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| 1 | Oxidative stress and inflammatory signaling in cerulein pancreatitis显示文摘Oxidative stress is considered to be an important regulator of the pathogenesis of acute pancreatitis.Reactive oxygen species(ROS)regulate the activation of inflammatory cascades,the recruitment of inflammatory cells and tissue damage in acute pancreatitis.A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression,which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB(NF-κB)and activator protein-1(AP-1),signal transducer and activator of transcription 3(STAT3),and mitogen-activated protein kinases(MAPKs).Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB,AP-1,STAT3,and MAPKs;this crosstalk amplifies the inflammatory cascade in acute pancreatitis.Therapeutic studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-induced pancreatitis.Since oxidative stress may activate inflammatory signaling pathways and contribute to thedevelopment of pancreatitis,antioxidant therapy may alleviate the symptoms or prevent the development of pancreatitis.Since chronic administration of high doses of antioxidants may have deleterious effects,dosage levels and duration of antioxidant treatment should be carefully determined. | Ji Hoon Yu Hyeyoung Kim | 2014 | World Journal of Gastroenterology2014，20，46： | 19 |
| 2 | Role of oxygen free radicals in patients with acute pancreatitis显示文摘The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis.The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis.METHODS: The plasma levels of C-reactive protein (CRP),lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers.RESULTS: Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index.CONCLUSION: The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease. | Byung Kyu Park Jae Bock Chung Jin Heon Lee Jeong Hun Suh Seung Woo Park Si Young Song Hyeyoung Kim Kyung Hwan Kim Jin Kyung Kang | 2003 | World Journal of Gastroenterology2003，9，10： | 18 |
| 3 | Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia显示文摘Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018. | Tae-Kyeong Lee Hyunjung Kim Minah Song Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Go Eun Yang Hyeyoung Kim Taek Geun Ohk Myoung Cheol Shin Jun Hwi Cho Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 4 | Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables显示文摘 | Steven J. Lehotay Kyung Ae Son Hyeyoung Kwon Urairat Koesukwiwat Wusheng Fu Katerina Mastovska Eunha Hoh Natchanun Leepipatpiboon | 2010 | Journal of Chromatography A2010，，16： | 3 |
| 5 | Long-Term Outcome of Laparoscopic Versus Open Liver Resection for Hepatocellular Carcinoma: A Case-Controlled Study with Propensity Score Matching显示文摘 | Hyeyoung Kim Kyung-Suk Suh Kwang-Woong Lee Nam-Joon Yi Geun Hong Suk-Won Suh Tae Yoo Min-Su Park YoungRok Choi Hae Won Lee | 2014 | Surgical Endoscopy2014，，3： | 3 |
| 6 | Living-Donor Liver Transplantation Associated With Higher Incidence of Hepatocellular Carcinoma Recurrence Than Deceased-Donor Liver Transplantation显示文摘 | Min-Su Park Kwang-Woong Lee Suk-Won Suh Tae You YoungRok Choi Hyeyoung Kim Geun Hong Nam-Joon Yi Choon-Hyuck David Kwon Jae-Won Joh Suk-Koo Lee Kyung-Suk Suh | 2014 | Transplantation Journal2014，，1： | 2 |
| 7 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 2 |
| 8 | Suppression of NF-kB activationg and cytokine prodution by N-Acetylcysteine in pancreatic acinar cells显示文摘 | Hyeyoung K Jeong YS Kwan HR | 2000 | Free Radical Biol Med2000，29，9： | 1 |
| 9 | The Empirical Study of Structural Relationship among Port Logistics Service Quality, Port Reputation and Customer Loyalty of Liner Ships显示文摘 | Kim SungReup Joo HyeYoung | 2008 | Journal of Korea Trade2008，，3： | 1 |
| 10 | Nonlinear oscillation in a periodically forced loaded hanging cable 显示文摘 | Choi Y S Hyeyoung Oh Her Mckennea P J | 1994 | Journal of Computational and Applied Mathematics1994，52，3： | 1 |
