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| 1 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 2 | High-efficiency white organic light emitting devices with three separate phosphorescent emission layers显示文摘 | Sun Yiru Forrest Stephen R | 2007 | Appl Phy Lett2007，91，26： | 1 |
| 3 | Management of singlet and triplet excitons for efficient white organic light-emitting devices 显示文摘 | Sun Yiru Noel C G Hiroshi K | 2006 | Nature2006，440，7086： | 1 |
| 4 | High-Efficiency White Organic Light Emitting Devices with Three Separate Phosphores- cent Emission Layers显示文摘 | SUN Yiru FORREST S R | 2007 | Applied Physics Letters2007，91，26： | 1 |
| 5 | High-efficiency white organic light emitting devices with three separate phosphorescent emission layers显示文摘 | Sun Yiru Forrest Stephen R | 2007 | Appl Phy Lett2007，91，26： | 1 |
| 6 | An efficient full dynamic group signature scheme over ring显示文摘The group signature scheme is an important primitive in cryptography,it allows members in a group to generate signatures anonymously on behalf of the whole group.In view of the practical application of such schemes,it is necessary to allow users’registration and revocation when necessary,which makes the construction of dynamic group signature schemes become a significant direction.On the basis of(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017),we present the first full dynamic group signature scheme over ring,and under the premise of ensuring security,the efficiency of the scheme is improved mainly from the following three aspects:the size of keys,the dynamic construction of a Merkle hash tree that used to record the information of registered users,and the reuse of the leaves in this tree.In addition,the public and secret keys of both group manager and trace manager are generated by a trusted third party,which prevents the situation that the two managers generate their respective public key and secret key maliciously.Compared with the counterpart of the scheme in(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017)over ring,the expected space complexity of the Merkle tree used in our work down almost by half,and the computational complexity of its update has been reduced by a notch because of the dynamic construction of the hash tree. | Yiru Sun Yanyan Liu Bo Wu | 2019 | Cybersecurity2019，2，1： | 0 |
| 7 | Concurrent non-malleable zero-knowledge and simultaneous resettable non-malleable zero-knowledge in constant rounds显示文摘Concurrent non-malleable zero-knowledge(CNMZK)considers the concurrent execution of zero-knowledge protocols in a setting even when adversaries can simultaneously corrupt multiple provers and verifiers.As far as we know,the round complexity of all the constructions of CNMZK arguments for NP is at least ω(log n).In this paper,we provide the first construction of a constant-round concurrent non-malleable zero-knowledge argument for every language in NP.Our protocol relies on the existence of families of collision-resistant hash functions,one-way permutations and indistinguishability obfuscators.As an additional contribution,we study the composition of two central notions in zero knowledge,the simultaneously resettable zero-knowledge and non-malleable zero-knowledge,which seemingly have stronger proved security guarantees.We give the first construction of a constant-round simultaneously-resettable non-malleable zero-knowledge.To the best of our knowledge,this is the first study to combine the two security concepts described above together in the zero-knowledge protocols. | Zhenbin Yan Yi Deng Yiru Sun | 2018 | Cybersecurity2018，1，1： | 0 |
| 8 | An efficient full dynamic group signature scheme over ring显示文摘The group signature scheme is an important primitive in cryptography,it allows members in a group to generate signatures anonymously on behalf of the whole group.In view of the practical application of such schemes,it is necessary to allow users’registration and revocation when necessary,which makes the construction of dynamic group signature schemes become a significant direction.On the basis of(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017),we present the first full dynamic group signature scheme over ring,and under the premise of ensuring security,the efficiency of the scheme is improved mainly from the following three aspects:the size of keys,the dynamic construction of a Merkle hash tree that used to record the information of registered users,and the reuse of the leaves in this tree.In addition,the public and secret keys of both group manager and trace manager are generated by a trusted third party,which prevents the situation that the two managers generate their respective public key and secret key maliciously.Compared with the counterpart of the scheme in(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017)over ring,the expected space complexity of the Merkle tree used in our work down almost by half,and the computational complexity of its update has been reduced by a notch because of the dynamic construction of the hash tree. | Yiru Sun Yanyan Liu Bo Wu | 2018 | Cybersecurity2018，1，1： | 0 |
