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| 1 | Identification, occurrence, and validation of DRE and ABRE Cis-regulatory motifs in the promoter regions of genes of Arabidopsis thaliana显示文摘Plants posses a complex co-regulatory network Researchwhich helps them to elicit a response under diverse adverse conditions.We used an in silico approach to identify the genes with both DRE and ABRE motifs in their promoter regions in Arabidopsis thaliana.Our results showed that Arabidopsis contains a set of 2,052 genes with ABRE and DRE motifs in their promoter regions.Approximately 72%or more of the total predicted 2,052 genes had a gap distance of less than 400 bp between DRE and ABRE motifs.For positional orientation of the DRE and ABRE motifs,we found that the DR form(one in direct and the other one in reverse orientation)was more prevalent than other forms.These predicted 2,052 genes include 155 transcription factors.Using microarray data from The Arabidopsis Information Resource(TAIR)database,we present 44 transcription factors out of 155 which are upregulated by more than twofold in response to osmotic stress and ABA treatment.Fifty-one transcripts from the onepredicted above were validated using semiquantitative expression analysis to support the microarray data in TAIR.Taken together,we report a set of genes containing both DRE and ABRE motifs in their promoter regions in A.thaliana,which can be useful to understand the role of ABA under osmotic stress condition. | Sonal Mishra Aparna Shukla Swati Upadhyay Sanchita Pooja Sharma Seema Singh Ujjal J.Phukan Abha Meena Feroz Khan Vineeta Tripathi Rakesh Kumar Shukla Ashok Shrama | 2014 | Journal of Integrative Plant Biology2014，56，4： | 5 |
| 2 | Treatment of wheat straw using tannase and white-rot fungus to improve feed utilization by ruminants显示文摘Background: Current research to enrich cattle feed has primarily focused on treatment using white rot fungi, while there are scarce reports using the enzyme tannase, which is discussed only in reviews or in the form of a hypothesis. In this context, the aim of the present study was to evaluate the effect of tannase on wheat straw(WS)and also the effect of lyophilized tannase at concentrations of 0.1%, 0.2%, and 0.3%(w/w) on WS followed by fermentation with Ganoderma sp. for 10 d and compared in relation to biochemical parameters, crude protein(CP)content, and nutritional value by calculating the C/N ratio in order to improve the nutritional value of cattle feed.Results: Penicillium chorlesii, a tannase-producing microorganism, produced 61.4 lU/mL of tannase in 54 h when 2%(w/v) tannic acid(TA) was initially used as a substrate in medium containing(% w/v) sucrose(1.0), NaN03(1.0), and MgS〇4(0.08 pH, 5.0) in a 300-L fermentor(working volume 220 L), and concomitantly fed with 1.0%(w/v) TA after24 h. The yield of partially purified and lyophilized tannase was 5.8 lU/mg. The tannin-free myco-straw at 0.1%(w/w) tannase showed 37.8%(w/w) lignin degradation with only a 20.4%(w/w) decrease in cellulose content and the in vitro feed digestibility was 32.2%. An increase in CP content(up to 1.28-fold) along with a lower C/N ratio of25.0%, as compared to myco-straw, was obtained.Conclusions: The use of tannin-free myco-straw has potential to improve the nutritional content of cattle feed.This biological treatment process was safe, eco-friendly, easy to perform, and was less expensive as compared to other treatment methods. | Shailendra Raghuwanshi Swati Misra Rajendra Kumar Saxena | 2014 | Journal of Animal Science and Biotechnology2014，5，2： | 5 |
| 3 | Drought Tolerance in Rice: Focus on Recent Mechanisms and Approaches显示文摘Drought stress is a serious limiting factor to rice production,which results in huge economic losses.It is becoming a more serious issue with respect to the global climate change.Keeping in view of the current and forecasted global food demand,it has become essential to enhance the crop productivity on the drought-prone rainfed lands with priority.In order to achieve the production target from rainfed areas,there is a requirement of rice varieties with drought tolerance,and genetic improvement for drought tolerant should be a high priority theme of research in the future.Breeding for drought tolerant rice varieties is a thought-provoking task because of the complex nature and multigenic control of drought tolerant traits would be a major bottleneck for the current research.A great progress has been made during last two decades in our understanding of the mechanisms involved in adaptation and tolerance to drought stress in rice.In this review,we highlighted the recent progresses in physiological,biochemical and molecular adaptation of rice to drought tolerance.A brief discussion on the molecular genetics and breeding approaches for drought tolerance in rice will be focused for the future crop improvement program for development of drought tolerant rice varieties. | Debabrata PANDA Swati Sakambari MISHRA Prafulla Kumar BEHERA | 2021 | Rice science2021，28，2： | 3 |
