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| 1 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 2 | A new approach to low-level image processing 显示文摘 | Smith S M Brady I M Susan | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 3 | A new approach to low level image processing 显示文摘 | SMITH S M BRADY M SUSAN | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 4 | A New Approach to Low Level Image Processing显示文摘 | S M Smith Brady M Susan | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 5 | A new approch to low-level image processing显示文摘 | Susan Smith Brady S M | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 6 | A new approach to low level image processing显示文摘 | Smith S M Brady J M Susan | 1997 | Int J Comput Vis1997，23，1： | 1 |
| 7 | SUSAN- A new approach to low level image processing 显示文摘 | SMITH S M SUSAN B J M | 1997 | International Journal of Computer1997，25，1： | 1 |
| 8 | A New Approach to Low Level Image Processing显示文摘 | Smith S M Susan B M | 1997 | International Journal of Computer Version1997，23，1： | 1 |
| 9 | Power Relationships among Top Managers: Does Top Management Ream Power Distribution Matter for Organizational Performance? 显示文摘 | Anne Smith Susan M Houghton Jacqueline N Hood Joel A Ryman | 2006 | Journal of Business Research2006，，59： | 1 |
| 10 | A new approach to low level image processing 显示文摘 | SMITH S M BRAND J M SUSAN | 1997 | International of Computer Vision1997，23，1： | 1 |
| 11 | A new approach to low level image processing显示文摘 | Brady J M Susan | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 12 | A new approach to lowlevel image processing显示文摘 | Smith S Susan Brady M | 1997 | International Journal ofComputer Vision1997，23，1： | 1 |
| 13 | A new approch to low-lev- el image processing显示文摘 | Smith S M Brady J M SUSAN | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 14 | Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates显示文摘 | McCurdy Carrie E Bishop Jacalyn M Williams Sarah M Grayson Bernadette E Smith M Susan Friedman Jacob E Grove Kevin L | 2009 | Journal of Clinical Investigation2009，，： | 1 |
| 15 | Power relationship among top managers: Does top manage- ment team power distribution matter for organizatio- nal performance?显示文摘 | Smith A Susan M H Jacqueline N H | 2006 | Journal of Business Research2006，，59： | 1 |
| 16 | 通过社区干预减少急症住院患者显示文摘目前,社区干预效果的研究证据尚不充分,EmmaWallace及其同事探索其他方法以证明社区干预的效果
减少急症住院患者,既是医疗服务质量的一个衡量指标,又可以使医疗保健支出呈螺旋式上升,这一目标在国际上引发广泛关注。 | Emma Wallace Susan M Smith Tom Fahey Martin Roland 梁立智 | 2016 | 英国医学杂志中文版2016，0，6： | 0 |
| 17 | 通过社区干预减少急症住院患者显示文摘目前,社区干预效果的研究证据尚不充分,Emma Wallace及其同事探索其他方法以证明社区干预的效果。减少急症住院患者,既是医疗服务质量的一个衡量指标,又可以使医疗保健支出呈螺旋式上升,这一目标在国际上引发广泛关注。1998年至2013年,英国的急症住院人数增长了47%,从360万增至530万, | Emma Wallace Susan M Smith Tom Fahey Martin Roland 梁立智 | 2016 | 中国医院院长2016，12，12： | 0 |
| 18 | 他汀类药物用于心血管疾病的一级预防显示文摘他汀类药物是目前英国最常用的药物,也是世界上最常用的药物之一。尽管他汀类药物的专利到期后价格有所下降,但在医疗预算经常超支的背景下,它仍占用着大量的医疗保健资源。预计到2020年,他汀类药物在全球的销售额可达1万亿美元。对已确诊患有心血管疾病的人群是否应该使用他汀类药物问题,通常不存在争议,而对是否可在无心血管疾病的人群中,作为针对心血管疾病的一级预防药物却存在着争议。 | Paula Byrne John Cullinan Susan M Smith 潘天园(译) 任菁菁(校) | 2020 | 英国医学杂志中文版2020，23，4： | 0 |
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