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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Study on the risk factors of lymphatic metastasis and the indications of less invasive operations in early gastric cancer显示文摘INTRODUCTIONThe principle of surgical treatment for gastric cancer is theradical resectioning although the suitable resetting range fordifferent cases of gastric cancer is still being arguedupon.However,the diagnostic accuracy of | Jiang BJ Sun RX Lin H Gao YF | 2000 | World Journal of Gastroenterology2000，6，4： | 15 |
| 3 | Self-attention transfer networks for speech emotion recognition显示文摘Background A crucial element of human-machine interaction,the automatic detection of emotional states from human speech has long been regarded as a challenging task for machine learning models.One vital challenge in speech emotion recognition(SER)is learning robust and discriminative representations from speech.Although machine learning methods have been widely applied in SER research,the inadequate amount of available annotated data has become a bottleneck impeding the extended application of such techniques(e.g.,deep neural networks).To address this issue,we present a deep learning method that combines knowledge transfer and self-attention for SER tasks.Herein,we apply the log-Mel spectrogram with deltas and delta-deltas as inputs.Moreover,given that emotions are time dependent,we apply temporal convolutional neural networks to model the variations in emotions.We further introduce an attention transfer mechanism,which is based on a self-attention algorithm to learn long-term dependencies.The self-attention transfer network(SATN)in our proposed approach takes advantage of attention transfer to learn attention from speech recognition,followed by transferring this knowledge into SER.An evaluation built on Interactive Emotional Dyadic Motion Capture(IEMOCAP)dataset demonstrates the effectiveness of the proposed model. | Ziping ZHAO Keru Wang Zhongtian BAO Zixing ZHANG Nicholas CUMMINS Shihuang SUN Haishuai WANG Jianhua TAO Björn WSCHULLER | 2021 | Virtual Reality & Intelligent Hardware2021，3，1： | 3 |
| 4 | ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids 显示文摘 | Hirschberg H Sun CH Tromberg BJ | 2002 | J Neurooncol2002，57，1： | 1 |
| 5 | Effects of different forms of nitrogen addition on microbial extracellular enzyme activity in temperate grassland soil显示文摘Background:Nitrogen(N)deposition alters litter decomposition and soil carbon(C)sequestration by influencing the microbial community and its enzyme activity.Natural atmospheric N deposition comprises of inorganic N(IN)and organic N(ON)compounds.However,most studies have focused on IN and its effect on soil C cycling,whereas the effect of ON on microbial enzyme activity is poorly understood.Here we studied the effects of different forms of externally supplied N on soil enzyme activities related to decomposition in a temperate steppe.Ammonium nitrate was chosen as IN source,whereas urea and glycine were chosen as ON sources.Different ratios of IN to ON(Control,10:0,7:3,5:5,3:7,and 0:10)were mixed with equal total amounts of N and then used to fertilize the grassland soils for 6 years.Results:Our results show that IN deposition inhibited lignin-degrading enzyme activity,such as phenol oxidase(POX)and peroxidase(PER),which may restrain decomposition and thus induce accumulation of recalcitrant organic C in grassland soils.By contrast,deposition of ON and mixed ON and IN enhanced most of the C-degrading enzyme activities,which may promote the organic matter decomposition in grassland soils.In addition,theβ-N-acetyl-glucosaminidase(NAG)activity was remarkably stimulated by fertilization with both IN and ON,maybe because of the elevated N availability and the lack of N limitation after long-term N fertilization at the grassland site.Meanwhile,differences in soil pH,soil dissolved organic carbon(DOC),and microbial biomass partially explained the differential effects on soil enzyme activity under different forms of N treatments.Conclusions:Our results emphasize the importance of organic N deposition in controlling soil processes,which are regulated by microbial enzyme activities,and may consequently change the ecological effect of N deposition.Thus,more ON deposition may promote the decomposition of soil organic matter thus converting C sequestration in grassland soils into a C source. | Lili Dong Björn Berg Weiping Gu Zhengwen Wang Tao Sun | 2022 | Ecological Processes2022，11，1： | 1 |
| 6 | Effects of combined photodynamic therapy and ionizing radiation on human glioma spheroids 显示文摘 | Madsen SJ Sun CH Tromberg BJ | 2002 | Photochem Photobiol2002，76，： | 1 |
| 7 | Effects of dietary mixtures of amino acids on fetal growth and fetal amino acids pools in experimental maternal phenylketonuria显示文摘 | Austic RE Sun CL Strupp BJ | 1999 | Am J Clin Nutr1999，69，4： | 1 |
| 8 | A new approach to ovarian reserve, testing 显示文摘 | Sun W Stegmann BJ Henne MA | 2008 | Fertil Steri12008，90，6： | 1 |
| 9 | Effect of ET-1 on arteries and venae in vivo显示文摘 | Zuleica B Guan BJ SUN M | 1989 | J Cardiovasc Pharmacol1989，13，： | 1 |
| 10 | Microsatellitevariability and heterozygote excess in Elymus trachycauluspopulations from British Columbia in Canada显示文摘 | Stevens Laci Salomon Bj?rn Sun Genlou | 2007 | BiochemicalSystematics and Ecology2007，35，： | 1 |
| 11 | Subfamily I Treponema pallidurn repeat protein family:sequence variation and immunity显示文摘 | Sun ES BJ Molini LK Barrett | 2004 | Microbes Infec2004，6，8： | 1 |
| 12 | Hand, foot, and mouth disease in China, 2008-12: an epidemiological study 显示文摘 | Xing W Liao Q Viboud C Zhang J Sun J Wu JT Chang Z Liu F Fang VJ Zheng Y Cowling BJ Varma JK Farrar JJ Leung GM Yu H | 2014 | Lancet Infect Dis2014，14，4： | 1 |
| 13 | Stent-based gene therapy显示文摘 | Feldman MD Sun B Koci BJ | 2000 | J Long Term Eft Med Implants2000，10，12： | 1 |
| 14 | Hand, foot, and mouth disease in China, 2008-12: an epidemiological study 显示文摘 | Xing W Liao Q Viboud C Zhang J Sun J Wu JT Chang Z Liu F Fang VJ Zheng Y Cowling BJ Varma JK Farrar JJ Leung GM Yu H | 2014 | Lancet Infect Dis2014，14，4： | 1 |
| 15 | Stent based gene therapy显示文摘 | Feldman MD Sun B Koci BJ | 2000 | J Long Term Eff Med Implants2000，10，12： | 1 |
| 16 | Effect of ET - 1 on arteries and venae in vivo显示文摘 | Zuleica B Guan BJ SUN M | 1989 | J Cardiovascu Phamacol1989，13，： | 1 |
| 17 | Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids显示文摘 | Hirschberg H Sun CH Tromberg BJ | 2004 | J Neurooncol2004，70，： | 1 |
| 18 | Imaging characteristics of ischemic strokes related to patent foramen ovale显示文摘 | Kim BJ Sohn H Sun BJ | 2013 | Stroke2013，44，： | 1 |
| 19 | Modulation of reactive oxygen species in pancreatic cancer 显示文摘 | Teoh ML Sun W Smith BJ | 2007 | Clin Cancer Res2007，13，24： | 1 |
| 20 | Bone marrow mesenchymal stem cell from chronic hepatitis B patients differentiation into hepatocytelike cells显示文摘 | Fan BJ Piao YF Sun XY | | 0，，02： | 1 |
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