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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Measurement of liver volume and its clinical significance in cirrhotic portal hypertensive patients显示文摘 | Zhu JY Leng XS Dong N Qi GY Du RY | 1999 | World Journal of Gastroenterology1999，5，6： | 10 |
| 3 | Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension显示文摘INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) with | Zhu JY Leng XS Wang D Du RY | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 4 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 5 | Mineralogical alteration of thermally treated siderite in air: Mossbauer spectroscopy results显示文摘Mineralogical alternation of thermally treated siderite in air atmosphere has been systematically analyzed by Mossbauer effects. It was preliminarily estimated from the area of sub-spectra that 4% , 39% and 62% of magnetite were formed at 410℃, 490℃ and 510℃ respectively. After being incrementally heated at 530℃ the spectra consist of two sextets of Fe3O4. Sextet of γ-Fe2O3 with hyperfine field of 50T was observed at 550℃. Spectra at 580℃ | Pan, YX Zhu, RX Ping, JY | 1999 | Chinese Science Bulletin1999，44，18： | 2 |
| 6 | Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c(SRp30c)in prostate cancer cells显示文摘 | Zhu J Gong JY Goodman OB Jr | 2007 | Biochim Biophys Acta2007，1773，7： | 1 |
| 7 | Senescence of human fibroblasts induced by oncogenic Raf显示文摘 | Zhu JY Woods D McMahon M | 1998 | Genes & Development1998，12，19： | 1 |
| 8 | Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts显示文摘 | Liu JY Hu JH Zhu QG | 2007 | Int lmmunopharmacol2007，7，6： | 1 |
| 9 | A comparative qualitative histological analysis of tissue-engineered bone using bone marrow mesenchymal stem cells,alveolar bone cells,and periosteal cells显示文摘 | Choi BH Huh JY | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，101，2： | 1 |
| 10 | microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma显示文摘 | Imig J Motsch N Zhu JY | | 0，，05： | 1 |
| 11 | Effects of cytokine- induced killer cell treatment in colorectal cancer patients:a retrospective study 显示文摘 | ZHANG JY ZHU LJ ZHANG Q | 2014 | Biomed Pharmacother2014，68，6： | 1 |
| 12 | Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts 显示文摘 | Tuan TL Zhu JY Sun B | 1996 | J Investiga Dermatol1996，106，5： | 1 |
| 13 | Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas显示文摘 | Zhu JY Pfuhl T Motsch N | | 0，，07： | 1 |
| 14 | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2 -:H2O2 ratio and confers anoikis resistance to tumors显示文摘 | Zhu P Tan MJ Huang RL Tan CK Chong HC Pal M Lam CR Boukamp P Pan JY Tan SH Kersten S Li HY Ding JL Tan NS | | 0，，03： | 1 |
| 15 | Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis 显示文摘 | Fas SC Baumann S Zhu JY | 2006 | Blood2006，108，12： | 1 |
| 16 | Preconditioning rabbit cardiom yocytes role of PH, vascular protection ATPase and apoptosis 显示文摘 | Gottlieb R_A Gruol DL Zhu JY | 1996 | JCI in Inbest1996，97，4： | 1 |
| 17 | miRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes显示文摘 | Zhang YK Zhu WY He JY | 2012 | J Cancer Res Clin Oncol2012，138，10： | 1 |
| 18 | Effect of long-term mild hypothermia on patients with severe traumatic brain injury with 1 year follow up of 87 cases显示文摘 | Jiang JY Yu MK Zhu C | | 0，，04： | 1 |
| 19 | RhD-negative blood source management and clinical blood in ningbo city显示文摘 | Zhu XD Chen CS Zhang JY | 2006 | Modern Practical Medicine2006，17，74： | 1 |
| 20 | Weakly supervised histopathology cancer image segmentation and classification显示文摘 | Xu Y Zhu JY Chang EI | 2014 | Med Image Anal2014，18，3： | 1 |
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