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| 1 | Computed tomography-guided transpulmonary radiofrequency ablation for hepatocellular carcinoma located in hepatic dome显示文摘瞄准:为了决定,执行计算断层摄影术(CT ) 的可行性为位于肝的屋顶的肝细胞癌(HCC ) 指导了 transpulmonary 射频脱离(RFA ) 。方法:有包括位于肝的屋顶的七个小瘤的 HCC 的七个病人的一个总数从 2004 年 4 月被对待到 2004 年 12 月。指导 CT 的 transpulmonary RFA 基于一个标准化精力协议用一个凉爽尖端的类型电极(电子学公司) 被执行。位于肝的屋顶的所有肿瘤不由平常的超声(美国) 是可检测的方法。损害直径从 15 ~ 27 公里。结果:RFA 在所有病人是技术上可行的。刺过程被执行两次或更少和全部的平均成就时间是 40.6 min。本地肿瘤控制在所有病人被完成。坏死直径从 25 ~ 35 公里。吝啬的后续时期是 9.6 (7-14 瞬间) 瞬间。在后续点没有本地复发。要求肋膜的排水的气胸是主要复杂并发症,它在七个病人(28.6%) 中的二个被观察。然而,它与胸引流管改善了,并且试管能在 2-3 d 以内被移开。没有另外的主要复杂并发症被观察。结论:指导 CT 的刺为位于几乎不由美国可检测的肝的屋顶的肿瘤的治疗是有用的,尽管气胸可以有时作为复杂并发症发生。在有在人工的胸膜渗漏方法不是适当的为胸膜的粘附的情况中,指导 CT 的 RFA 因此被认为是为位于肝的屋顶的 HCC 的其他的治疗。 | MitsuoToyoda KatsuhikoHoriuchi KenjiKatakai SatoruKakizaki NaondoSohara KenSato HitoshiTakagi MasatomoMori Takahito Nakajima | 2006 | World Journal of Gastroenterology2006，12，4： | 18 |
| 2 | Laparoscopy in the management of hilar cholangiocarcinoma显示文摘The use of minimally invasive surgery has become widely accepted in many gastrointestinal fields,even in patients with malignancy.However,performing laparoscopic resection for the treatment of hilar cholangiocarcinoma is still not universally accepted as an alternative approach to open surgery,and only a limited number of such procedures have been reporteddue to the difficulty of performing oncologic resection and the lack of consensus regarding the adequacy of this approach.Laparoscopy was initially limited to staging,biopsy and palliation.Recent technological developments and improvements in endoscopic procedures have greatly expanded the applications of laparoscopic liver resection and lymphadenectomy,and some reports have described the use of laparoscopic or robot-assisted laparoscopic resection for hilar cholangiocarcinoma as being feasible and safe in highly selected cases,with the ability to obtain an adequate surgical margin.However,the benefits of major laparoscopic surgery have yet to be conclusively proven,and carefully selecting patients is essential for successfully performing this procedure. | Akihiro Cho Hiroshi Yamamoto Osamu Kainuma Yorihiko Muto Hiroo Yanagibashi Toru Tonooka Takahito Masuda | 2014 | World Journal of Gastroenterology2014，20，41： | 18 |
| 3 | Confirming Stereochemical Structures of Strigolactones Produced by Rice and Tobacco显示文摘主要 strigolactones (SL ) 由米饭生产了(Oryza sativa L。cv。Nipponbare ) 并且烟草(Nicotiana tabacum L。cv。Michinoku 号码 1 ) 被净化,他们的 stereochemical 结构被在 ESILC/MS 和 GCMS 为他们的 NMR 和 CD 数据和保留时间和集体破碎与光学地纯的合成标准作比较决定。从米饭植物的根流出物净化的 SL 是 orobanchol, orobanchyl 醋酸盐,和 ent-2-epi-5-deoxystrigol。除了这些 SL, 7-oxoorobanchyl 醋酸盐并且通常认为三 methoxy-5-deoxystrigol 异构体被最小公倍数 /MS 检测。7-oxoorobanchyl 醋酸盐的生产似乎发生在早生长阶段,当它仅仅在在孵化的第一个星期期间收集的根流出物被检测。烟草的根流出物包含了至少 11 SL,包括其结构尚待被澄清的通常认为的 didehydro-orobanchol 的 solanacol, solanacyl 醋酸盐, orobanchol, ent-2-epi-orobanchol, orobanchyl 醋酸盐, ent-2-epi-orobanchyl 醋酸盐, 5-deoxystrigol, ent-2-epi-5-deoxystrigol,和三异构体。而且,二 sorgolactone 异构体然而并非 sorgolactone 被最小公倍数 /MS 分析作为次要的 SL 检测。注意米饭植物生产了仅仅 orobanchol 类型 SL 是吸引人的,源于 ent-2-epi-5-deoxystrigol,而是 orobanchol 类型和 strigol 类型 SL,源于 5-deoxystrigol 在烟草植物被检测。 | Xiaonan Xie Kaori Yoneyama Takaya Kisugi Kenichi Uchida Seisuke Ito Kohki Akiyama Hideo Hayashi Takao Yokota Takahito Nomura Koichi Yoneyama | 2013 | Molecular Plant2013，6，1： | 9 |
| 4 | 云南省水稻白叶枯病菌致病力差异的地理分布显示文摘使用12个分别持有不同抗病基因(Xa1,Xa2,Xa3,Xa4,Xa5,Xa7,Xa8,Xa10,Xa11,Xa13,Xa14和Xa21)的近等基因系水稻白叶枯病鉴别品种及3个对照品种(IR24,Toyonishiki和Sigadagabo),鉴别了从云南省收集的138个菌株。结果根据致病谱可以将这些菌株分成A~J共10组。A组菌株仅对Toyonishiki和Sigadagabo两个对照品种致病,J组菌株则能对9个鉴别品种和3个对照品种致病。对不同海拔采集的菌株进行致病力分析的结果表明,从大理、武定等较高海拔粳稻种植区采集的菌株致病力较弱,在鉴别品种上病斑的平均长度不到50mm;而元江、景洪、潞西等低海拔杂交稻种植区采集的菌株致病力较强,在鉴别品种上的病斑平均长度超过100mm。从高海拔稻区到低海拔稻区,病菌致病力有逐步增强的趋势。 | 李成云 TAKAHITO Noda HIROKAZU Ochiai KAZUO Ise HISATOSHI Kaku | 2002 | 西南农业学报2002，15，4： | 7 |
