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| 1 | Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice显示文摘AIM:To investigate the role of O-GlcNAcylation of nuclear factor-kappa B(NF-κB) in retinal ganglion cell(RGC) death and analysedthe effect of Aralia elata(AE) on neurodegeneration in diabetic mice.METHODS: C57BL/6mice with streptozotocin-induced diabetes were fed daily with AE extract or control(CTL) diet at the onset of diabetes mellitus(DM). Two months after injection of streptozotocin or saline,the degree of cell death and the expression of O-GlcN Ac transferase(OGT),N-acetyl-b-D-glucosaminidase(OGA),O-GlcN Acylated proteins,and O-GlcNAcylation of NF-κB were examined.RESULTS: AE did not affect the metabolic status of diabetic mice. The decrease in the inner retinal thickness(P<0.001 vs CTL,P<0.01 vs DM) and increases in RGCs with terminal deoxynucleotidyl transferase-mediated d UTP nick end labelling(P<0.001 vs CTL,P<0.0001 vs DM),glial activation,and active caspase-3(P<0.0001 vs CTL,P<0.0001 vs DM) were blocked in diabetic retinas of AE extract-fed mice. Expression levels of protein O-Glc NAcylation and OGT were increased in diabetic retinas(P<0.0001 vs CTL),and the level of O-GlcNAcylation of the NF-κB p65 subunit was higher in diabetic retinas than in controls(P<0.0001 vs CTL). AE extract downregulated O-GlcNAcylation of NF-κB and prevented neurodegeneration induced by hyperglycemia(P<0.0001 vs DM).CONCLUSION: O-GlcNAcylation of NF-κB is concerned in neuronal degeneration and that AE prevents diabetes-induced RGC apoptosis via downregulation of NF-κB O-GlcNAcylation. Hence,O-GlcNAcylation may be a new object for the treatment of DR,and AE may have therapeutic possibility to prevent diabetes-induced neurodegeneration. | Seong-Jae Kim Min-Jun Kim Mee- Young Ckoi Yoon-Sook Kim Ji-Myong Yoo Eun-Kyung Hong Sunmi Ju Wan-Sung Choi | 2017 | International Journal of Ophthalmology(English edition)2017，10，8： | 3 |
| 2 | 用化学热解沉积法制备硫化镉薄膜的微结构(英文)显示文摘在载玻片或ITO涂覆的玻璃上采用化学热解法沉积CdS固体薄膜 ,沉积温度在 35 0~ 5 4 0℃之间 .部分制备的CdS薄膜进行 2 0 0~ 6 0 0℃的退火热处理 .由SEM ,AFM和XRD分析测量退火热处理前后的CdS薄膜的微观结构 .结果表明 ,沉积温度低于 5 4 0℃以下制备的CdS薄膜具有类六方结构相 ,当高于 5 4 0℃沉积的CdS薄膜则显示纤锌矿相 .在 4 0 0℃化学热解沉积的CdS薄膜经高于 5 0 0℃的后热处理也可获得纤锌矿相 . | Cha DeoKjoon Kim Sunmi 黄宁康 刘金蓉 陈剑 | 2004 | 红外与毫米波学报2004，23，1： | 2 |
| 3 | Major perfluoroalkyl acid (PFAA) concentrations and influence of food consumption among the general population of Daegu, Korea显示文摘 | Kyunghee Ji Sunmi Kim Younglim Kho Joon Sakong Domyung Paek Kyungho Choi | 2012 | Science of the Total Environment2012，，： | 1 |
| 4 | Elevated micro RNA ‐34a in obesity reduces NAD <sup>+</sup> levels and SIRT 1 activity by directly targeting NAMPT显示文摘 | Sung‐E Choi Ting Fu Sunmi Seok Dong‐Hyun Kim Eunkyung Yu Kwan‐Woo Lee Yup Kang Xiaoling Li Byron Kemper Jongsook K. Kemper | 2013 | Aging Cell2013，，6： | 1 |
| 5 | A study of diffusional behavior of n-paraffin in urea/n-paraffin adduct by high field-gradient HNMR spectroscopy显示文摘 | KIM Sunmi KIMURA Hideaki KUROKI Shigeki | 2003 | Chemical Physics Letters2003，367，56： | 1 |
| 6 | Differential expression of heat shock protein mRNAs under in vivo glutathione depletion in the mouse retina显示文摘 | Joo Wan Park Cheil Moon Sunmi Yun So Yeun Kim Yong Chul Bae Myung-Hoon Chun Jung-Il Moon | 2006 | Neuroscience Letters2006，，3： | 1 |