| 9 | Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients显示文摘Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after infection.Dysfunction of immunity in COVID-19 patients has been considered as one of the fatal factors for patients,especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However,the mechanism of cytokine-induced lymphopenia in COVID-19 is very unclear.IL-2 is critical for the proliferation,differentiation,and function of T cells,including Tregs,CD4+,and CD8+effector cells.6 Here,we reported the negative relationship between the concentration of soluble IL-2 receptor(sIL-2R)and T-cell number in blood from COVID-19 patients.In vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling,which could be rescued by strong IL-2 signaling.Our data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients. | Yaguang Zhang Xiaojing Wang Xuezhen Li Dong Xi Ruizhi Mao Xiaohui Wu Shipeng Cheng Xiaoyu Sun Chunyan Yi Zhiyang Ling Liyan Ma Qin Ning Yiru Fang Bing Sun Di Wu | 2020 | Cellular & Molecular Immunology2020，17，8： | 0 |
| 10 | OPTIMIZATIONOFTHECONTINUOUSAFFINITY-RECYCLEEXTRACTIONPROCESS显示文摘对单级和多级CARE过程分别进行了最优化分析.单级过程的优化目标函数(F1)为REC和PF的积,而多级过程则将获得一定纯度的目标组分情况下的回收率和CARE级数之比为优化目标函数F2.结果表明,当膜对目标和杂质组分的截留率相等时,在一定的洗脱液流速re范围内,对于每一个re均存在一对应的循环流速re,使F1和F2最大,并且最大值相等;当re一定时,最佳rr随膜的截留率和亲和载体对目标组分的结合分率的增大而降低.对于多级过程,当膜对杂质的截留小于对目标组分的截留时,只存在一组最佳的操作条件(即re和rr). | DONG Xiaoyan GAN Yiru SUN Yan (Dept. of Chemical Engineering) | 1996 | Transactions of Tianjin University1996，2，1： | 0 |
| 11 | An Asymmetric Controlled Bidirectional Quantum State Transmission Protocol显示文摘In this paper,we propose an asymmetric controlled bidirectional transmission protocol.In the protocol,by using the thirteen-qubit entangled state as the quantum channel,Alice can realize the transmission of a two-qubit equatorial state for Bob and Bob can transmit a four-qubit equatorial state for Alice under the control of Charlie.Firstly,we give the construction of the quantum channel,which can be done by performing several H and CNOT operations.Secondly,through implementing the appropriate measurements and the corresponding recovery operations,the desired states can be transmitted simultaneously,securely and deterministically.Finally,we analyze the performance of the protocol,including the efficiency,the necessary operations and the classical communication costs.And then,we describe some comparisons with other protocols.Since our protocol does not require auxiliary particles and additional operations,the classic communication costs less while achieving the multi-particle bidirectional transmission,so the overall performance of the protocol is better. | Yiru Sun Yuling Chen Haseeb Ahmad Zhanhong Wei | 2019 | Computers, Materials & Continua2019，，4： | 0 |
| 12 | An efficient fully dynamic group signature with message dependent opening from lattice显示文摘Message-dependent opening is one of the solutions to solve the problem of the tracing manager owns excessive power.In this paper,we present a new lattice-based fully dynamic group signature scheme with message-dependent opening by combining an improved version of the fully dynamic group signature scheme proposed by Ling et al and the double encryption paradigm.In addition,we propose an improved underlying zero knowledge protocol,it has a soundness error 1 max(n,p)+1 that is better than the Stern-like protocol,which helps to bring down the communication complexity of the protocol and hence the signature scheme.Our scheme constrains the power of group managers by adding an admitter,and the signature size has a logarithmic relationship with the group size. | Yiru Sun Yanyan Liu | 2021 | Cybersecurity2021，4，1： | 0 |
| 13 | Real- and momentum-indirect neutral and charged excitons in a multi-valley semiconductor显示文摘Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still limited.Here,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent photoluminescence.Together with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum origin.Remarkably,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics. | Zhiheng Huang Yuhui Li Tao Bo Yanchong Zhao Fanfan Wu Lu Li Yalong Yuan Yiru Ji Le Liu Jinpeng Tian Yanbang Chu Xiaozhou Zan Yalin Peng Xiuzhen Li Yangkun Zhang Kenji Watanabe Takashi Taniguchi Zhipei Sun Wei Yang Dongxia Shi Shixuan Du Luojun Du Guangyu Zhang | 2023 | National Science Open2023，2，4： | 0 |
| 14 | Green Oxidation of Isochromans to Isochromanones with Molecular Oxygen Catalyzed by a Tetranuclear Vanadium Cluster显示文摘Comprehensive Summary Isochromanone is the core structure of many bioactive compounds.Direct oxidation of isochromans is one of leading methods for the construction of isochromanones,while most established processes remain suffering from the use of environmentally unfriendly metal oxidants,harsh reaction conditions,and the difficulty in catalyst recycling and product separation.Herein,we report a convenient,cost-effective,and green method for the synthesis of high-value added isochromanones via isochroman oxidations with O_(2) by a novel heterogeneous vanadium cluster catalyst(Cat.1)under mild conditions.This reaction protocol demonstrates high catalytic activity with good catalyst recyclability and reusability for a wide scope of substrates. | Huixin Huang Baokuan Chen Yiru Fu Jing Sun Yanfeng Bi Ming-Dong Zhou | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
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