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| 1 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 2 | 合成中间体烷基缩水甘油醚显示文摘烷基缩水甘油醚含有—个化学性质稳定的醚键和一个高活性的环氧键,二者由亚甲基隔开。水,醇,酸,胺或硫醇等亲核试剂与其作用时,活泼的环氧键易开环生成相应的烷基甘油衍生物。在这些衍生物中,烷基甘油醚由于其药用性质和物理性质而倍受关注。例如,烷基缩水甘油醚作为一种重要的工业中间体而得到广泛应用。烷基缩水甘油醚有两种生产工艺:(1)在流酸,三氟化硼乙醚络合物或回氯化锡等酸性催化剂存在下,把表卤醇加到醇中生成卤代醇醚。 | Kouichi Urata 李彩虹 | 1996 | 化学与粘合1996，，1： | 5 |
| 3 | Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C显示文摘AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects. | Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 4 | Angiotensin II Antagonist Prevents Electrical Remodeling in Atrial Fibrillation显示文摘 | Hideko Nakashima Koichiro Kumagai Hidenori Urata Naoki Gondo Munehito Ideishi Kikuo Arakawa | 2000 | Circulation: Journal of the American Heart Association2000，，22： | 3 |
| 5 | A Trial Study of Propranolol and Zhigancao Decoction on the Central Depressant and Anti-osteoporosic Action in Ovariectomized Rats显示文摘Objective: This study was originally designed to observe the effects of propranolol (a β-blocker) and Zhigancao Decoction (炙甘草汤 ZGCD) on bone mass in ovariectomized rats. Methods: Thirty-eight female Sprague-Dawley rats were divided into four groups initially, a sham-operated group (Sham, n=7), a model ovariectomized (OVX) group (Model, n=7), a propranolol group (Pro, n=12) and a ZGCD group (ZGCD, n=12). After 15 weeks of treatment, the expected effects were not found. In order to verify the situations of the experiment, we modified the study by administering calcitonin to a subgroup of the tested Pro and ZGCD rats. Results: The Pro and ZGCD treatments showed decreased heart rate and plasma norepinephrine level, but neither an increased bone mass nor any bone metabolism differences from the model rats were found. However, the OVX-induced bone loss was prevented by the sequent treatment of calcitonin. Conclusions: The results provide no evidence that the β-blocker propranolol may stimulate bone formation, and do not justify its use for clinical treatment of osteoporosis. | Zhang Wenping Masayuki Kanehara Zhang Yanjun Guo Yi Shigeru Urata Hiroyuki Nakazawa Takayasu Murakami Atushi Takeda Torao Ishida | 2008 | Journal of Traditional Chinese Medicine2008，28，1： | 3 |
| 6 | Calculation of child and adult standard liver volume for liver transplantation显示文摘 | Koichi Urata Seiji Kawasaki Hidetoshi Matsunami Yasuhiko Hashikura Toshihiko Ikegami Shinpachi Ishizone Yoshitaka Momose Atsushi Komiyama Masatoshi Makuuchi | 1995 | Hepatology1995，，5： | 3 |
| 7 | Hepatitis B virus infection in Indonesia显示文摘Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 8 | Calculation of child and adult standard liver volume for liver transplantation显示文摘 | Koichi Urata Seiji Kawasaki Hidetoshi Matsunami Yasuhiko Hashikura Toshihiko Ikegami Shinpachi Ishizone Yoshitaka Momose Atsushi Komiyama Masatoshi Makuuchi | 1995 | Hepatology1995，，5： | 2 |
| 9 | Standard liver volume in adults显示文摘 | K Urata Y Hashikura T Ikegami M Terada S Kawasaki | 2000 | Transplantation Proceedings2000，，7： | 2 |
| 10 | Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4显示文摘BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been increasing.However,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor PS.AIM To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4.METHODS This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic ERCP.As a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were included.One-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS 3-4.RESULTS The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),respectively.In the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate analysis.Therapeutic success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or 4.Nevertheless,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics. | Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 11 | Topological pruning enables ultra-low Rayleigh scattering in pressure-quenched silica glass显示文摘Silica glass is the most indispensable material in optical communication applications due to its superior optical properties.The transmission loss of silica glass has been reduced over the past 30 years by continuous efforts toward decreasing density fluctuations by lowering of fictive temperature,e.g.,through improvements in processing or doping.A recent study has shown that shrinkage of structural voids by hot compression is a promising way to further decrease the loss.However,an atomic understanding of the pressure effect is still lacking.Here,using molecular simulations,we connect the void shrinkage to topological pruning of silica network.Two physical models predict that the Rayleigh scattering loss of pressure-quenched silica glass can be reduced by>50%when the glass is quenched at an appropriate pressure(4 GPa in our simulation).Our studies are consistent with available experimental results and demonstrate topologically optimized structure can give desirable properties for optical applications of silica as well as other glasses with similar network structure. | Yongjian Yang Osamu Homma Shingo Urata Madoka Ono John C.Mauro | 2020 | npj Computational Materials2020，，1： | 2 |
