoavailability. At the P application rate of 300 g/m2, CMP would be cost-effective to decrease WE Pb, Zn, and Cd concentration from 666 to 137 mg/kg, from 31.2 to 8.71 mg/kg, and from 1.69 to 1.36 mg/kg, respectively. SSP was more effective in reducing Pb bioavailability than PR but had variable effects on Zn bioavailability. Cd uptake by cabbage was negatively correlated with soil pH rather than with WE or TCLP, indicating that Cd uptake by cabbage was a complex process. It should be careful to evaluate the impact of phosphate application on Cd availability in soil. | Biling WANG Qiufeng SU | 2008 | Journal of Environmental Sciences2008，20，9： | 39 |
| 15 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 16 | The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China显示文摘This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous),and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the lateAchaean-formed cratonic lithosphere had been significantly reworked. | DENG Jinfu, SU Shangguo, MO Xuanxue, ZHAO Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, ZHAO Hailing, LUO Zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 35 |
| 17 | Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis显示文摘背景人参皂甙是从人参提取的主要部件,并且人参皂甙 Rg3 是最重要的部分之一。人参皂甙 Rg3 被发现了禁止几种肿瘤生长和转移。现在的学习被承担在人的卵巢的癌症转移和试验性的肺转移卵巢的癌症 SKOV-3 建模的可能的 mechanism.Methods 上调查人参皂甙 Rg3 的效果,导致肿瘤的 angiogenesis 的试金被用来在肿瘤转移和 angiogenesis 上观察 Rg3 的禁止的效果。在 vitro 的 SKOV-3 房间的侵略能力上的 Rg3 的效果被 Boyden 房间检测,并且染色的 immunofluorescence 被用来认出矩阵 metalloproteinase 的表示( MMP-9 ) 9 卵巢的癌症在在试验性的肺转移的 SKOV-3 cells.Results 当模特儿,在肺和向在每个人参皂甙 Rg3 组的肿瘤团面向的容器的肿瘤殖民地的数字,比控制的低组。在有人参皂甙 Rg3.Conclusions 人参皂甙 Rg3 的治疗能显著地禁止卵巢的癌症的转移以后,侵略能力和 SKOV-3 房间的 MMP-9 表示显著地减少了。禁止的效果部分由于导致肿瘤的 angiogenesis 的抑制和侵略能力和 SKOV-3 房间的 MMP-9 表示的减少。 | XU Tian-min CUI Man-hua XIN Ying GU Li-ping JIANG Xin SU Man-man WANG Ding-ding WANG Wen-jia | 2008 | Chinese Medical Journal2008，，15： | 35 |
| 18 | Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study显示文摘背景尽管在中国的死亡的第一个领先的原因是恶意的瘤(死亡, 374.1 每 100000 人年),因为关于学习试图在 PBT.Methods 的流行上报导一个全面评价的大脑 tumors.This 的流行病的特征有一些很好记录的报告,保健系统上的主要大脑肿瘤( PBT )的完整的影响完全没被描述 multicenter 大脑肿瘤( MCSBT )上的代表性的学习在里面中国在五地区性的 c 被开始59 岁;女性: 45 岁) .Conclusions 年龄标准化了 PBT 的流行是 22.52 每 100 000 (95% CI , 13.22~31.82 )为所有人口, 17.64 每 100 000 (95% CI , 9.41~25.87 )为人,和 27.94 同等 100 000 (95% CI , 17.58~38.30 )为有 PBT.Our 流行的 304 954 个案例的一张估计的人口估计的到中国产出的 2010 人口的 women.Age 标准化提供计划护理服务并且为 surviving.In 开发编程的策略的一个保守基础未来,它将是 | JIANG Tao TANG Gen-fu LIN Yi PENG Xiao-xia ZHANG Xiao ZHAI Xiu-wei PENG Xiang YANG Jin-qing HUANG Hong-er WU Nai-feng CHEN Xiao-jun XING Hou-xun SU Tong-yong WANG Zhong-cheng | 2011 | Chinese Medical Journal2011，，17： | 40 |
| 19 | Discovery of the eclogite and its petrography in the Northern Dabie Mountain显示文摘Eclogite from the Northern Dabie Mountain is a new finding by the authors. These eclogites in foliated perdotite are enveloped by banded gneiss and occur in the mafic-ultramafic rock belt. They are mainly composed of omphacite, garnet, diopside, orthopyroxene, amphibole, plagioclase and magnetite, and a small amount of rutile, spinel, olivin and 鏾rundum. The mineral association of peak metamorphism of the eclogite is omphacite+garnet+rutile. The existence of eclogite in the Northern Dabie Mountain implies that there was an eclogitic metamorphism prior to the granulitic facies one in the mafic-ultramafic rock belt. | XU Shutong LIU Yican SU Wen WANG Rucheng JIANG Laili WU Weiping | 2000 | Chinese Science Bulletin2000，45，3： | 39 |
| 20 | Inhibition of Dual Specific Oncolytic Adenovirus on Esophageal Cancer via Activation of Caspases by a Mitochondrial-dependent Pathway显示文摘We investigated the anti-tumor effects of dual cancer specific-oncolytic adenovirus Ad-VP on esophageal cancer(EC).The anti-tumor activity of Ad-VP was compared with that of the control recombinant adenoviruses(Ad-GP,Ad-Apoptin,Ad-EGFP) in human esophageal cancer cell EC-109 and human normal liver cell L02 in vitro.In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays,the growth of EC-109 cells was slightly inhibited by Ad-GP,Ad-Apoptin and Ad-EGFP.However,Ad-VP induced a significant cytotoxic effect.Infection of EC-109 cells with Ad-VP resulted in a significant induction of apoptosis of them in vitro,detected by 4',6-diamidino-2-phenylindole(DAPI) or acridine orange and ethidium bromide staining.The results of Western blot and flow cytometric assay indicate the loss of mitochondrial membrane potential(ΔΨ m),the release of cytochrome c and the activation of caspase-3,6 and 7 in Ad-VP infected EC-109 cells.In contrast,all these assays show almost no effects of the recombinant adenoviruses on L02 cells.These results demonstrate that the treatment of tumors with Ad-VP selectively inhibits tumor growth and induces apoptosis of esophageal cancer cells.Ad-VP may provide a novel and powerful strategy for cancer gene therapy. | SU Jia-qiang CHI Bao-rong LI Xiao LIU Lei LIU Li-ming QI Yan-xin WANG Zhuo-yue JIN Ning-yi | 2012 | Chemical Research in Chinese Universities2012，28，3： | 38 |
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