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| 1 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 2 | Electrodeposition and mechanical and corrosion resistance properties of Ni–W/SiC nanocomposite coatings显示文摘 | Yingwu Yao Suwei Yao Lu Zhang Hongzhi Wang | 2006 | Materials Letters2006，，1： | 1 |
| 3 | Electrodeposi- tion and mechanical and corrosion resistance properties of Ni-W/SiC nanocomposite coatings 显示文摘 | Yingwu Yao Suwei Yao Lu Zhang | 2007 | Materials Let- ters2007，61，1： | 1 |
| 4 | Electrodeposition and mechanical and corrosion resistance properties of Ni - W/ SiC nanocomposite coatings 显示文摘 | Yao Yingwu Yao Suwei Zhang Lu | 2007 | Materials Letters2007，61，1： | 1 |
| 5 | Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine显示文摘We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH hapten.The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule.Behavio ral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization.These results demonstrate that the lipopeptide-based vaccine has invo ked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH. | Fan Liao Hanxuan Wang Yuankun Dao Kai Yuan Jiazhen Lu Jie Shi Ying Han Suwei Dong Lin Lu | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 6 | Template Synthesis and Characterization of Cu2O/TiO2 Coaxial Nanocable for Photocatalysis显示文摘 | WANG Hongzhi LIU Ning LU Jing YAO Suwei JIANG Shisheng ZHANG Weiguo | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
| 7 | Rationally designed ultrathin Ni(OH)_(2)/titanate nanosheet heterostructure for photocatalytic CO_(2) reduction显示文摘Dye-sensitized photocatalysis has been extensively studied for photocatalytic solar energy conversion due to the advantage in capturing long-wavelength photons with a high absorption coefficient.The rational integration of photosensitizer with semiconductor and cocatalyst to collaboratively operate in one system is highly desired.Here,we fabricate a Ni(OH)_(2)-loaded titanate nanosheet(Ni(OH)_(2)/H_(2)Ti_(6)O_(13))composite for high-performance dye-sensitized photocatalytic CO_(2) reduction.The ultrathin H_(2)Ti_(6)O_(13) nanosheets with negative surface charge provide an excellent support to anchor the dye photosensitizer,while the loaded Ni(OH)2 serves as an adsorbent of CO_(2) and electron sink of photoelectrons.As such,the photoelectrons derived from the[Ru(bpy)3]Cl_(2) sensitizer can be targeted transfer to the Ni(OH)_(2) active sites via the H_(2) Ti_(6)O_(13) nanosheets linker.A high CO production rate of 1801μmol g^(-1) h^(-1) is obtained over the optimal Ni(OH)_(2)/H_(2)Ti_(6)O_(13),while the pure H_(2)Ti_(6)O_(13) shows significantly lower CO_(2) reduction performance.The work is anticipated to trigger more research attention on the rational design and synthesis of earth-abundant transition metal-based cocatalysts decorated on ultrathin 2D platforms for artificially photocatalytic CO_(2) reduction. | Wanru Liao Suwei Lu Weihang Chen Shuying Zhu Yuzhou Xia Min-Quan Yang Shijing Liang | 2022 | Green Chemical Engineering2022，3，3： | 0 |
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