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| 1 | Structural and molecular basis for foot-andmouth disease virus neutralization by two potent protective antibodies显示文摘Dear Editor,Foot-and-mouth disease(FMD)is an economically devastating and highly contagious viral disease of cloven-hoofed animals with a global distribution.The causative agent,FMD virus(FMDV)is a small non-enveloped RNA virus,belonging to the Aphthoviruses genus within Picornaviridae family(Tuthill et al.,2010).Control of FMD has been largely reliant on vaccinations with inactivated virus vaccines.However,significant antigenic diversity within FMDV serotypes and inability of the vaccines to induce immune protection for a long duration of time impinge on the efficacy of available vaccines.The roles of neutralizing antibodies(NAbs)as the principal protective components of the immune responses to FMDV vaccination or infection have been well established(Pay and Hingley,1987;Juleff et al.,2009).Passive immunization of NAbs has also been demonstrated to be effective in curing FMD and many viral diseases(Harmsen et al.,2007;Qiu et al.,2018).A deep understanding of the molecular basis for viral neutralization by antibodies and the identification of key viral epitopes would aid in the development of potent rationally designed broad-spectrum vaccine. | Hu Dong Pan Liu Manyuan Bai Kang Wang Rui Feng Dandan Zhu Yao Sun Suyu Mu Haozhou Li Michiel Harmsen Shiqi Sun Xiangxi Wang Huichen Guo | 2022 | Protein & Cell2022，13，6： | 3 |
| 2 | Diffusion tensor imaging study of fractional anisotropy values and the area of both cerebral peduncles in healthy adults显示文摘Diffusion tensor imaging was performed in 105 volunteers free of central nervous system lesions.No differences were found in fractional anisotropy between the left and right cerebral peduncles among subjects(P > 0.05).The lower limit value of fractional anisotropy was 0.36,and the asymmetry ratio was 0.77.The area and lower limit value of the cerebral peduncles were 0.90 cm2 and 0.83,respectively.These results will be useful in evaluating the diagnosis of Wallerian degeneration following cerebral infarction. | Zhibin Song Suyue Pan Yanling Zhou Yanjiang Dong Haimao Liang Zhengfeng Zhu | 2011 | Neural Regeneration Research2011，6，10： | 1 |
| 3 | Expert consensus on prevention and control of COVID-19 in the neurological intensive care unit(first edition)显示文摘During the COVID-19 epidemic,the treatment of critically ill patients has been increasingly difficult and challenging.During the epidemic,some patients with neurological diseases also have COVID-19,which could be misdiagnosed and cause silent transmission and nosocomial infection.Such risk is high in a neurological intensive care unit(NCU).Therefore,prevention and control of epidemic in critically ill patients is of utmost importance.The principle of NCU care should include comprehensive screening and risk assessment,weighing risk against benefits and reducing the risk of COVID-19 transmission while treating patients as promptly as possible. | Furong Wang Jingyi Liu Ping Zhang Wen Jiang Le Zhang Meng Zhang Junfang Teng Jinquan Wang Xiaoqi Xie Jie Cao Wei Li Yongming Wu Hao Zhou Yingying Su Suyue Pan Liping Liu | 2020 | Stroke & Vascular Neurology2020，5，3： | 1 |
| 4 | Why do stroke patients with negative motor evoked potential show poor limb motor function recovery?显示文摘Negative motor evoked potentials after cerebral infarction,indicative of poor recovery of limb motor function,tend to be accompanied by changes in fractional anisotropy values and the cerebral peduncle area on the affected side,but the characteristics of these changes have not been reported.This study included 57 cases of cerebral infarction whose motor evoked potentials were tested in the 24 hours after the first inspection for diffusion tensor imaging,in which 29 cases were in the negative group and 28 cases in the positive group.Twenty-nine patients with negative motor evoked potentials were divided into two groups according to fractional anisotropy on the affected side of the cerebral peduncle:a fractional anisotropy<0.36 group and a fractional anisotropy≥0.36 group.All patients underwent a regular magnetic resonance imaging and a diffusion tensor imaging examination at 1 week,1,3,6 and 12 months after cerebral infarction.The Fugl-Meyer scores of their hemiplegic limbs were tested before the magnetic resonance and diffusion tensor imaging examinations.In the negative motor evoked potential group,fractional anisotropy in the affected cerebral peduncle declined progressively,which was most obvious in the first 1–3 months after the onset of cerebral infarction.The areas and area asymmetries of the cerebral peduncle on the affected side were significantly decreased at 6 and 12 months after onset.At 12 months after onset,the area asymmetries of the cerebral peduncle on the affected side were lower than the normal lower limit value of 0.83.Fugl-Meyer scores in the fractional anisotropy≥0.36 group were significantly higher than in the fractional anisotropy<0.36 group at 3–12 months after onset.The fractional anisotropy of the cerebral peduncle in the positive motor evoked potential group decreased in the first 1 month after onset,and stayed unchanged from 3–12 months;there was no change in the area of the cerebral peduncle in the first 1–12 months after cerebral infarction.These findings confirmed that if the fractional anisotropy of the cerebral peduncle on the affected side is<0.36 and the area asymmetries<0.83 in patients with negative motor evoked potential after cerebral infarction,then poor hemiplegic limb motor function recovery may occur. | Zhibin Song Lijuan Dang Yanling Zhou Yanjiang Dong Haimao Liang Zhengfeng Zhu Suyue Pan | 2013 | Neural Regeneration Research2013，8，29： | 0 |
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