| 7 | Hydroxylated Polybrominated Diphenyl Ethers and Bisphenol A in Pregnant Women and Their Matching Fetuses: Placental Transfer and Potential Risks显示文摘 | YI WAN KYUNGHO CHOI SUNMI KIM | 2010 | Environ Sci Technol2010，，44： | 1 |
| 8 | The Optical Property of CPD Prepared CdS Films显示文摘CdS films were prepared with chemical pyrolysis deposition (CPD) at 450℃ during film growth, and these CdS films were also annealed at different temperature from 200-500℃.The optical property of the CdS films before and after annealing was investigated at different measuring temperature from 10K to 300K. Optical absorption spectra show that the absorption edge is towards the shorter wavelengths, and the energy band gaps deduced from the plots of (α·hν) 2 vs. hν are increased when the measuring temperature is decreased. The optical behaviors of the CdS films annealed at a certain temperature seem to have the similar tendency at different measuring temperature. Based on dE- ex/dT curve dependent on annealing temperature, some phenomena related microstructure in CdS films could be found. | 车德溶 Sunmi Kim | 2004 | Journal of Wuhan University of Technology(Materials Science)2004，19，3： | 0 |
| 9 | Synthesis and characterization of lanthanum-doped curcumin-functionalized antimicrobial copper oxide nanoparticles显示文摘Flavonoid-based nanomaterials have extensive potential in antimicrobial research because of their non-toxicity,large-scale producibility,and chemical stability.An efficient combination of flavonoids and rare earth metals can have excellent antimicrobial properties owing to their robust medicinal and physicochemical properties.In this study,we synthesized copper oxide(CuO)nanoparticles(NPs)using a reflux reaction and repeated doping with the rare earth element lanthanum to prepare La-CuO NPs.Next,these La-CuO NPs were functionalized with the flavonoid curcumin,and the modified NPs were termed Cu-La-CuO NPs.These NPs were chemically characterized via microscopic and spectroscopic techniques,including transmission electron microscopy(TEM),scanning electron microscopy(SEM),ultraviolet-visible(UV-Vis)adsorption,Fourier transform infrared spectroscopy(FT-IR)spectroscopy,and powder X-ray diffraction(XRD)analysis.The SEM-EDX analysis reveals the elements doped into the native CuO NPs.The TEM and XRD characterization results show,in detail,the distinct morphology and phase composition of the prepared CuO,La-CuO,and Cu-La-CuO NPs.The antimicrobial activity of the Cu-La-CuO NPs was investigated on bacteria,such as Escherichia coli(E.coli)and Bacillus subtilis(B.subtilis),and fungi,including Aspergillus niger(A niger).The Cu-La-CuO NPs delivers excellent antimicrobial effects due to the incorporation of lanthanum and curcumin into the CuO NPs.The Cu-La-CuO NPs show excellent antimicrobial potentials with an adequate zone of inhibition values around 2.2 and 2.9 mm in E.coli and A.niger,respectively.Live and dead analysis studies suggest the antimicrobial effects of lanthanum and curcumin moieties over native CuO NPs.The obtained results are significant in developing of rare earth metal-based flavo no id-conjugated nanocomposites against typical microbes. | Sai Varshith Chakka Naveen Thanjavur Sunmi Lee Sanghyo Kim | 2023 | Journal of Rare Earths2023，41，10： | 0 |
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