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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Effect of coronary bifurcation angle on clinical outcomes in Chinese patients treated with crush stenting: a subgroup analysis from DKCRUSH-1 bifurcation study显示文摘背景分叉角度可以影响压碎 stenting 的临床的结果。我们寻求了比较高度(60 ( | CHEN Shao-liang ZHANG Jun-jie YE Fei CHEN Yun-dai FANG Wei-yi WEI Meng HE Ben SUN Xue-wen YANG Song CHEN Jin-guo SHAN Shou-jie TIAN Nai-liang LI Xiao-bo LIU Zhi-zhong KAN Jing Lee Michael Kwan Tak W | 2009 | Chinese Medical Journal2009，，4： | 5 |
| 3 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 4 | Clinical outcome after management of unprotected left main in-stent restenosis after bare metal or drug-eluting stents显示文摘也的背景培植赤裸的金属 stent (BMS ) 或 drug-eluting stent (DES ) 与没有防卫的左主要狭窄(UPLMS ) 为病人在每天实践被使用了。仍然有数据 regading 的缺乏 UPLMS in-stent 狭窄(ISR ) 的随后的结果。在 stenting 被包括以后,现在的学习与 UPLMS ISR 在 BMS 或 DES.Methods 病人的培植以后在 determing 瞄准了 UPLMS ISR 病人的临床的结果。主要端点是累积主要不利心脏的事件(向) ,包括心脏的死亡,心肌的梗塞(Ml ) ,和目标容器 revascularization (TVR ).Results UPLMS ISR 率 14.8%(n=73, 15.7% 在 BMS 以后, 14.5% 为 DES ) 在以后平均(3.89 | CHEN Shao-liang XU Bo Gary Mintz YE Fei ZHANG Jun-jie KAN Jing SUN Xue-wen ZHANG Ai-ping CHEN Jin-guo QIAN Jun Kwan Tak W | 2010 | Chinese Medical Journal2010，，7： | 3 |
| 5 | Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions显示文摘 | CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING Shi-qing Tak W Kwan | 2012 | Chinese Medical Journal2012，，12： | 2 |
| 6 | The impact of p53 and p73 on aneuploidy and cancer显示文摘 | Richard T Tak W Gerry M | 2008 | Trends in Cell Biology2008，18，4： | 1 |
| 7 | Effects of arteminsinin and its derivatives on growth inhibition and apoptosis of oral cancer cells 显示文摘 | Nam W Tak J Ryu JK | 2007 | Head Neck2007，29，4： | 1 |
| 8 | Modulation of cellular apoptotic potential: contributions to on-cogenesis显示文摘 | VUK STAMBOLIC TAK W MAK JAMES R WOODGETT | 1999 | Oncogene1999，18，45： | 1 |
| 9 | Design and Evaluation of Adaptive Secure Protocol for E-Commerce显示文摘 | Tak W S Lee Y Park K E | 2001 | IEEE International Conference on Computer Communications and Networks2001，，10： | 1 |
| 10 | Encapsulation of Curcumin in Cationic Micelles Suppresses Alkaline Hydrol- ysis 显示文摘 | MANDY H M L HANNAH C TAK W K | 2008 | Langmuir2008，24，： | 1 |
| 11 | Revolving Doors Reexamined: Occupational Sex Segregation Over the Life Course显示文摘 | Tak W C | 1999 | American Soci- ological Review1999，，1： | 1 |
| 12 | Efficacy and safety of sorafenib in patients in advanced hepatocellular carcinoma: Asia-Pacific trial subgroup by baseline transaminase/a-fetoprotein levels 显示文摘 | QIN S YANG T TAK W | 2009 | J Clin Oncol2009，27，15： | 1 |
| 13 | Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases显示文摘 | Hwang D Fischer NH Jang BC Tak H Kim JK Lee W | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 14 | Tourists' satisfaction, rec- ommendation and revisiting Singapore 显示文摘 | Tak K H David W Alvin H | 2007 | Tourism Management2007，28，： | 1 |
| 15 | The use of ebselen for radioprotection in cultured cells and mice显示文摘 | Tak J K Park J W | | 0，，8： | 1 |
| 16 | Ultimate load and release time controllable non-explosive separation device using a shape memory alloy actuator 显示文摘 | Tak W Lee M Kim B | 2011 | Journal of Mechanical Science & Technology2011，25，5： | 1 |
| 17 | Effects of arternisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells 显示文摘 | Nam W Tak J Ryu J K | 2007 | Head Neck2007，29，4： | 1 |
| 18 | Validation of the Chinese Version of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38)显示文摘 | Law C C Tak Lam W W Fu Y T | | 0，，02： | 1 |
| 19 | Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells 显示文摘 | Nam W Tak J Ryu JK | 2007 | Head Neck2007，29，4： | 1 |
| 20 | Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis显示文摘 | SOMSEN G W TAK Y H TORAO J S | 2009 | J Chromatogr A2009，216，18： | 1 |
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