| 4 | Dengue:epidemiology,prevention and pressing need for vaccine development显示文摘Dengue fever is a mosquito born viral infection,and the complicated form of dengue is dengue hemorrhagic fever(DHF).In the recent decades incidence and distribution of dengue has increased dramatically.Dengue viruses belong to family flaviviridae with four serotypes and are transmitted mainly by mosquito Aedes aegypti.Today almost two-fifth of world’s population (2.5 million) is at risk of dengue and no specific antiviral drug or vaccine is available against it.Uncontrolled population growth in Africa and South East Asia has increased number of susceptible hosts in urban and semi urban areas.About 40%of world population resides in the high risk area for dengue transmission.According to latest estimates by WHO,yearly 50 to 100 million infections occur globally,this includes around 500 000 DHF and 22 000 deaths,mostly among children.Only symptomatic treatment in the form of analgesic,antipyretics and body fluid management is provided to the patient.Prevention strategies mainly focus on two approaches, firsdy on activities to control vector and secondly on activities to protect human from mosquito bite but there is always concerns regarding their sustainably and effectiveness.Theoretically development of an effective dengue vaccine is feasible and production of an effective and affordable vaccine could be a viable option to save humans from this dreadful disease. Conceptually vaccine production is possible,but it has to be tetravalent,providing immunity against all serotypes.Few candidate vaccines are in advance stage of their development:however international cooperation is needed to make these vaccines available on cheaper rates to the poor and vulnerable countries.Objective of this review is to discuss various aspects related to dengue,its epidemiology,available preventive methods,need for vaccine and challenges in its development. | Kuldeep Kumar Pankaj Kumar Singh Juhi Tomar Swati Baijal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 2 |
| 5 | CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis显示文摘Background and Aims:Cirrhosis patients exhibit cyto-penia,and,at times refractory neutropenia to granulocyte colony-stimulating factor(G-CSF),which acts through the CSF3-receptor(CSF3R),and changes in CSF3R can affect the response.We conducted this study to assess the CSF3R status and its relevance in cirrhotic patients.Methods:Cirrhotic patients(n=127)and controls(n=26)with clini-cally indicated bone marrow(BM)examination were stud-ied.BM assessment was done by qRT-PCR and immunohis-tochemistry(IHC)for CSF3R.Circulating G-CSF,CSF3R,and carcinoembryonic antigen cell adhesion molecule-1(CEACAM1)were measured.BM hematopoietic precursor cells and their alterations were examined by flow cytom-etry.The findings were validated in liver cirrhosis patients who received G-CSF for severe neutropenia.Results:The mean age was 48.6±13.4 years,and 80.3%were men.Circulatory CSF3R reduction was noted with the advance-ment of cirrhosis,and confirmed by qRT-PCR and IHC in BM.CSF3R decline was related to decreased hematopoietic stem cells(HSCs)and downregulation of CSF3R in the re-maining HSCs.Cocultures confirmed that CEACAM1 led to CSF3R downregulation in BM cells by possible lysosomal degradation.Baseline low peripheral blood-(PB)-CSF3R also predisposed development of infections on follow-up.Decreased CSF3R was also associated with nonresponse to exogenous G-CSF treatment of neutropenia.Conclu-sions:Advanced liver cirrhosis was associated with low CSF3R and high CEACAM1 levels in the BM and circula-tion,making patients prone to infection and inadequate response to exogenous G-CSF. | Chhagan Bihari Sukriti Baweja Seggere Murlaikrishna Shasthry Deepika Lal Preeti Negi Swati Thangariyal Dinesh Mani Tripathi Shiv Kumar Sarin | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 2 |
| 6 | Prevalence of Plateau Iris in Primary Angle Closure Suspects显示文摘 | Rajesh S. Kumar Mani Baskaran Paul T.K. Chew David S. Friedman Swati Handa Raghavan Lavanya Lisandro M. Sakata Hon-Tym Wong Tin Aung | 2008 | Ophthalmology2008，，3： | 2 |
| 7 | Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction显示文摘BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac biomarkers.Rapid restoration of brisk flow in the coronary vasculature is critical in reducing mortality and morbidity.In patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective option.AIM To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after thrombolysis.METHODS This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary arteries.Patients received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another group.The primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the procedure.The secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 d.RESULTS The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,respectively.Smoking rate was 54.6%and 55.8%in the routine and delayed groups,respectively.Thrombolysis was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,respectively.No significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reported MACCE in the two groups did not demonstrate any significant correlation.Secondary endpoints such as angina,dyspnea,and major bleeding were non-significantly different between the two groups.CONCLUSION Delayed PCI pharmacoinvasive strategy in a critical diseased but not completely occluded artery beyond 24 h in patients who have been timely thrombolyzed seems a reasonable strategy. | Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi | 2023 | World Journal of Cardiology2023，15，1： | 1 |