| 12 | Nonsurgical policy for treatment of bilioenteric anastomotic stricture after living donor liver transplantation显示文摘 | Atsuyoshi Mita Yasuhiko Hashikura Yuichi Masuda Yasunari Ohno Koichi Urata Yuichi Nakazawa Toshihiko Ikegami Masaru Terada Hironori Yamamoto Shin‐ichi Miyagawa | 2007 | Transplant International2007，，4： | 2 |
| 13 | Review of the diagnosis of gastrointestinal lanthanum deposition显示文摘Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure.Although lanthanum carbonate is safe,recently,lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the literature.This review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic,radiological,and histological features,prevalence,and outcome,by reviewing relevant clinical studies,case reports,and basic research findings,to better understand the endoscopic manifestation of gastrointestinal lanthanum deposition.The possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated;in patients without gastric mucosal atrophy,gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric body.In the gastric mucosa with atrophy,lanthanum-related lesions likely appear as annular or granular whitish lesions.Moreover,these white lesions are probably more frequently observed in the lower part of the stomach,where intestinal metaplasia begins. | Masaya Iwamuro Haruo Urata Takehiro Tanaka Hiroyuki Okada | 2020 | World Journal of Gastroenterology2020，26，13： | 2 |
| 14 | Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats显示文摘OBJECTIVE: To investigate the effect of acupuncture at acupoint of Shenshu(BL 23) in ovariectomized rats and sham-operated rats.METHODS: Female Sprague-Dawley rats were divided into the following four groups(n = 12 each):sham operation only(Sham), sham operation with acupuncture(Sham + ACP), ovariectomy only(OVX), and ovariectomy with acupuncture(OVX +ACP). Operations were performed at the 9 th week of age. Acupuncture of Shenshu(BL 23) was started at the 11 th week of age and conducted 3 times per week until the 26 th week of age.RESULTS: Among ovariectomized rats, the acupuncture-treated rats had significantly lower bodyweights and cross-linked N-telopeptide of type 1 collagen levels in the urine after 3 weeks of acupuncture treatment, higher bone mineral density of the lumbar vertebra after 7 weeks, and smaller trabecular separation of the sixth lumbar vertebra,measured by micro-computed tomography, after17 weeks than control rats. These effects were not observed in sham-operated rats. Blood concentrations of estradiol were significantly higher in the OVX + ACP group than in the untreated group. Acupuncture treatment increased plasma testosterone levels in sham-operated rats, while this increase was not observed in OVX rats.CONCLUSION: Acupuncture of Shenshu(BL 23)prevents bone loss and structural changes by suppressing bone resorption. | Atsushi Takeda Teruhiko Koike Shigeru Urata Torao Ishida Yoshiharu Oshida | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 2 |
| 15 | Widespread tissue distribution of human chymase显示文摘 | Urata H Gantan SF | 1994 | J Hyperten1994，12，： | 2 |
| 16 | Hall–Petch relationship in friction stir welds of equal channel angular-pressed aluminium alloys显示文摘 | Yutaka S. Sato Mitsunori Urata Hiroyuki Kokawa Keisuke Ikeda | 2003 | Materials Science & Engineering A2003，，1： | 2 |
| 17 | A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings显示文摘Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination. Assuming that metastasis had occurred at the time lumbar pain developed, the patient reached the level of gait disturbance within only 4 mo, showing a rapid advancement of symptoms. If early diagnosis had been possible, treatment could be performed before acute myelopathy progressed to complete paralysis. We speculate that the terminal stage of HCC is not only liver failure associated with intrahepatic lesions but also metastasis to other regions, treatment for individual pathologies therefore, will be needed, which constitutes an important issue. | Katsuyoshi Tamaki Ichiro Shimizu Mari Urata Nao Kohno Hiroshi Fukuno Susumu Ito Nobuya Sano | 2007 | World Journal of Gastroenterology2007，13，19： | 2 |
| 18 | Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study显示文摘 | Miwa Kawanaka Mitsuhiko Suehiro Gotaro Yamada Jun Nakamura Keisuke Hino Ken Nishino Junji Yodoi Hajime Nakamura Hirofumi Kawamoto Takahito Oka Noriyo Urata Daisuke Goto | 2013 | 2013 (defa)2013，，： | 2 |
| 19 | Cavernous hemangioma of the liver: pathologic correlation with dynamic CT findings 显示文摘 | Yamashita Y Ogata I Urata J | 1997 | Radiology1997，203，1： | 1 |
| 20 | Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamyl cysteine synthetase by interleukin-1 beta and tumor necrosis factor-alpha in mouse endothelial cells 显示文摘 | Urata Y Yamamoto H Goto S | 1996 | J Biol Chem1996，271，15： | 1 |
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