| 5 | Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2显示文摘Medical treatment has progressed significantly over the past decade towards achieving and maintaining clinical remission in patients with refractory ulcerative colitis(UC). Proposed mediators of inflammation in UC include pro-inflammatory cytokines such as tumor necrosis factor-α(TNF-α) and interleukin-2, and the cellsurface adhesive molecule integrin α4β7. Conventional therapeutics for active UC include 5-aminosalicylic acid, corticosteroids and purine analogues(azathioprine and 6-mercaptopurine). Patients who fail to respond to conventional therapy are treated with agents such as the calicineurin inhibitors cyclosporine and tacrolimus, the TNF-α inhibitors infliximab or adalimumab, or a neutralizing antibody(vedolizumab) directed against integrin α4β7. These therapeutic agents are of benefit for patients with refractory UC, but are not universally effective. Our recent research on TNF-α shedding demonstrated that inhibition of annexin(ANX) A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease(IBD) inflammation. In this review, we provide an overview of therapeutic treatments that are effective and currently available for UC patients, as well as some that are likely to be available in the near future. We also propose the potential of ANX A2 as a new molecular target for IBD treatment. | Satoshi Tanida Tsutomu Mizoshita Keiji Ozeki Takahito Katano Hiromi Kataoka Takeshi Kamiya Takashi Joh | 2015 | World Journal of Gastroenterology2015，21，29： | 4 |
| 6 | Micro-nano electromechanical system by bulk silicon micromachining显示文摘 | Masayoshi Esashi Takahito Ono | 2002 | 光学精密工程2002，10，6： | 3 |
| 7 | CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy显示文摘AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after PD.Computed tomography(CT)images were evaluated every 6 mo after PD for follow-up.Hepatic steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield units.Liver biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo biopsies.To compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver biopsy.Double-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy specimens.RESULTS:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after PD.Those patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin resistance.Liver biopsy was performed in four patients with NAFLD after PD.All four patients showed moderate-to-severe steatosis and NASH was diagnosed in two.Numbers of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy specimens.The number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with metabolic syndrome specimens,which indicated the presence of significantly more Kupffer cells in NAFLD after PD than in NAFLD associated with metabolic syndrome.Similarly,more CD14+ cells,namely,LPS-sensitized Kupffer cells,were observed in NAFLD after PD than in NAFLD associated with metabolic syndrome.Regarding NASH,more CD68+ cells and CD14+ cells were observed in NASH after PD specimens than in NASH associated with metabolic syndrome.This showed that more Kupffer cells and more LPS-sensitized Kupffer cells were present in NASH after PD than in NASH associated with metabolic syndrome.These observations suggest that after PD,Kupffer cells and LPS-sensitized Kupffer cells were significantly upregulated,not only in NASH,but also in simple fatty liver.CONCLUSION:NAFLD after PD is characterized by both malnutrition and the up-regulation of CD14 on Kupffer cells.Gut-derived endotoxin appears central to the development of NAFLD after PD. | Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 8 | Applications of human hepatitis B virus preS domain in bio-and nanotechnology显示文摘Human hepatitis B virus(HBV) is a member of the family Hepadnaviridae, and causes acute and chronic infections of the liver. The hepatitis B surface antigen(HBs Ag) contains the large(L), middle(M), and small(S) surface proteins. The L protein consists of the S protein, pre S1, and pre S2. In HBs Ag, the pre S domain(pre S1 + pre S2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Based on