| 8 | Acute respiratory infection due to chlamydia pneumoniae :current status of diagnostic methods 显示文摘 | Kumar Swati Hammerschlag | 2007 | Clin Infect Dis2007，44，4： | 1 |
| 9 | Obesity as potential breast cancer risk factor for postmenopausal women显示文摘Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018.Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016.There is a significant relationship between breast cancer risk and obesity.Premature menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk,because adipose tissue acts as the major reservoir for estrogen biosynthesis after menopause.Lofty estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal women.This review explains body fat as a peripheral site for estrogen biosynthesis,estrogen exposure affecting body fat distribution,and the mechanism of estrogen production from body fats. | Swati Sucharita Mohanty Prafulla Kumar Mohanty | 2021 | Genes & Diseases2021，8，2： | 1 |
| 10 | High temperature oxidation behavior of AISI 304L stainless steel—Effect of surface working operations显示文摘 | Swati Ghosh M. Kiran Kumar Vivekanand Kain | 2013 | Applied Surface Science2013，，： | 1 |
| 11 | Photocatalytic degradation of Eriochrome Black T dye using well-crystalline anatase TiO 2 nanoparticles显示文摘 | Sushil Kumar Kansal Swati Sood Ahmad Umar S.K. Mehta | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 12 | Comparative cytotoxicity of nanoparticles and ions to Escherichia coli in binary mixtures显示文摘The objective of this study was to understand toxicity of mixture of nanoparticles(NPs)(ZnO and TiO_2)and their ions to Escherichia coli. Results indicated the decrease in percentage growth of E. coli with the increase in concentration of NPs both in single and mixture setups.Even a small concentration of 1 mg/L was observed to be significantly toxic to E. coli in binary mixture setup(exposure concentration:1 mg/L ZnO and 1 mg/L TiO_2; 21.15% decrease in plate count concentration with respect to control). Exposure of E.coli to mixture of NPs at 1000 mg/L(i.e.,1000 mg/L ZnO and 1000 mg/L TiO_2)resulted in 99.63% decrease in plate count concentration with respect to control. Toxic effects of ions to E. coli were found to be lesser than their corresponding NPs. The percentage growth reduction was found to be 36% for binary mixture of zinc and titanium ions at the highest concentration(i.e.,803.0 mg/L Zn and593.3 mg/L Ti where ion concentrations are equal to the Zn ions present in 1000 mg/L ZnO NP solution and Ti^(+4) ions present in 1000 mg/L TiO_2 NP solution). Nature of mixture toxicity of the two NPs to E. coli was found to be antagonistic. The alkaline phosphatase(Alp)assay indicated that the maximum damage was observed when E. coli was exposed to 1000 mg/L of mixture of NPs. This study tries to fill the knowledge gap on information of toxicity of mixture of NPs to bacteria which has not been reported earlier. | Swati Srivastaua Arun Kumar | 2017 | Journal of Environmental Sciences2017，29，5： | 1 |
| 13 | A new proxy blind signature scheme based on DLP显示文摘 | Swati Verma Birendra Kumar Sharma | 2012 | International Journal of Information&Network Security2012，1，2： | 1 |
| 14 | Adult onset moyamoya disease:Institutional experience显示文摘 | Swati Dayanand Chinchure Hima Shriniwas Pendharkar Arun Kumar Gupta | 2011 | Neurology India2011，59，5： | 1 |
| 15 | Conservation Strategy for African Medicinal Species: In Vitro Biotechnological Approach显示文摘The use of medicinal plants for different therapeutic values is well documented in African continent.African diverse biodiversity hotspots provide a wide range of endemic species,which ensures a potential medicinal value.The feasible conservation approach and sustainable harvesting for the medicinal species remains a huge challenge.However,conservation approach through different biotechnological tools such as micropropagation,somatic embryogenesis,synthetic seed production,hairy root culture,molecular markers based study and cryopreservation of endemic African medicinal species is much crucial.In this review,an attempt has been made to provide different in vitro biotechnological approaches for the conservation of African medicinal species.The present review will be helpful in further technology development and deciding the priorities at decision-making levels for in vitro conservation and sustainable use of African medicinal species. | Priyanka Jha Swati Chahal Devendra Kumar Pandey Joginder Singh Ram Prasad Vijay Kumar | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 1 |