| 11 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 1 |
| 12 | SOCS3 and PPAR - γ ligands inhibit the expression of IL - 6 and TGF - 131 by regulating JAK2/ STAT3 signaling in pancreas 显示文摘 | Ji H Y Kyung H K Hyeyoung K | 2008 | The International Journal of Biochemistry & Cell Biology2008，40，： | 1 |
| 13 | Oxidative stress related proteome changes in Helicobacter pylori infected human gastric mucosa显示文摘 | HYE YB JOO WL HYEYOUNG K | 2004 | Biochem J2004，379，2： | 1 |
| 14 | Histologically proven non‐alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation显示文摘 | Hyeyoung Kim Kyoungbun Lee Kwang‐Woong Lee Nam‐Joon Yi Hae Won Lee Geun Hong YoungRok Choi Tae You Suk‐Won Suh Ja June Jang Kyung‐Suk Suh | 2014 | Clin Transplant2014，，5： | 1 |
| 15 | Inhibition of lipid peroxidation, NF - k B Activation and IL - 8 prodection by Rebamip-ide in helicobacter pylori stimulated gastric epithelial cell显示文摘 | Hyeyoung K Phd Jeong Yeon Seo | 2000 | Dig Dis Sci2000，45，3： | 1 |
| 16 | Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother显示文摘AIM To investigate the rates of pretransplantation fetalmaternal microchimerism(MC) and its effect on rejection in children receiving maternal liver grafts. METHODS DNA or blood samples before liver transplantation(LT) were available in 45 pediatric patients and their mothers. The presence of pretransplantation MC to non-inherited maternal antigens(NIMAs)(NIMA-MC) in the peripheral blood was tested using nested PCRsingle-strand conformation polymorphism analysis for the human leukocyte antigen(HLA)-DRB1 alleles. NIMA-MC was successfully evaluated in 26 of the 45 children. Among these 45 pediatric LT recipients,23 children(51.1%) received transplants from maternal donors and the other 22 from non-maternal donors.RESULTS Among these 26 children,pretransplantation NIMAMC was detected in 23.1%(n = 6),6.1(range,0.8-14) years after birth. Among the children with a maternal donor,the rate of biopsy-proven cellular rejection(BPCR) was 0% in patients with NIMA-MC positivity(0/3) and those with HLA-DR identity with the mother(0/4),but it was 50% in those with NIMA-MC negativity(5/10). Patients with NIMA-MC positivity or HLA-DR identity with the mother showed significantly lower BPCR rate compared with NIMA-MC-negative patients(0% vs 50%,P = 0.04). NIMA-MC-positive patients tended to show lower BPCR rate compared with NIMAMC-negative patients(P = 0.23). CONCLUSION The presence of pretransplantation NIMA-MC or HLADR identity with the mother could be associated with BPCR-free survival in pediatric recipients of LT from maternal donors. | Nam-Joon Yi Min-Su Park Eun Young Song Hye Young Ahn Jeik Byun Hyeyoung Kim Suk Kyun Hong Kyungchul Yoon Hyo-Sin Kim Sung-Woo Ahn Hae Won Lee Young Rok Choi Kwang-Woong Lee Kyung-Suk Suh Myoung Hee Park | 2017 | World Journal of Gastroenterology2017，23，45： | 1 |
| 17 | Species Identification of Mycobacteria by PCR-Restriction Fragment Length Polymorphism of the rpoB Gene显示文摘 | Hee-Jung Park Sang-Nae Cho | 2000 | Journal of Clinical Microbiology2000，38，8： | 1 |
| 18 | Novel Polymorphic Region of the rpoB Gene Containing Mycobacterium Species-Specific Squences and Its Use in Identification of Mycobacteria显示文摘 | Hye-Eun Bang Gill-Han Bai | 2003 | Journal of Clinical Microbiology2003，41，5： | 1 |
| 19 | Type-II CdS nanoparticle-ZnO nanowire heterostructure arrays fabricated by a solution process: Enhanced photocatalytic activity 显示文摘 | Youngjo Tak Hyeyoung Kim Dongwook | 2008 | Chem Commun2008，，38： | 1 |
| 20 | Com- parison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and veg etables显示文摘 | Lehotay S J Kyung A S Hyeyoung K | 2010 | Journal of Chromatography A2010，，： | 1 |
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