these characteristics of pre S, several pre S-based diagnostic and therapeutic materials and systems have been developed. Pre S1-specific monoclonal antibodies(e.g., MA18/7 and KR127) can be used to inhibit HBV infection. A myristoylated pre S1 peptide(amino acids 2-48) also inhibits the attachment of HBV to Hepa RG cells, primary human hepatocytes, and primary tupaia hepatocytes. Antibodies and antigens related to the components of HBs Ag, pre S(pre S1 + pre S2), or pre S1 can be available as diagnostic markers of acute and chronic HBV infections. Hepatocyte-targeting delivery systems for therapeutic molecules(drugs, genes, or proteins) are very important for increasing the clinical efficacy of these molecules and in reducing their adverse effects on other organs. The selective delivery of diagnosticmolecules to target hepatocytic cells can also improve the efficiency of diagnosis. In addition to the full-length HBV vector, pre S(pre S1 + pre S2), pre S1, and pre S1-derived fragments can be useful in hepatocyte-specific targeting. In this review, we discuss the literature concerning the applications of the HBV pre S domain in bio- and nanotechnology. | Riki Toita Takahito Kawano Jeong-Hun Kang Masaharu Murata | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 9 | Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study显示文摘 | Miwa Kawanaka Mitsuhiko Suehiro Gotaro Yamada Jun Nakamura Keisuke Hino Ken Nishino Junji Yodoi Hajime Nakamura Hirofumi Kawamoto Takahito Oka Noriyo Urata Daisuke Goto | 2013 | 2013 (defa)2013，，： | 2 |
| 10 | Potential of adenovirus‐mediated REIC / Dkk ‐3 gene therapy for use in the treatment of pancreatic cancer显示文摘 | Daisuke Uchida Hidenori Shiraha Hironari Kato Teruya Nagahara Masaya Iwamuro Junro Kataoka Shigeru Horiguchi Masami Watanabe Akinobu Takaki Kazuhiro Nouso Yasutomo Nasu Takahito Yagi Hiromi Kumon Kazuhide Yamamoto | 2014 | J Gastroenterol Hepatol2014，，5： | 1 |
| 11 | General Frame Work of Research Topics Utilizing the 3-D Full-Sacle Earthquake Testing Facility显示文摘 | Masayoshi SATO Takahito INOUE | 2004 | Journal of Japan Association for Engineering2004，4，3： | 1 |
| 12 | Relationships between genetic variation measured by microsatellite DNA markers and a fitness-related trait in the guppy (Poecilia reticulata)显示文摘 | Takahito Shikano | 2002 | Aquaculture2002，209，： | 1 |
| 13 | Dynamics of dissolved O2,CO2,CH4 and N2O in a tropical coastal swamp in southern Thailand显示文摘 | SHINGO U CHUN-SIM U G TAKAHITO Y | 2000 | Biogeochemistry2000，49，： | 1 |
| 14 | Effect of microstructure on fatigue behavior of AZ31 magnesium alloy显示文摘 | Sotomi Ishihara Zhenyu Nan Takahito Goshima | 2007 | Materials Science and Engineering A2007，，： | 1 |
| 15 | 显示文摘 | YUKI K TAKAHITO N SAKI K | 2007 | J Plays Chem A2007，111，： | 1 |
| 16 | Electroluminescence as a probe for elucidating electrical conductivity in a deoxyribonucleic acid-cetyltrimethylammonium lipid complex layer显示文摘 | Kunio Hirata Takahito Oyamada | 2004 | Applied Physics Letters2004，85，9： | 1 |
| 17 | Rescue pulmonary vein isolation for hemodynamically unstable atrial fibrillation storm in a patient with an acute extensive myocardial infarction显示文摘 | Morishima Itsuro Sone Takahito Tsuboi Hideyuki | 2013 | BMC Cardiovascular Disorders2013，12，1： | 1 |
| 18 | Marker-based estimation of heritability for body color variation in Japanese flounder Paralichthys olivaceus 显示文摘 | Takahito S | 2005 | Aq- uaculture2005，249，： | 1 |
| 19 | Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats 显示文摘 | Takahito O Takuro M Masaaki T | 2008 | Neurosci Lett2008，430，2： | 1 |
| 20 | Effects of Prophylactic Splenic Artery Modulation on Portal Overperfusion and Liver Regeneration in Small-for-Size Graft显示文摘 | Yuzo Umeda Takahito Yagi Hiroshi Sadamori Hiroyoshi Matsukawa Hiroaki Matsuda Susumu Shinoura Kenji Mizuno Ryuichi Yoshida Takayuki Iwamoto Daisuke Satoh Noriaki Tanaka | 2008 | Transplantation2008，，5： | 1 |
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