|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 2 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 3 | Dioxygen Affinity and Catalytic Performance of Bis-(furaldehyde) Schiff Bases Co(II) Complexes in Cyclohexene Oxidation显示文摘Oxygenation constants and thermodynamic parameters DHo and DSo of cobalt (II) complexes with bis-(furaldehyde) Schiff bases (1, 2, 3, 4)were obtained by mearsuring saturated dioxygen uptake of these complexes in pyridine at different temperature. These complexes could activate molecular oxygen and were used as catalysts in cyclohexene oxidation. The influence of ligand structure on the dioxygen affinity and catalytic activity of the complexes were discussed. | Sun, B Chen, JR Hu, JY Li, XJ | 2001 | Chinese Chemical Letters2001，12，11： | 4 |
| 4 | The most appropriate category of metastatic lymph nodes to evaluate overall survival of gastric cancer following curative resection显示文摘 | Deng JY Liang H Sun D | | 0，，05： | 2 |
| 5 | Lead-promoted Barbier-type reaction of aldehydes with propargyl bromides in aqueous media显示文摘This paper reports that the reaction of the propargyl bromides with aldehydes promoted by powdered lead in aqueous media.The selectivity and possible mechanism of these reactions are discussed.The yields of products for reaction of propargyl bromide are 31~71%.The ratios of al-lenyl alcohol and homopropargyl alcohol are 1:1.5 to 1:3.The product for reaction of phenyl propargyl bromide is allenyl alcohol and the yields are 52~84%. | Zhou, JY Sun, GF Zhang, MF Jia, Y Wu, SH | 1997 | Chinese Journal of Chemistry1997，15，4： | 2 |
| 6 | Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Li YH Wang CY Sun JY | 2005 | Analytica Chimica Acta2005，550，12： | 1 |
| 7 | Overexpression of Bcl-2 blocks TNF-related apoptosis-inducing ligand (TRAIL)induced apoptosis in human lung cancer cells显示文摘 | Sun SY Yue P Zhou JY | 2001 | Biochem Biophys Res Commun2001，280，： | 1 |
| 8 | Indeterminate observations (liver imaging reporting and data system category 3) on MRI in the cir- rhotic liver fate and clinical implications显示文摘 | Choi JY Cho HC Sun M | 2013 | AJR2013，201，5： | 1 |
| 9 | The most appropriate category of metastatic lymph nodes to evaluate overall survival of gastric cancer following curative resection 显示文摘 | Deng JY Liang H Sun D etal | 2008 | J Surg Oncol2008，98，5： | 1 |
| 10 | In-vitro antitumor activity evaluation of hyperforin derivatives显示文摘 | Sun F Liu JY He F Liu Z Wang R Wang DM | 2011 | J Asian Nat Prod Res2011，13，8： | 1 |
| 11 | Analysis of beta- lactamase in mult-resistant Pseudomonas aeruginosa 显示文摘 | JIANG X F HONG X H SUN JY | 2002 | Chin J Microbiol Immunol2002，22，： | 1 |
| 12 | Overexpression of BCL2 blocks TNF-related-apoptosis-inducing ligand(TRAIL)-induced apoptosis in human lung cancer cells显示文摘 | Sun SY Yue P Zhou JY | 2001 | Biochem Biophys Res Commun2001，280，3： | 1 |
| 13 | Hydrolysis of lignocellulosic materials for ethanol production: a review显示文摘 | Sun Y Cheng JY | 2002 | Bioresource Technology2002，83，1： | 1 |
| 14 | Proteomics analysis of differentially expressed metastasis-associated proteins in adenoid cystic carcino- ma cell lines of human salivary gland 显示文摘 | An J Sun JY Yuan Q | 2004 | Oral Oncol2004，40，4： | 1 |
| 15 | Increased Th17 cells con- tribute to disease progression in patients with HBV -associated liver cirrhosis显示文摘 | Sun HQ Zhang JY Zhang H | 2012 | Viral Hepat2012，19，6： | 1 |
| 16 | Effect of hepatocyte growth factor encapsulated in targeted liposomes on liver cirrhosis显示文摘 | Li F Sun JY Wang JY | 2008 | J Control Release2008，131，1： | 1 |
| 17 | Sanguinarine suppresses prostatetumor growth and inhibits survivinexpression显示文摘 | Sun M Lou W Chun JY et a/ | 2010 | Genes Cancer2010，1，3： | 1 |
| 18 | Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts 显示文摘 | Tuan TL Zhu JY Sun B | 1996 | J Investiga Dermatol1996，106，5： | 1 |
| 19 | Antiviral activity of daphnore- tin isolated from Wikstroemia indica 显示文摘 | Ho WS Xue JY Sun SS | 2010 | Phytother Res2010，24，5： | 1 |
| 20 | Pharmacological studies of the large - scaled purified genistein from Huaijiao ( Sophora japonica-Leguminosae ) on anti - osteoporosis 显示文摘 | Wang ZL Sun JY Wang DN | 2007 | Phytomedicine2007，13，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员