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| 1 | Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease显示文摘AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular disease.METHODS:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men and women who were recruited from a health check-up program.NAFLD was diagnosed by abdominal ultrasonography.The metabolic syndrome(MS)was defined according to the modified National Cholesterol Education Program(NCEP)ATP Ⅲ criteria.Five years after the baseline evaluations,the incidence of cardiovascular disease was assessed by a self-administered questionnaire.RESULTS:Among 1221 participants available for outcome analyses,the incidence of cardiovascular disease was higher in 231 subjects with NAFLD at baseline(5 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage)than 990 subjects without NAFLD(3 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage).Multivariate analyses indicated that NAFLD was a predictor of cardiovascular disease independent of conventional risk factors(odds ratio 4.12,95% CI,1.58 to 10.75,P = 0.004).MS was alsoindependently associated with cardiovascular events.But simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NAFLD but not MS retained a statistically significant correlation with cardiovascular disease.CONCLUSION:Although both of them were predictors of cardiovascular disease,NAFLD but not MS retained a statistically significant correlation with cardiovascular disease in a multivariate model.NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS. | Masahide Hamaguchi Takao Kojima Noriyuki Takeda Chisato Nagata Jun Takeda Hiroshi Sarui Yutaka Kawahito Naohisa Yoshida Atsushi Suetsugu Takahiro Kato Junichi Okuda Kazunori Ida Toshikazu Yoshikawa | 2007 | World Journal of Gastroenterology2007，13，10： | 55 |
| 2 | Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation显示文摘Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used immunosuppressive agents for the prevention of post-transplantation rejection and have improved 1-year graft survival rates by up to 90%. However, CNIs can induce severe reactions, such as acute or chronic allograft nephropathy, hypertension, and neurotoxicity. Because CNIs have varied bioavailabilities, narrow therapeutic ranges, and individual propensities for toxic effects, therapeutic drug monitoring is necessary for all CNIs. Identifying the genetic polymorphisms in drug-metabolizing enzymes will help to determine personalized dosage regimens for CNIs, as CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp, MDR1). CNIs are often concomitantly administered with voriconazole or proton pump inhibitors (PPIs), giving rise to drug interaction problems. Voriconazole and PPIs can increase the blood concentrations of CNIs, and both are primarily metabolized by CYP2C19. Thus, it is expected that interactions between CNIs and voriconazole or PPI would be affected by CYP2C19 and CYP3A5 polymorphisms. CNI-induced acute kidney injury (AKI) is a serious complication of transplantations. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are noninvasive urinary biomarkers that are believed to be highly sensitive to CNI-induced AKI. In this article, we review the adverse events and pharmacokinetics of CNIs and the biomarkers related to CNIs, including CYP3A5, CYP2C19, MDR1, NGAL, and KIM-1. We hope that these data will help to identify the optimal biomarkers for monitoring CNI-based immunosuppressive therapy after organ transplantation. | Rao Fu Soichiro Tajima Kimitaka Suetsugu Hiroyuki Watanabe Nobuaki Egashira Satohiro Masuda | 2019 | Acta Pharmacologica Sinica2019，40，2： | 10 |
| 3 | 阿司匹林哮喘显示文摘 | 童茂荣 夏锡荣 Susumu Suetsugu | 1999 | 中华结核和呼吸杂志1999，22，11： | 7 |