| 16 | Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways显示文摘Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus(CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 cells line. In Balb/c mouse neonates, viral RNA copy number was determined by real time PCR. Results:The results showed reduced CHIKV protein expression on andrographolide treatment in CHIKV-infected human peripheral blood mononuclear cells, Vero cells and THP-I cell line.In vivo, andrographolide treatment to CHIKV-infected neonates reduced viral RNA copy number. Further. andrographolide also increased cytotoxic T lymphocytes both in vitro and in vivo. Andrographolide also activated host innate immune pathways, viz., protein kinase R.phosphorylated eukaryotic initiation factor 2 α, retinoic acid inducible gene-Ⅰ and interferon regulatory factor 3/7, thereby increasing IFN-a secretion. CHIKV-induced nuclear factor κlight chain enhancer of activated B cells and tumor necrosis factor-a was also reduced on andrographolide treatment. Conclusion: Andrographolide inhibits CHIKV by suppressing viral protein expression and up-regulating host innate immunity and hence could be an effective therapeutic agent against CHIKV infection. | Swati Gupta Kamla Prasad Mishra Paban Kumar Dash Manmohan Parida Lilly Ganju Shashi Bala Singh | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，3： | 1 |
| 17 | Hammerschlag, Acute Respiratory Infection Due to Chlamydia pneumoniae: Current Status of Diagnostic Methods, 568 显示文摘 | Swati Kumar Margaret R | 2007 | CID2007，44，15： | 1 |
| 18 | Processing-microstructure-yield strength correlation in a near β Ti alloy, Ti–5Al–5Mo–5V–3Cr显示文摘 | Sujoy Kumar Kar Swati Suman S. Shivaprasad Atanu Chaudhuri Amit Bhattacharjee | 2014 | Materials Science & Engineering A2014，，： | 1 |
| 19 | Expression of multidrug resistance proteins in retinoblastoma显示文摘AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance.METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy(PCNC) were also prepared. Their chemosensitivity to chemotherapeutic agents(vincristine, etoposide and carboplatin) were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma cells.RESULTS: Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein(P-gp) was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1(Mrp-1) expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associatedprotein(Lrp) was observed in the drug resistant Y79 cells as well as in PCNC.CONCLUSION: Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy. | Swati Shukla Arpna Srivastava Sunil Kumar Usha Singh Sandeep Goswami Bhavna Chawla Mandeep Singh Bajaj Seema Kashyap Jasbir Kaur | 2017 | International Journal of Ophthalmology(English edition)2017，10，11： | 0 |
| 20 | Consequences of forced migration during early childhood on cognitive well-being in later childhood in Andhra Pradesh,India显示文摘Unlike its short-term impact on consumption and income,forced migration is expected to deliver a permanent shock to the overall well-being of households,specifically children in the stage of infancy.Studies on the effect of forced migration on child cognitive well-being are few in number.Therefore,the present study is intended to examine the consequences of forced migration during infancy on child cognition at later age.We hypothesized that the effect of forced migration on child cognitive wellbeing can be mitigated by social support.The study used longitudinal data from three waves of the Young Lives Study(YLS)conducted in 2002,2006–2007,and 2009 in the state of Andhra Pradesh,India.We used bivariate and multivariate regression models to analyze the consequences of forced migration in early childhood on the cognitive wellbeing in later childhood.The information on forced migration was collected in Wave 1(at age 1),whereas the information on the cognitive well-being of the children was collected in Wave 3(at age 8).Child cognitive well-being was measured using scores obtained by the children on the Peabody Picture Vocabulary Test(PPVT),math,Early Grade Reading Assessment(EGRA),and memory tests.The results of the bivariate analysis show that the mean PPVT,math,EGRA,and memory scores obtained by children from the migrated households were lower than those obtained by children from the non-migrated households.Results of the multivariate linear regression models also show that children from the migrated households were statistically less likely to achieve higher scores on math(coefficient:-2.008,95%C.I.-3.108,-0.908),EGRA(coefficient:-0.746,95%C.I.-1.366,-0.126),and memory(coefficient:-0.503,95%C.I.-0.834,-0.173)as compared to children from the non-migrated households.Our findings also indicate that the effect of forced migration on child cognitive wellbeing was not mitigated by social support.Findings of this study conclude that forced migration during infancy has a significant effect on child cognitive well-being at later age.Therefore,interventions should be made,paying attention to the most vulnerable children who were displaced during critical development ages. | Ashish Kumar Upadhyay Swati Srivastava Chhavi Paul | 2017 | International Journal of Population Studies2017，3，2： | 0 |
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