| 4 | 阻塞性睡眠呼吸暂停患者的上气道狭窄与头姿变化显示文摘探讨阻塞性睡眠呼吸暂停(Obstructivesleepapnea,OSA)患者上气道狭窄的程度、头姿改变情况,以及这些形态学指标与病理生理学参数之间的关系。研究对象为86例男性OSA患者及37名健康男性。经整夜多导睡眠仪检查诊断或排除OSA;采用数字化技术摄取受试者头颅侧位片,并用NIHImage软件测定上气道口径、面积及头姿指标共15项。OSA患者各水平上气道前后径均显著小于对照组;经年龄及身高体重指数校正后,上述结果不变。重症OSA患者呈显著头颅前倾。头姿变化指标与呼吸暂停指数及多个水平的气道前后径呈显著相关。亚洲人种OSA患者存在明显及广泛的上气道狭窄;随OSA程度加重及上气道阻塞程度加重。 | 童茂荣 乐玮 曹鄂洪 夏锡荣 Hiroki Sakakibara Susumu Suetsugu | 1998 | 南京大学学报(自然科学版)1998，34，5： | 7 |
| 5 | Characterization of CD133 + hepatocellular carcinoma cells as cancer stem/progenitor cells显示文摘 | Atsushi Suetsugu Masahito Nagaki Hitomi Aoki Tsutomu Motohashi Takahiro Kunisada Hisataka Moriwaki | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 4 |
| 6 | Characterization of CD133+hepatocellular carcinoma cells as cancer stem/progenitor cells显示文摘 | Suetsugu A Nagaki M Aoki H | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 7 | Plant Organelle Positioning 显示文摘 | MASAMITSU WADA NORIYUKI SUETSUGU | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
| 8 | Rac-WAVE2 signaling is involved in the invasive and meta-static phenotypes of murine melanoma cells 显示文摘 | KURISU S SUETSUGU S YAMAZAKI D | 2005 | Onco-gene2005，24，8： | 1 |
| 9 | Preparation and Mechanical Properties of Calcium Phosphate/Copoly-L-Lactide Composites 显示文摘 | Kikuchi M Suetsugu Y Tanaka J | 1997 | Journal of Materials Science Materials in Medicine1997，8，6： | 1 |
| 10 | Influence of Helicobacter pylori infection and cetraxate on gastric mucosal blood flow during healing of endoscopic mucosal resection-induced ulcers 显示文摘 | Adachi K Suetsugu H Moriyama N | 2001 | J Gastro- enterol Hepatol2001，16，11： | 1 |
| 11 | Small low-density lipoprotein and small low-density lipoproteirdtotal low-density lipoprotein are closely associated with intima-media thickness of the carotid artery in Type 2 diabetic patients 显示文摘 | INUKAI T YAMAMOTO R SUETSUGU M | 2005 | J Diabetes Complications2005，19，5： | 1 |
| 12 | Characterization of CD133 + hepatocellular carcinoma cells as cancer stem/progenitor cells 显示文摘 | Suetsugu A Nagaki M Aoki H | 2006 | Biochemical and Biophysical Research Communications2006，351，4： | 1 |
| 13 | Arabidopsis NPL1:a pho-totropin homolog controlling the chloroplast high-light avoidance response显示文摘 | Kagawa T Sakai T Suetsugu N | | 0，，5511： | 1 |
| 14 | Effect of rebamipide on prostaglandin EP4 receptor gene expression in rat gastric mueosa 显示文摘 | Suetsugu H Ishihara S Moriyama N | 2000 | J Lab Clin Med2000，136，1： | 1 |
| 15 | Retinol-binding protein 4 levels and clinical features of type 2 diabetes patients显示文摘 | Takebayashi K Suetsugu M Wakabayashi S | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 16 | Study of autonomous mobile sensing system for localization of odor so urce using gas sensors and anemometric sensors显示文摘 | ISHIDA H SUETSUGU K NAKAMOTO T | 1994 | Sensors and Actuators A1994，45，2： | 1 |
| 17 | A case of rapidly growing inflammatory myofibroblastic tumor in the lung 显示文摘 | Suetsugu S Yamamoto H Izumi M | 2009 | Nihon Kokyuki Gakkai Zasshi2009，47，12： | 1 |
| 18 | Tran- scriptome analysis of neuropeptides and G-protein coupled receptors (GPCRs) for neuropeptides in the brown planthop- per Nilaparvata lugens显示文摘 | TANAKA Y SUETSUGU Y YAMAMOTO K | 2014 | Peptides2014，53，： | 1 |
| 19 | Design equations for sub-optimum operation of Class E amplifier with nonlinear shunt capacitance 显示文摘 | SUETSUGU T KAZIMIERCZUK M K | 2004 | IEEE International Symposium on Circuits and Systems2004，5，995： | 1 |
| 20 | Imageable fluorescent me- tastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens显示文摘 | Suetsugu A Kaz M Fleming J | 2012 | Anti- cancer Res2012，32，4： | 1 |
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